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    Gns glucosamine (N-acetyl)-6-sulfatase [ Mus musculus (house mouse) ]

    Gene ID: 75612, updated on 28-Oct-2024

    Summary

    Official Symbol
    Gnsprovided by MGI
    Official Full Name
    glucosamine (N-acetyl)-6-sulfataseprovided by MGI
    Primary source
    MGI:MGI:1922862
    See related
    Ensembl:ENSMUSG00000034707 AllianceGenome:MGI:1922862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G6S; 2610016K11Rik
    Summary
    Predicted to enable N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding activity; and sulfate binding activity. Predicted to be involved in keratan sulfate catabolic process. Located in lysosome. Is expressed in several structures, including eye; nervous system; skeleton; and spleen primordium. Used to study mucopolysaccharidosis III. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 66.2), kidney adult (RPKM 51.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gns in Genome Data Viewer
    Location:
    10 D2; 10 69.62 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121200995..121233159)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121365090..121397254)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 30 Neighboring gene STARR-seq mESC enhancer starr_28084 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9808 Neighboring gene STARR-positive B cell enhancer ABC_E11462 Neighboring gene predicted gene, 40785 Neighboring gene STARR-positive B cell enhancer ABC_E9809 Neighboring gene mitochondrial ribosomal protein S11 pseudogene Neighboring gene Ras association (RalGDS/AF-6) domain family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E5194 Neighboring gene predicted gene, 53638

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables N-acetylglucosamine-6-sulfatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables N-acetylglucosamine-6-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycosaminoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycosaminoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sulfate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sulfuric ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in keratan sulfate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratan sulfate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    N-acetylglucosamine-6-sulfatase
    NP_001351624.1
    NP_083640.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364695.1NP_001351624.1  N-acetylglucosamine-6-sulfatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140264
      Conserved Domains (1) summary
      cd16147
      Location:1269
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    2. NM_029364.4NP_083640.1  N-acetylglucosamine-6-sulfatase isoform 1 precursor

      See identical proteins and their annotated locations for NP_083640.1

      Status: VALIDATED

      Source sequence(s)
      AC140264
      Consensus CDS
      CCDS24210.1
      UniProtKB/Swiss-Prot
      Q3TWT0, Q8BFR4, Q8BJJ7, Q8BK91
      UniProtKB/TrEMBL
      Q3UBB0
      Related
      ENSMUSP00000043167.7, ENSMUST00000040344.7
      Conserved Domains (2) summary
      COG3119
      Location:35496
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16147
      Location:38487
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      121200995..121233159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)