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    MDL1 ATP-binding cassette permease MDL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850885, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MDL1
    Official Full Name
    ATP-binding cassette permease MDL1
    Primary source
    SGD:S000004178
    Locus tag
    YLR188W
    See related
    AllianceGenome:SGD:S000004178; FungiDB:YLR188W; VEuPathDB:YLR188W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ABC-type oligopeptide transporter activity and ATP hydrolysis activity. Involved in oligopeptide export from mitochondrion. Located in mitochondrial inner membrane. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MDL1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (528300..530387)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene 18S rRNA pseudouridine methyltransferase Neighboring gene Skg3p Neighboring gene sterol 3-beta-glucosyltransferase Neighboring gene Mmr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p. Janas E, et al. J Biol Chem, 2003 Jul 18. PMID 12746444
    2. Reversible assembly of the ATP-binding cassette transporter Mdl1 with the F1F0-ATP synthase in mitochondria. Galluhn D, et al. J Biol Chem, 2004 Sep 10. PMID 15247210
    3. Kinetics of the ATP hydrolysis cycle of the nucleotide-binding domain of Mdl1 studied by a novel site-specific labeling technique. van der Does C, et al. J Biol Chem, 2006 Mar 3. PMID 16352609
    4. Structural and functional fingerprint of the mitochondrial ATP-binding cassette transporter Mdl1 from Saccharomyces cerevisiae. Hofacker M, et al. J Biol Chem, 2007 Feb 9. PMID 17150958
    5. Switching of the homooligomeric ATP-binding cassette transport complex MDL1 from post-translational mitochondrial import to endoplasmic reticulum insertion. Gompf S, et al. FEBS J, 2007 Oct. PMID 17892490

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tom70 contributes to the presequence import pathway by recognition of the targeting signal of the Mdl1 precursor.
      Title: A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria.
    2. Modes of insertion into the mitochondrial membrane of individual segments of Mdl1 and Mdl2 differ and is dependent on domain sequence context.
      Title: Mode of membrane insertion of individual transmembrane segments in Mdl1 and Mdl2, multi-spanning mitochondrial ABC transporters.
    3. A first three-dimensional map of the mitochondrial ATP-binding cassette transporter Mdl1 complex reveals a homodimeric complex in an open conformation.
      Title: Structural and functional fingerprint of the mitochondrial ATP-binding cassette transporter Mdl1 from Saccharomyces cerevisiae.
    4. These data explain contradicting observations on the rate-limiting step of various ABC proteins such as Mdl1 and demonstrate that dimer formation is an important step in the ATP hydrolysis cycle.
      Title: Kinetics of the ATP hydrolysis cycle of the nucleotide-binding domain of Mdl1 studied by a novel site-specific labeling technique.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type oligopeptide transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ABC-type oligopeptide transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligopeptide export from mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligopeptide export from mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette permease MDL1
    NP_013289.1
    • Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      528300..530387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182075.1 → NP_013289.1  TPA: ATP-binding cassette permease MDL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013289.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYJ1, P33310
      UniProtKB/TrEMBL
      N1P1A7
      Conserved Domains (3) summary
      cd03249
      Location:432 → 676
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:116 → 676
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam00664
      Location:116 → 386
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33310.2

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