U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CCA1 tRNA adenylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856915, updated on 1-Aug-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    CCA1
    Gene description
    tRNA adenylyltransferase
    Primary source
    FungiDB:YER168C
    Locus tag
    YER168C
    See related
    SGD:S000000970; AllianceGenome:SGD:S000000970; VEuPathDB:YER168C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TNT1
    Summary
    Enables ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity and CTP:3'-cytidine-tRNA cytidylyltransferase activity. Involved in tRNA 3'-terminal CCA addition. Located in mitochondrial matrix. Used to study sideroblastic anemia. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CCA1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (521029..522669, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene aminophospholipid-translocating P4-type ATPase DNF1 Neighboring gene Bck2p Neighboring gene Rph1p Neighboring gene adenylate kinase ADK2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The ability of an arginine to tryptophan substitution in Saccharomyces cerevisiae tRNA nucleotidyltransferase to alleviate a temperature-sensitive phenotype suggests a role for motif C in active site organization. Goring ME, et al. Biochim Biophys Acta, 2013 Oct. PMID 23872483
    2. Characterization of a temperature-sensitive mutation that impairs the function of yeast tRNA nucleotidyltransferase. Shan X, et al. Yeast, 2008 Mar. PMID 18302315
    3. Mechanisms leading to and the consequences of altering the normal distribution of ATP(CTP):tRNA nucleotidyltransferase in yeast. Wolfe CL, et al. J Biol Chem, 1996 Mar 1. PMID 8617732
    4. Interplay of heterogeneous transcriptional start sites and translational selection of AUGs dictate the production of mitochondrial and cytosolic/nuclear tRNA nucleotidyltransferase from the same gene in yeast. Wolfe CL, et al. J Biol Chem, 1994 May 6. PMID 8175766
    5. Recognition of tRNA by the enzyme ATP/CTP:tRNA nucleotidyltransferase. Interference by nucleotides modified with diethyl pyrocarbonate or hydrazine. Spacciapoli P, et al. J Biol Chem, 1989 Mar 5. PMID 2645279

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A single guanine-to-adenine transition in cca1-1 generates the temperature-sensitive phenotype.
      Title: Characterization of a temperature-sensitive mutation that impairs the function of yeast tRNA nucleotidyltransferase.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CCA tRNA nucleotidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CCA tRNA nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP:tRNA cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CTP:tRNA cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA 3'-terminal CCA addition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 3'-terminal CCA addition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA 3'-terminal CCA addition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tRNA adenylyltransferase
    NP_011095.1
    • ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; human homolog TRNT1 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      521029..522669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179058.1 → NP_011095.1  TPA: tRNA adenylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM76, P21269
      UniProtKB/TrEMBL
      A0A1L4A9Y3, A6ZRC4, B3LRS8, B5VHU6, C7GS42, C8Z7J1, G2WD54
      Conserved Domains (1) summary
      COG0617
      Location:37 → 532
      PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21269.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools