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    HTRA3 HtrA serine peptidase 3 [ Homo sapiens (human) ]

    Gene ID: 94031, updated on 2-Nov-2024

    Summary

    Official Symbol
    HTRA3provided by HGNC
    Official Full Name
    HtrA serine peptidase 3provided by HGNC
    Primary source
    HGNC:HGNC:30406
    See related
    Ensembl:ENSG00000170801 MIM:608785; AllianceGenome:HGNC:30406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Prsp; Tasp
    Summary
    Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary (RPKM 19.8), gall bladder (RPKM 16.9) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See HTRA3 in Genome Data Viewer
    Location:
    4p16.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (8269754..8307098)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (8248531..8287062)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (8271481..8308825)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8175771-8176270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8177753-8178598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8189546-8190072 Neighboring gene guanine monophosphate synthase pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8191649-8192174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:8193227-8193751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21281 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8207619-8208120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8208121-8208620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8210744-8211508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8217127-8217691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8217692-8218255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8228681-8229350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8230692-8231362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8239598-8240458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8240459-8241317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8243787-8244348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8246371-8246872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8253953-8254459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8254460-8254965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8261245-8261746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15262 Neighboring gene uncharacterized LOC105374373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8293385-8293884 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:8296956-8297199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8297405-8297904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8316207-8317036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:8317037-8317864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8325636-8326136 Neighboring gene long intergenic non-protein coding RNA 2517 Neighboring gene uncharacterized LOC124900658

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase activity PubMed 
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables serine-type endopeptidase activity  
    enables serine-type peptidase activity PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in proteolysis  
    involved_in proteolysis PubMed 
    Component Evidence Code Pubs
    located_in extracellular region  

    General protein information

    Preferred Names
    serine protease HTRA3
    Names
    high-temperature requirement factor A3
    pregnancy-related serine protease
    probable serine protease HTRA3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297559.3NP_001284488.1  serine protease HTRA3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001284488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and contains an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus.
      Source sequence(s)
      AC113611, AW072765, AY280666, DN996853
      Consensus CDS
      CCDS75105.1
      UniProtKB/Swiss-Prot
      P83110
      Related
      ENSP00000371952.3, ENST00000382512.3
      Conserved Domains (3) summary
      pfam00219
      Location:2576
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:81126
      Kazal_2; Kazal-type serine protease inhibitor domain
      pfam13365
      Location:175319
      Trypsin_2; Trypsin-like peptidase domain
    2. NM_053044.5NP_444272.1  serine protease HTRA3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_444272.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC113611, BC035717
      Consensus CDS
      CCDS3400.1
      UniProtKB/Swiss-Prot
      P83110, Q7Z7A2
      Related
      ENSP00000303766.2, ENST00000307358.7
      Conserved Domains (4) summary
      cd00987
      Location:355440
      PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
      pfam00219
      Location:2576
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:81126
      Kazal_2; Kazal-type serine protease inhibitor domain
      pfam13365
      Location:175319
      Trypsin_2; Trypsin-like peptidase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      8269754..8307098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513596.4XP_011511898.1  serine protease HTRA3 isoform X1

      Conserved Domains (3) summary
      pfam00219
      Location:2576
      IGFBP; Insulin-like growth factor binding protein
      pfam07648
      Location:81126
      Kazal_2; Kazal-type serine protease inhibitor domain
      pfam13365
      Location:175319
      Trypsin_2; Trypsin-like peptidase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      8248531..8287062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351282.1XP_054207257.1  serine protease HTRA3 isoform X1

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