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    AP1AR adaptor related protein complex 1 associated regulatory protein [ Homo sapiens (human) ]

    Gene ID: 55435, updated on 3-Nov-2024

    Summary

    Official Symbol
    AP1ARprovided by HGNC
    Official Full Name
    adaptor related protein complex 1 associated regulatory proteinprovided by HGNC
    Primary source
    HGNC:HGNC:28808
    See related
    Ensembl:ENSG00000138660 MIM:610851; AllianceGenome:HGNC:28808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2C18; GBAR; C4orf16; PRO0971; gamma-BAR
    Summary
    Enables AP-1 adaptor complex binding activity and kinesin binding activity. Involved in negative regulation of receptor recycling and vesicle targeting, trans-Golgi to endosome. Acts upstream of or within negative regulation of substrate adhesion-dependent cell spreading. Located in Golgi apparatus and transport vesicle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in small intestine (RPKM 6.6), kidney (RPKM 6.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See AP1AR in Genome Data Viewer
    Location:
    4q25
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (112231787..112273110)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (115540139..115581470)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113152943..113194266)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21820 Neighboring gene family with sequence similarity 241 member A Neighboring gene ribosomal protein L36a pseudogene 19 Neighboring gene Sharpr-MPRA regulatory region 3285 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113152716-113153663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15636 Neighboring gene AP1AR divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21826 Neighboring gene Sharpr-MPRA regulatory region 9995 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:113230537-113231036 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:113230035-113230536 Neighboring gene TRAF interacting protein with forkhead associated domain Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21827 Neighboring gene alpha kinase 1 Neighboring gene regulator of telomere elongation helicase 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding  
    enables AP-1 adaptor complex binding PubMed 
    enables kinesin binding  
    enables kinesin binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cytosol  
    located_in early endosome  
    is_active_in endosome  
    located_in late endosome  
    located_in transport vesicle  

    General protein information

    Preferred Names
    AP-1 complex-associated regulatory protein
    Names
    adapter-related protein complex 1-associated regulatory protein
    gadkin
    gamma-1-adaptin brefeldin A resistance protein
    gamma-A1-adaptin and kinesin interactor
    gamma1-adaptin brefeldin A resistance protein, gamma-BAR

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128426.3NP_001121898.1  AP-1 complex-associated regulatory protein isoform 2

      See identical proteins and their annotated locations for NP_001121898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the mid-coding region compared to variant 1. The resulting shorter isoform (2) has the same N- and C- termini but lacks an internal protein segment compared to isoform 1.
      Source sequence(s)
      AC109347, AF116612, AI246762, AI798931, BC009485, BU740563, BX498932, CN291547, DA463845
      Consensus CDS
      CCDS47125.1
      Related
      ENSP00000309023.6, ENST00000309703.10
      Conserved Domains (1) summary
      pfam15745
      Location:26269
      AP1AR; AP-1 complex-associated regulatory protein
    2. NM_018569.6NP_061039.3  AP-1 complex-associated regulatory protein isoform 1

      See identical proteins and their annotated locations for NP_061039.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC109347, AF116612, AI246762, AI798931, BU740563, BX498932, BX647702, CN291547
      Consensus CDS
      CCDS3696.1
      UniProtKB/Swiss-Prot
      B2RCV7, Q63HQ0, Q96GG6, Q9H0V0, Q9P1L4
      Related
      ENSP00000274000.5, ENST00000274000.10
      Conserved Domains (1) summary
      pfam15745
      Location:26302
      AP1AR; AP-1 complex-associated regulatory protein

    RNA

    1. NR_136622.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate acceptor splice site at an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC109347, AF116612, AI246762, AI798931, BM823928, BU740563, BX498932, CN291547, DA463845

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      112231787..112273110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008380.2XP_016863869.1  AP-1 complex-associated regulatory protein isoform X3

      Conserved Domains (1) summary
      pfam15745
      Location:1142
      AP1AR; AP-1 complex-associated regulatory protein
    2. XM_047415928.1XP_047271884.1  AP-1 complex-associated regulatory protein isoform X2

    3. XM_047415927.1XP_047271883.1  AP-1 complex-associated regulatory protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      115540139..115581470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350446.1XP_054206421.1  AP-1 complex-associated regulatory protein isoform X3

    2. XM_054350445.1XP_054206420.1  AP-1 complex-associated regulatory protein isoform X2

    3. XM_054350444.1XP_054206419.1  AP-1 complex-associated regulatory protein isoform X1

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