CDCA7L cell division cycle associated 7 like [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDCA7Lprovided by HGNC
Official Full Name: cell division cycle associated 7 likeprovided by HGNC
Primary source: HGNC:HGNC:30777
See related: Ensembl:ENSG00000164649 MIM:609685; AllianceGenome:HGNC:30777
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: R1; JPO2; RAM2
Summary: Acts upstream of or within positive regulation of cell population proliferation. Located in cytosol; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in thyroid (RPKM 17.0), bone marrow (RPKM 16.5) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7p15.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (21900899..21945899, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (22037210..22082187, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (21940517..21985517, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results identified and confirmed to have downregulated gene expression of SFRP5 in sporadic nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and CDCA7L and RBM47 in MEN1-related NFPanNETs.
Title: Distinct genome-wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors.
CDCA7L is highly expressed in human glioma tissues and that a high CDCA7L expression predicts a poor prognosis of glioma patients. CDCA7L promotes glioma U87 cell growth through CCND1.
Title: CDCA7L promotes glioma proliferation by targeting CCND1 and predicts an unfavorable prognosis.
Study demonstrated the elevated expression of R1 in human prostate cancer tissue and cell lines at both protein and mRNA levels. Further results provide evidence that R1 is a novel regulator of prostate tumor growth by stabilizing c-Myc protein through transcriptional suppression of HUWE1.
Title: R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.
CDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients
Title: Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma.
Suppression of CDCA7L limits multiple myeloma proliferation through apoptosis.
Title: Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression.
We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma
Title: JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.
common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN
Title: Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 and MYC.
Title: The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells.
Data indicate that JPO2 and LEDGF/p75 interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75.
Title: Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.
CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC progression.
Title: CDCA7L promotes hepatocellular carcinoma progression by regulating the cell cycle.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat downregulates the expression of cell division cycle associated 7-like (CDCA7L; JPO2) in human primary T cells	PubMed
	tat	HIV-1 Tat-mediated stimulation of the viral LTR is increased in the presence of JPO2	PubMed
integrase	gag-pol	Both HIV-1 IN and JPO2 proteins are present as oligomers and co-localize in the nucleus of HeLa cells	PubMed
	gag-pol	The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partner, CDCA7L (JOP2)	PubMed
	gag-pol	The HIV-1 IN interaction site on the PSIP1 (LEDGF/p75) intergrase binding domain (IBD) overlaps with that of JPO2	PubMed
	gag-pol	HIV-1 IN and JPO2 bind mutually exclusively to LEDGF/p75. Two LEDGF/p75 mutants (I365A and D366N) abrogate interaction between LEDGF/p75 and IN but interact with JPO2 to the same extent as wild-type LEDGF/p75	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH65966 (e-PCR)
- UniSTS:38751

RH75427 (e-PCR)
- UniSTS:91621

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: cell division cycle-associated 7-like protein

Names: transcription factor RAM2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127370.3 → NP_001120842.1 cell division cycle-associated 7-like protein isoform 2

See identical proteins and their annotated locations for NP_001120842.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR which results in the use of a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AA922229, AK022955, AK095965, AL576822, BC009352, BU753973, DA041070

Consensus CDS

CCDS47559.1

UniProtKB/TrEMBL

A8K8X5

Related

ENSP00000348523.5, ENST00000356195.9

Conserved Domains (1) summary

pfam10497
Location:311 → 409

zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
NM_001127371.3 → NP_001120843.1 cell division cycle-associated 7-like protein isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame coding exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.

Source sequence(s)

AA922229, AK022955, AK300781, AL576822, BU753973, BX422040, DC331792

Consensus CDS

CCDS47558.1

UniProtKB/TrEMBL

A8K8X5

Related

ENSP00000363045.4, ENST00000373934.4

Conserved Domains (1) summary

pfam10497
Location:299 → 397

zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
NM_018719.5 → NP_061189.2 cell division cycle-associated 7-like protein isoform 1

See identical proteins and their annotated locations for NP_061189.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the predominant and longest protein (isoform 1).

Source sequence(s)

AA922229, AK022955, AK292490, AL576822, BC009352, BU753973

Consensus CDS

CCDS5374.1

UniProtKB/Swiss-Prot

A4D141, A6NF50, B3KTR5, B4DUT3, C9K0Y1, Q6PIL4, Q86YT0, Q8IXN5, Q96C70, Q96GN5, Q9H9A2, Q9NPV2

UniProtKB/TrEMBL

A8K8X5

Related

ENSP00000383986.3, ENST00000406877.8

Conserved Domains (1) summary

pfam10497
Location:345 → 443

zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1