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    ZNF573 zinc finger protein 573 [ Homo sapiens (human) ]

    Gene ID: 126231, updated on 28-Oct-2024

    Summary

    Official Symbol
    ZNF573provided by HGNC
    Official Full Name
    zinc finger protein 573provided by HGNC
    Primary source
    HGNC:HGNC:26420
    See related
    Ensembl:ENSG00000189144 AllianceGenome:HGNC:26420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.0), spleen (RPKM 0.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF573 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37738302..37779586, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40540059..40581107, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38229203..38270226, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38186077-38186752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38187429-38188103 Neighboring gene selenoprotein K pseudogene 1 Neighboring gene zinc finger protein 607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10558 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:38269714-38270377 and GRCh37_chr19:38270378-38271040 Neighboring gene uncharacterized LOC105372394 Neighboring gene IST1 homolog Neighboring gene zinc finger protein 607 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ30921

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172689.2NP_001166160.1  zinc finger protein 573 isoform 2

      See identical proteins and their annotated locations for NP_001166160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three alternate exons, includes an additional exon, and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AC016582, AK055483, AK074539, BC042170, DA778380
      UniProtKB/Swiss-Prot
      Q86YE8
      Conserved Domains (3) summary
      COG5048
      Location:156540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:496516
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:172197
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001172690.2NP_001166161.1  zinc finger protein 573 isoform 3

      See identical proteins and their annotated locations for NP_001166161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons and uses an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK055483, BC042170, BP274132
      Consensus CDS
      CCDS59381.1
      UniProtKB/Swiss-Prot
      B7WPE1, K7EJ45, Q6P1P1, Q7Z7Q3, Q86YE8, Q8N2Q1, Q96BM3, Q96NH0
      Related
      ENSP00000440464.2, ENST00000536220.7
      Conserved Domains (5) summary
      smart00349
      Location:2889
      KRAB; krueppel associated box
      COG5048
      Location:244628
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:584604
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2867
      KRAB; KRAB box
      pfam13465
      Location:260285
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001172691.2NP_001166162.1  zinc finger protein 573 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate exons, uses an alternate splice site, and uses an upstream start codon, compared to variant 1. The resulting isoform (4) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK055483, BC042170, BG572864, DA778380
      UniProtKB/Swiss-Prot
      Q86YE8
      Conserved Domains (5) summary
      smart00349
      Location:2687
      KRAB; krueppel associated box
      COG5048
      Location:242626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:582602
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2665
      KRAB; KRAB box
      pfam13465
      Location:258283
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001172692.2NP_001166163.1  zinc finger protein 573 isoform 2

      See identical proteins and their annotated locations for NP_001166163.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks four alternate exons and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AK055483, BC042170, DA778380, DB121870
      UniProtKB/Swiss-Prot
      Q86YE8
      Conserved Domains (3) summary
      COG5048
      Location:156540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:496516
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:172197
      zf-H2C2_2; Zinc-finger double domain
    5. NM_152360.4NP_689573.3  zinc finger protein 573 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK055483, BC064962, DA778380
      Consensus CDS
      CCDS12508.1
      UniProtKB/Swiss-Prot
      Q86YE8
      Related
      ENSP00000340171.4, ENST00000339503.7
      Conserved Domains (4) summary
      COG5048
      Location:186570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:526546
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:202227
      zf-H2C2_2; Zinc-finger double domain
      pfam13900
      Location:634
      GVQW; Putative domain of unknown function

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37738302..37779586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      40540059..40581107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)