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    MISP mitotic spindle positioning [ Homo sapiens (human) ]

    Gene ID: 126353, updated on 28-Oct-2024

    Summary

    Official Symbol
    MISPprovided by HGNC
    Official Full Name
    mitotic spindle positioningprovided by HGNC
    Primary source
    HGNC:HGNC:27000
    See related
    Ensembl:ENSG00000099812 MIM:615289; AllianceGenome:HGNC:27000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MISP1; C19orf21
    Summary
    The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]
    Expression
    Biased expression in small intestine (RPKM 92.0), duodenum (RPKM 77.1) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MISP in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (748438..764318)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (702466..718374)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (751112..764318)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene serine protease 57 Neighboring gene ribosomal protein S2 pseudogene 52 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:704097-705067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:707932-708492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:718052-718584 Neighboring gene paralemmin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:778723-779437 Neighboring gene uncharacterized LOC101928450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:782349-782922 Neighboring gene long intergenic non-protein coding RNA 1836

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates MISP (C19orf21) in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686H18209

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in organelle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin filament IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with cortical actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with focal adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in focal adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with mitotic spindle astral microtubule end IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in spindle pole centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    mitotic interactor and substrate of PLK1
    Names
    caprice
    mitotic interactor and substrate of Plk1
    mitotic spindle positioning protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173481.4NP_775752.1  mitotic interactor and substrate of PLK1

      See identical proteins and their annotated locations for NP_775752.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AC004030, BC052236, HY163020
      Consensus CDS
      CCDS12042.1
      UniProtKB/Swiss-Prot
      Q8IVT2
      Related
      ENSP00000215582.4, ENST00000215582.8
      Conserved Domains (1) summary
      pfam15304
      Location:325674
      AKAP2_C; A-kinase anchor protein 2 C-terminus

    RNA

    1. NR_135168.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC004030, BC052236, HY163020, HY173833

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      748438..764318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527685.3XP_011525987.1  mitotic interactor and substrate of PLK1 isoform X1

      See identical proteins and their annotated locations for XP_011525987.1

      UniProtKB/Swiss-Prot
      Q8IVT2
      Conserved Domains (1) summary
      pfam15304
      Location:325674
      AKAP2_C; A-kinase anchor protein 2 C-terminus
    2. XM_011527686.3XP_011525988.1  mitotic interactor and substrate of PLK1 isoform X1

      See identical proteins and their annotated locations for XP_011525988.1

      UniProtKB/Swiss-Prot
      Q8IVT2
      Conserved Domains (1) summary
      pfam15304
      Location:325674
      AKAP2_C; A-kinase anchor protein 2 C-terminus

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      702466..718374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319805.1XP_054175780.1  mitotic interactor and substrate of PLK1 isoform X1

      UniProtKB/Swiss-Prot
      Q8IVT2
    2. XM_054319806.1XP_054175781.1  mitotic interactor and substrate of PLK1 isoform X1

      UniProtKB/Swiss-Prot
      Q8IVT2