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    PPFIBP1 PPFIA binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 8496, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PPFIBP1provided by HGNC
    Official Full Name
    PPFIA binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:9249
    See related
    Ensembl:ENSG00000110841 MIM:603141; AllianceGenome:HGNC:9249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L2; SGT2; hSGT2; hSgt2p; NEDSMBA
    Summary
    The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 22.3), heart (RPKM 16.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPFIBP1 in Genome Data Viewer
    Location:
    12p11.23-p11.22
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (27524206..27695564)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (27395877..27567299)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27677139..27848497)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix ARNT like 2 Neighboring gene BMAL2 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:27589181-27589746 Neighboring gene single-pass membrane protein with coiled-coil domains 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:27627037-27628236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:27631436-27631936 Neighboring gene arginyl-tRNA synthetase 1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:27675956-27676557 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:27677161-27677761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6146 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:27701742-27702941 Neighboring gene Sharpr-MPRA regulatory region 6326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4312 Neighboring gene chromosome 12 open reading frame 71B, pseudogene Neighboring gene MRPS35 divergent transcript Neighboring gene high mobility group box 1 pseudogene 49 Neighboring gene RAB15 effector protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel homozygous truncating variant in PPFIBP1 further delineates PPFIBP1-associated neurodevelopmental disorder. Waqas A, et al. Int J Dev Neurosci, 2023 Apr. PMID 36527195
    2. PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway. Dong C, et al. Cell Death Dis, 2021 Sep 3. PMID 34480020, Free PMC Article
    3. Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Norrmén C, et al. Blood, 2010 Jan 28. PMID 19965622, Free PMC Article
    4. Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification. Takeuchi K, et al. Clin Cancer Res, 2011 May 15. PMID 21430068
    5. Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1). Kriajevska M, et al. J Biol Chem, 2002 Feb 15. PMID 11836260

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel homozygous truncating variant in PPFIBP1 further delineates PPFIBP1-associated neurodevelopmental disorder.
      Title: A novel homozygous truncating variant in PPFIBP1 further delineates PPFIBP1-associated neurodevelopmental disorder.
    2. PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway.
      Title: PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway.
    3. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma
      Title: Association of liprin β-1 with kank proteins in melanoma.
    4. Analysis of the role of liprin-beta1 and liprin-beta2 has shown that while liprin-beta1 contributes positively to tumour cell motility in vitro; liprin-beta2 has a negative effect on both cell motility and invasion.
      Title: Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells.
    5. Liprins can mediate assembly of target proteins into large protein complexes capable of regulating numerous cellular activities.
      Title: Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.
    6. Novel ALK fusions are being identified in various tumors in addition to inflammatory myofibroblastic tumor.
      Title: Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. liprin beta1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo
      Title: Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.
    9. new molecular target of the S100A4 protein, liprin beta1
      Title: Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with seizures, microcephaly, and brain abnormalities
    MedGen: C5774209 OMIM: 620024 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein, binding protein 1, beta 1 (PPFIBP1) is important for HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    liprin-beta-1
    Names
    PTPRF interacting protein, binding protein 1 (liprin beta 1)
    PTPRF-interacting protein-binding protein 1
    liprin related protein
    protein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198915.2 → NP_001185844.1  liprin-beta-1 isoform 3

      See identical proteins and their annotated locations for NP_001185844.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2.
      Source sequence(s)
      AC009509, AC068794, AC087257
      Consensus CDS
      CCDS55814.1
      UniProtKB/TrEMBL
      F5GZP6
      Related
      ENSP00000445425.1, ENST00000537927.5
      Conserved Domains (5) summary
      cd09563
      Location:491 → 554
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:565 → 627
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:650 → 721
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      PTZ00108
      Location:6 → 360
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:2 → 178
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001198916.2 → NP_001185845.2  liprin-beta-1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 2.
      Source sequence(s)
      AC009509, AC068794, AC087257
      Consensus CDS
      CCDS55813.1
      Related
      ENSP00000443442.1, ENST00000542629.5
      Conserved Domains (4) summary
      cd09563
      Location:613 → 676
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:687 → 749
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:772 → 843
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:103 → 311
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_003622.4 → NP_003613.4  liprin-beta-1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has multiple differences in the coding sequence compared to variant 2. The resulting isoform (1) has the same N- and C-termini but is 6 aa shorter compared to isoform 2.
      Source sequence(s)
      AC009509, AC068794, AC087257
      Consensus CDS
      CCDS8713.1
      Related
      ENSP00000228425.6, ENST00000228425.11
      Conserved Domains (4) summary
      cd09563
      Location:638 → 701
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:712 → 774
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:797 → 868
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:103 → 322
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_177444.3 → NP_803193.3  liprin-beta-1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AC009509, AC068794, AC087257
      Consensus CDS
      CCDS55812.1
      UniProtKB/Swiss-Prot
      O75336, Q86W92, Q86X70, Q9NY03, Q9ULJ0
      Related
      ENSP00000314724.8, ENST00000318304.12
      Conserved Domains (4) summary
      cd09563
      Location:644 → 707
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:718 → 780
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:803 → 874
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      27524206..27695564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020056.3 → XP_016875545.1  liprin-beta-1 isoform X1

      Conserved Domains (4) summary
      cd09563
      Location:669 → 732
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:743 → 805
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:828 → 899
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 352
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_047429753.1 → XP_047285709.1  liprin-beta-1 isoform X14

    3. XM_047429758.1 → XP_047285714.1  liprin-beta-1 isoform X22

    4. XM_047429754.1 → XP_047285710.1  liprin-beta-1 isoform X19

    5. XM_047429760.1 → XP_047285716.1  liprin-beta-1 isoform X25

    6. XM_047429764.1 → XP_047285720.1  liprin-beta-1 isoform X29

    7. XM_047429755.1 → XP_047285711.1  liprin-beta-1 isoform X21

    8. XM_047429761.1 → XP_047285717.1  liprin-beta-1 isoform X26

    9. XM_047429765.1 → XP_047285721.1  liprin-beta-1 isoform X30

    10. XM_024449232.2 → XP_024305000.1  liprin-beta-1 isoform X1

      Conserved Domains (4) summary
      cd09563
      Location:669 → 732
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:743 → 805
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:828 → 899
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 352
      SMC_N; RecF/RecN/SMC N terminal domain

    11. XM_017020059.3 → XP_016875548.1  liprin-beta-1 isoform X5

      Conserved Domains (7) summary
      cd09563
      Location:658 → 721
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:732 → 794
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:817 → 888
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:658 → 722
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam03528
      Location:103 → 506
      Rabaptin; Rabaptin
      cl19219
      Location:203 → 308
      DUF342; Protein of unknown function (DUF342)

    12. XM_024449234.2 → XP_024305002.1  liprin-beta-1 isoform X3

      Conserved Domains (4) summary
      cd09563
      Location:659 → 722
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:733 → 795
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:818 → 889
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 352
      SMC_N; RecF/RecN/SMC N terminal domain

    13. XM_024449237.2 → XP_024305005.1  liprin-beta-1 isoform X9

      Conserved Domains (4) summary
      cd09563
      Location:648 → 711
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:722 → 784
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:807 → 878
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 352
      SMC_N; RecF/RecN/SMC N terminal domain

    14. XM_024449233.2 → XP_024305001.1  liprin-beta-1 isoform X2

      Conserved Domains (4) summary
      cd09563
      Location:666 → 729
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:740 → 802
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:825 → 896
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:100 → 352
      SMC_N; RecF/RecN/SMC N terminal domain

    15. XM_017020061.3 → XP_016875550.1  liprin-beta-1 isoform X8

    16. XM_017020058.3 → XP_016875547.1  liprin-beta-1 isoform X6

    17. XM_047429752.1 → XP_047285708.1  liprin-beta-1 isoform X13

    18. XM_024449235.2 → XP_024305003.1  liprin-beta-1 isoform X4

      Conserved Domains (4) summary
      cd09563
      Location:658 → 721
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:732 → 794
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:817 → 888
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 341
      SMC_N; RecF/RecN/SMC N terminal domain

    19. XM_017020062.3 → XP_016875551.1  liprin-beta-1 isoform X11

      Conserved Domains (6) summary
      cd09563
      Location:647 → 710
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:721 → 783
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:806 → 877
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:647 → 711
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      cl19219
      Location:203 → 281
      DUF342; Protein of unknown function (DUF342)

    20. XM_047429750.1 → XP_047285706.1  liprin-beta-1 isoform X10

    21. XM_017020063.3 → XP_016875552.1  liprin-beta-1 isoform X15

    22. XM_024449236.2 → XP_024305004.1  liprin-beta-1 isoform X7

      Conserved Domains (4) summary
      cd09563
      Location:655 → 718
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:729 → 791
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:814 → 885
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 341
      SMC_N; RecF/RecN/SMC N terminal domain

    23. XM_047429751.1 → XP_047285707.1  liprin-beta-1 isoform X12

    24. XM_017020065.3 → XP_016875554.1  liprin-beta-1 isoform X17

    25. XM_017020068.3 → XP_016875557.1  liprin-beta-1 isoform X20

    26. XM_017020066.3 → XP_016875555.1  liprin-beta-1 isoform X18

    27. XM_017020071.3 → XP_016875560.1  liprin-beta-1 isoform X28

    28. XM_017020064.3 → XP_016875553.1  liprin-beta-1 isoform X16

      Conserved Domains (8) summary
      cd09563
      Location:635 → 698
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:709 → 771
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:794 → 865
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:635 → 699
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam14662
      Location:106 → 313
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl23720
      Location:134 → 270
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23750
      Location:218 → 330
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    29. XM_017020070.3 → XP_016875559.1  liprin-beta-1 isoform X22

      Conserved Domains (8) summary
      cd09563
      Location:624 → 687
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:698 → 760
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:783 → 854
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:624 → 688
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam14662
      Location:106 → 313
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl23720
      Location:134 → 270
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23750
      Location:218 → 330
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    30. XM_047429756.1 → XP_047285712.1  liprin-beta-1 isoform X23

    31. XM_017020073.3 → XP_016875562.1  liprin-beta-1 isoform X27

    32. XM_017020067.3 → XP_016875556.1  liprin-beta-1 isoform X19

      Conserved Domains (6) summary
      cd09563
      Location:627 → 690
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:701 → 763
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:786 → 857
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:627 → 691
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      cl23720
      Location:134 → 270
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    33. XM_017020072.3 → XP_016875561.1  liprin-beta-1 isoform X25

    34. XM_047429757.1 → XP_047285713.1  liprin-beta-1 isoform X24

    35. XM_047429762.1 → XP_047285718.1  liprin-beta-1 isoform X29

    36. XM_017020069.3 → XP_016875558.1  liprin-beta-1 isoform X21

      Conserved Domains (6) summary
      cd09563
      Location:624 → 687
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:698 → 760
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:783 → 854
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:624 → 688
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      cl23720
      Location:134 → 270
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    37. XM_047429759.1 → XP_047285715.1  liprin-beta-1 isoform X26

    38. XM_047429763.1 → XP_047285719.1  liprin-beta-1 isoform X30

    39. XM_006719159.5 → XP_006719222.1  liprin-beta-1 isoform X31

      UniProtKB/TrEMBL
      F5GZP6
      Conserved Domains (5) summary
      cd09563
      Location:516 → 579
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:590 → 652
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:675 → 746
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:516 → 580
      SAM; Sterile alpha motif
      cl19219
      Location:50 → 155
      DUF342; Protein of unknown function (DUF342)

    40. XM_024449238.2 → XP_024305006.1  liprin-beta-1 isoform X33

      Conserved Domains (1) summary
      cl25732
      Location:100 → 352
      SMC_N; RecF/RecN/SMC N terminal domain

    41. XM_017020078.2 → XP_016875567.1  liprin-beta-1 isoform X34

    42. XM_047429767.1 → XP_047285723.1  liprin-beta-1 isoform X36

    43. XM_047429768.1 → XP_047285724.1  liprin-beta-1 isoform X37

    44. XM_047429766.1 → XP_047285722.1  liprin-beta-1 isoform X35

    45. XM_017020057.3 → XP_016875546.1  liprin-beta-1 isoform X1

      Conserved Domains (4) summary
      cd09563
      Location:669 → 732
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:743 → 805
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:828 → 899
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 352
      SMC_N; RecF/RecN/SMC N terminal domain

    46. XM_017020076.3 → XP_016875565.1  liprin-beta-1 isoform X32

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      27395877..27567299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373600.1 → XP_054229575.1  liprin-beta-1 isoform X1

    2. XM_054373614.1 → XP_054229589.1  liprin-beta-1 isoform X14

    3. XM_054373627.1 → XP_054229602.1  liprin-beta-1 isoform X22

    4. XM_054373621.1 → XP_054229596.1  liprin-beta-1 isoform X19

    5. XM_054373632.1 → XP_054229607.1  liprin-beta-1 isoform X25

    6. XM_054373636.1 → XP_054229611.1  liprin-beta-1 isoform X29

    7. XM_054373624.1 → XP_054229599.1  liprin-beta-1 isoform X21

    8. XM_054373633.1 → XP_054229608.1  liprin-beta-1 isoform X26

    9. XM_054373637.1 → XP_054229612.1  liprin-beta-1 isoform X30

    10. XM_054373599.1 → XP_054229574.1  liprin-beta-1 isoform X1

    11. XM_054373605.1 → XP_054229580.1  liprin-beta-1 isoform X5

    12. XM_054373603.1 → XP_054229578.1  liprin-beta-1 isoform X3

    13. XM_054373609.1 → XP_054229584.1  liprin-beta-1 isoform X9

    14. XM_054373602.1 → XP_054229577.1  liprin-beta-1 isoform X2

    15. XM_054373608.1 → XP_054229583.1  liprin-beta-1 isoform X8

    16. XM_054373606.1 → XP_054229581.1  liprin-beta-1 isoform X6

    17. XM_054373613.1 → XP_054229588.1  liprin-beta-1 isoform X13

    18. XM_054373604.1 → XP_054229579.1  liprin-beta-1 isoform X4

    19. XM_054373611.1 → XP_054229586.1  liprin-beta-1 isoform X11

    20. XM_054373610.1 → XP_054229585.1  liprin-beta-1 isoform X10

    21. XM_054373615.1 → XP_054229590.1  liprin-beta-1 isoform X15

    22. XM_054373607.1 → XP_054229582.1  liprin-beta-1 isoform X7

    23. XM_054373612.1 → XP_054229587.1  liprin-beta-1 isoform X12

    24. XM_054373617.1 → XP_054229592.1  liprin-beta-1 isoform X17

    25. XM_054373620.1 → XP_054229595.1  liprin-beta-1 isoform X20

    26. XM_054373618.1 → XP_054229593.1  liprin-beta-1 isoform X18

    27. XM_054373631.1 → XP_054229606.1  liprin-beta-1 isoform X28

    28. XM_054373616.1 → XP_054229591.1  liprin-beta-1 isoform X16

    29. XM_054373623.1 → XP_054229598.1  liprin-beta-1 isoform X22

    30. XM_054373625.1 → XP_054229600.1  liprin-beta-1 isoform X23

    31. XM_054373630.1 → XP_054229605.1  liprin-beta-1 isoform X27

    32. XM_054373619.1 → XP_054229594.1  liprin-beta-1 isoform X19

    33. XM_054373628.1 → XP_054229603.1  liprin-beta-1 isoform X25

    34. XM_054373626.1 → XP_054229601.1  liprin-beta-1 isoform X24

    35. XM_054373634.1 → XP_054229609.1  liprin-beta-1 isoform X29

    36. XM_054373622.1 → XP_054229597.1  liprin-beta-1 isoform X21

    37. XM_054373629.1 → XP_054229604.1  liprin-beta-1 isoform X26

    38. XM_054373635.1 → XP_054229610.1  liprin-beta-1 isoform X30

    39. XM_054373638.1 → XP_054229613.1  liprin-beta-1 isoform X31

    40. XM_054373640.1 → XP_054229615.1  liprin-beta-1 isoform X33

    41. XM_054373641.1 → XP_054229616.1  liprin-beta-1 isoform X34

    42. XM_054373643.1 → XP_054229618.1  liprin-beta-1 isoform X36

    43. XM_054373644.1 → XP_054229619.1  liprin-beta-1 isoform X37

    44. XM_054373642.1 → XP_054229617.1  liprin-beta-1 isoform X35

    45. XM_054373601.1 → XP_054229576.1  liprin-beta-1 isoform X1

    46. XM_054373639.1 → XP_054229614.1  liprin-beta-1 isoform X32

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86W92.2 GenPept UniProtKB/Swiss-Prot:Q86W92

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