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    RPS7 ribosomal protein S7 [ Homo sapiens (human) ]

    Gene ID: 6201, updated on 5-May-2024

    Summary

    Official Symbol
    RPS7provided by HGNC
    Official Full Name
    ribosomal protein S7provided by HGNC
    Primary source
    HGNC:HGNC:10440
    See related
    Ensembl:ENSG00000171863 MIM:603658; AllianceGenome:HGNC:10440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S7; eS7; DBA8
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 822.9), bone marrow (RPKM 559.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPS7 in Genome Data Viewer
    Location:
    2p25.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (3575260..3580920)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (3597803..3603463)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (3622850..3628510)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3607689-3608586 Neighboring gene RNASEH1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15233 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:3615875-3616480 Neighboring gene uncharacterized LOC124907726 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:3616481-3617087 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:3617088-3617693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3622403-3622978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:3622979-3623555 Neighboring gene collectin subfamily member 11 Neighboring gene NANOG hESC enhancer GRCh37_chr2:3662665-3663169 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:3669609-3669758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15235 Neighboring gene TMSB4X pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3675117-3675828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3699531-3700279 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:3707659-3707935 Neighboring gene allantoicase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15238 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 48

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human ribosomal protein S7 (RPS7) at amino acid residues 27-28 and 30-31 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural crest cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic small ribosomal subunit HDA PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribosome HDA PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    small ribosomal subunit protein eS7
    Names
    40S ribosomal protein S7
    NP_001002.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011744.1 RefSeqGene

      Range
      4998..10658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1148

    mRNA and Protein(s)

    1. NM_001011.4NP_001002.1  small ribosomal subunit protein eS7

      See identical proteins and their annotated locations for NP_001002.1

      Status: REVIEWED

      Source sequence(s)
      BC002866, BF312642, BU963807
      Consensus CDS
      CCDS1648.1
      UniProtKB/Swiss-Prot
      P23821, P24818, P62081, Q57Z92, Q6IPH1
      UniProtKB/TrEMBL
      A0A2R8Y623
      Related
      ENSP00000496757.1, ENST00000645674.2
      Conserved Domains (1) summary
      pfam01251
      Location:7191
      Ribosomal_S7e; Ribosomal protein S7e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      3575260..3580920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      3597803..3603463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)