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    FTO FTO alpha-ketoglutarate dependent dioxygenase [ Homo sapiens (human) ]

    Gene ID: 79068, updated on 4-Mar-2024

    Summary

    Official Symbol
    FTOprovided by HGNC
    Official Full Name
    FTO alpha-ketoglutarate dependent dioxygenaseprovided by HGNC
    Primary source
    HGNC:HGNC:24678
    See related
    Ensembl:ENSG00000140718 MIM:610966; AllianceGenome:HGNC:24678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GDFD; IFEX9; ALKBH9; BMIQ14
    Summary
    This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
    Expression
    Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FTO in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (53703963..54121941)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (59501796..59919950)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (53737875..54155853)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371269 Neighboring gene NANOG hESC enhancer GRCh37_chr16:53580827-53581328 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:53594743-53595365 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:53595366-53595988 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:53610651-53610873 Neighboring gene NANOG hESC enhancer GRCh37_chr16:53659615-53660133 Neighboring gene RPGRIP1 like Neighboring gene VISTA enhancer hs59 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:53737766-53738266 Neighboring gene uncharacterized LOC124903691 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:53861530-53862207 Neighboring gene Sharpr-MPRA regulatory region 10092 Neighboring gene VISTA enhancer hs155 Neighboring gene Sharpr-MPRA regulatory region 7594 Neighboring gene VISTA enhancer hs157 Neighboring gene VISTA enhancer hs156 Neighboring gene Sharpr-MPRA regulatory region 2551 Neighboring gene uncharacterized LOC105371271 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:54082723-54083657 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:54083658-54084591 Neighboring gene FTO intronic transcript 1 Neighboring gene VISTA enhancer hs52 Neighboring gene Sharpr-MPRA regulatory region 5065 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:54228087-54228979 Neighboring gene Sharpr-MPRA regulatory region 10961 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:54318795-54319714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:54319715-54320634 Neighboring gene long intergenic non-protein coding RNA 2169 Neighboring gene iroquois homeobox 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Body mass index quantitative trait locus 14
    MedGen: C2675914 OMIM: 612460 GeneReviews: Not available
    Compare labs
    Lethal polymalformative syndrome, Boissel type
    MedGen: C2752001 OMIM: 612938 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
    EBI GWAS Catalog
    A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
    EBI GWAS Catalog
    A genome-wide association study on obesity and obesity-related traits.
    EBI GWAS Catalog
    A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
    EBI GWAS Catalog
    A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
    EBI GWAS Catalog
    A variant in FTO shows association with melanoma risk not due to BMI.
    EBI GWAS Catalog
    Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
    EBI GWAS Catalog
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Common body mass index-associated variants confer risk of extreme obesity.
    EBI GWAS Catalog
    Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
    EBI GWAS Catalog
    Common variants near MC4R are associated with fat mass, weight and risk of obesity.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.
    EBI GWAS Catalog
    FTO genotype is associated with phenotypic variability of body mass index.
    EBI GWAS Catalog
    Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
    EBI GWAS Catalog
    Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.
    EBI GWAS Catalog
    Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
    EBI GWAS Catalog
    Genome-wide association analysis of body mass in chronic obstructive pulmonary disease.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.
    EBI GWAS Catalog
    Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
    EBI GWAS Catalog
    Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
    EBI GWAS Catalog
    Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
    EBI GWAS Catalog
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    EBI GWAS Catalog
    Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
    EBI GWAS Catalog
    Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.
    EBI GWAS Catalog
    Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
    EBI GWAS Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    EBI GWAS Catalog
    Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
    EBI GWAS Catalog
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    EBI GWAS Catalog
    NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
    EBI GWAS Catalog
    Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
    EBI GWAS Catalog
    Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
    EBI GWAS Catalog
    Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
    EBI GWAS Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    EBI GWAS Catalog
    Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC5149, KIAA1752

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables broad specificity oxidative DNA demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables broad specificity oxidative DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA N6-methyladenosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA N6-methyladenosine dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA N6-methyladenosine dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables oxidative RNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tRNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA dealkylation involved in DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxidative demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxidative single-stranded DNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxidative single-stranded DNA demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxidative single-stranded RNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxidative single-stranded RNA demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxidative single-stranded RNA demethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of white fat cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    alpha-ketoglutarate-dependent dioxygenase FTO
    Names
    AlkB homolog 9
    U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
    fat mass and obesity associated
    fat mass and obesity-associated protein
    intragenic FTO exon 9 containing transcript
    m6A(m)-demethylase FTO
    mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    mRNA N(6)-methyladenosine demethylase FTO
    tRNA N1-methyl adenine demethylase FTO
    NP_001073901.1
    NP_001350820.1
    NP_001350823.1
    NP_001350825.1
    NP_001350826.1
    NP_001350827.1
    NP_001350828.1
    NP_001350829.1
    NP_001350830.1
    NP_001350832.1
    NP_001350834.1
    NP_001350917.1
    XP_011521616.1
    XP_011521617.1
    XP_011521618.1
    XP_016879143.1
    XP_016879145.1
    XP_016879146.1
    XP_024306205.1
    XP_047290562.1
    XP_047290563.1
    XP_047290564.1
    XP_047290565.1
    XP_054169858.1
    XP_054169859.1
    XP_054169860.1
    XP_054169861.1
    XP_054169862.1
    XP_054169863.1
    XP_054169864.1
    XP_054169865.1
    XP_054169866.1
    XP_054169867.1
    XP_054169868.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012969.2 RefSeqGene

      Range
      5195..422980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080432.3NP_001073901.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 3

      See identical proteins and their annotated locations for NP_001073901.1

      Status: REVIEWED

      Source sequence(s)
      AB051539, AC007347, AK096554, BC001284, BC030798, DA324897, U79260
      Consensus CDS
      CCDS32448.1
      UniProtKB/Swiss-Prot
      A2RUH1, B2RNS0, Q0P676, Q7Z785, Q9C0B1
      UniProtKB/TrEMBL
      B3KU60
      Related
      ENSP00000418823.1, ENST00000471389.6
      Conserved Domains (2) summary
      pfam12933
      Location:40324
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:329498
      FTO_CTD; FTO C-terminal domain
    2. NM_001363891.1NP_001350820.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      B3KU60
      Related
      ENSP00000490516.1, ENST00000637969.1
      Conserved Domains (2) summary
      pfam12933
      Location:40334
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:339508
      FTO_CTD; FTO C-terminal domain
    3. NM_001363894.1NP_001350823.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      B3KU60
      Conserved Domains (2) summary
      pfam12933
      Location:36325
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:329519
      FTO_CTD; FTO C-terminal domain
    4. NM_001363896.1NP_001350825.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      B3KU60
      Conserved Domains (2) summary
      pfam12933
      Location:36325
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:329492
      FTO_CTD; FTO C-terminal domain
    5. NM_001363897.1NP_001350826.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      B3KU60
      Conserved Domains (2) summary
      pfam12933
      Location:16299
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:303472
      FTO_CTD; FTO C-terminal domain
    6. NM_001363898.1NP_001350827.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      B3KU60
      Conserved Domains (2) summary
      pfam12933
      Location:36335
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:330460
      FTO_CTD; FTO C-terminal domain
    7. NM_001363899.1NP_001350828.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      B3KU60
      Conserved Domains (2) summary
      pfam12933
      Location:36287
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:291460
      FTO_CTD; FTO C-terminal domain
    8. NM_001363900.1NP_001350829.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      B3KU60
      Conserved Domains (2) summary
      pfam12933
      Location:36325
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:320450
      FTO_CTD; FTO C-terminal domain
    9. NM_001363901.1NP_001350830.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      B3KU60
      Conserved Domains (2) summary
      pfam12933
      Location:36277
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:281450
      FTO_CTD; FTO C-terminal domain
    10. NM_001363903.1NP_001350832.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      A0A1B0GTY1
      Related
      ENSP00000489886.1, ENST00000636992.1
      Conserved Domains (2) summary
      pfam12933
      Location:36325
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:329411
      FTO_CTD; FTO C-terminal domain
    11. NM_001363905.1NP_001350834.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      Conserved Domains (2) summary
      pfam12933
      Location:21154
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:158327
      FTO_CTD; FTO C-terminal domain
    12. NM_001363988.1NP_001350917.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909
      UniProtKB/TrEMBL
      A0A1B0GV98
      Conserved Domains (2) summary
      pfam12933
      Location:36325
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:329455
      FTO_CTD; FTO C-terminal domain

    RNA

    1. NR_156761.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007347, AC007496, AC007909

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      53703963..54121941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434606.1XP_047290562.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X2

      UniProtKB/TrEMBL
      A0A1B0GV98
    2. XM_047434607.1XP_047290563.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

      UniProtKB/TrEMBL
      A0A1B0GV98
    3. XM_011523314.4XP_011521616.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X4

      UniProtKB/TrEMBL
      A0A1B0GV98
      Conserved Domains (2) summary
      pfam12933
      Location:36335
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:339465
      FTO_CTD; FTO C-terminal domain
    4. XM_011523316.4XP_011521618.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X6

      UniProtKB/TrEMBL
      A0A1B0GV98
      Conserved Domains (2) summary
      pfam12933
      Location:36335
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:339464
      FTO_CTD; FTO C-terminal domain
    5. XM_017023656.3XP_016879145.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X7

      UniProtKB/TrEMBL
      A0A1B0GV98
    6. XM_024450437.2XP_024306205.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X9

      UniProtKB/TrEMBL
      A0A1B0GV98
      Conserved Domains (2) summary
      pfam12933
      Location:36325
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:329454
      FTO_CTD; FTO C-terminal domain
    7. XM_017023654.3XP_016879143.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

      UniProtKB/TrEMBL
      A0A1B0GV98
      Related
      ENST00000636030.1
    8. XM_011523315.4XP_011521617.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X5

      UniProtKB/TrEMBL
      A0A1B0GV98
      Conserved Domains (2) summary
      pfam12933
      Location:36335
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:339465
      FTO_CTD; FTO C-terminal domain
    9. XM_047434608.1XP_047290564.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X5

      UniProtKB/TrEMBL
      A0A1B0GV98
    10. XM_017023657.3XP_016879146.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X8

      UniProtKB/TrEMBL
      A0A1B0GTC5, A0A1B0GV98
      Related
      ENSP00000489641.1, ENST00000636218.1
    11. XM_047434609.1XP_047290565.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X8

      UniProtKB/TrEMBL
      A0A1B0GTC5, A0A1B0GV98
      Related
      ENSP00000489936.1, ENST00000637001.1

    RNA

    1. XR_007064911.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      59501796..59919950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313884.1XP_054169859.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X2

      UniProtKB/TrEMBL
      A0A1B0GV98
    2. XM_054313885.1XP_054169860.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

      UniProtKB/TrEMBL
      A0A1B0GV98
    3. XM_054313886.1XP_054169861.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X4

      UniProtKB/TrEMBL
      A0A1B0GV98
    4. XM_054313889.1XP_054169864.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X6

      UniProtKB/TrEMBL
      A0A1B0GV98
    5. XM_054313890.1XP_054169865.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X7

      UniProtKB/TrEMBL
      A0A1B0GV98
    6. XM_054313893.1XP_054169868.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X9

      UniProtKB/TrEMBL
      A0A1B0GV98
    7. XM_054313883.1XP_054169858.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

      UniProtKB/TrEMBL
      A0A1B0GV98
    8. XM_054313887.1XP_054169862.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X5

      UniProtKB/TrEMBL
      A0A1B0GV98
    9. XM_054313888.1XP_054169863.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X5

      UniProtKB/TrEMBL
      A0A1B0GV98
    10. XM_054313891.1XP_054169866.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X8

      UniProtKB/TrEMBL
      A0A1B0GTC5, A0A1B0GV98
    11. XM_054313892.1XP_054169867.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X8

      UniProtKB/TrEMBL
      A0A1B0GTC5, A0A1B0GV98

    RNA

    1. XR_008484736.1 RNA Sequence