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    HDAC6 histone deacetylase 6 [ Homo sapiens (human) ]

    Gene ID: 10013, updated on 10-Oct-2024

    Summary

    Official Symbol
    HDAC6provided by HGNC
    Official Full Name
    histone deacetylase 6provided by HGNC
    Primary source
    HGNC:HGNC:14064
    See related
    Ensembl:ENSG00000094631 MIM:300272; AllianceGenome:HGNC:14064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD6; JM21; CPBHM; KDAC6; PPP1R90
    Summary
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 18.6), testis (RPKM 15.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HDAC6 in Genome Data Viewer
    Location:
    Xp11.23
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (48801398..48824982)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (48211870..48235478)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48659805..48683392)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ACAA2 pseudogene 1 Neighboring gene RNA, U6 small nuclear 29, pseudogene Neighboring gene CRISPRi-validated e-GATA1 enhancer Neighboring gene CRISPRi-FlowFISH-validated GATA1, HDAC6 and PLP2 regulatory element 1 Neighboring gene CRISPRi-FlowFISH-validated HDAC6, PLP2 and PQBP1 regulatory element Neighboring gene CRISPRi-FlowFISH-validated PLP2 regulatory element 5 Neighboring gene GATA binding protein 1 Neighboring gene CRISPRi-FlowFISH-validated PLP2 regulatory element 6 Neighboring gene CRISPRi-FlowFISH-validated PQBP1 regulatory element 1 Neighboring gene CRISPRi-FlowFISH-validated PLP2 regulatory element 7 Neighboring gene CRISPRi-validated e-HDAC6 enhancer Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:48659902-48660415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20823 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:48689342-48689842 Neighboring gene ES cell expressed Ras Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infectivity is decreased by HDAC6 overexpression in the virus producing cells (HEK293T) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion PubMed
    Envelope transmembrane glycoprotein gp41 env Overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and remarkably prevents HIV-1 gp120/41-dependent cell fusion PubMed
    Tat tat HIV-1 Tat-induced phosphorylation of CHUK (IKKalpha), IKBKB (IKKbeta), and RELA (p65) and NFKBI (IkappaBalpha) degradation are enhanced by HDAC6 in CRT-MG human astroglioma cells suggesting that HDAC6 is responsible for HIV-1 Tat-induced NF-kB activation PubMed
    tat HIV-1 Tat-induced JUN (AP1) DNA binding activity is enhanced by HDAC6 in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat-induced phosphorylation of JUN (AP1) is enhanced by HDAC6 in CRT-MG human astroglioma cells suggesting that HDAC6 participates in HIV-1 Tat-induced regulation of JUN (AP1) signaling cascades PubMed
    tat HIV-1 Tat-induced phosphorylation of MAPK1, MAPK3, MAPK14 and MAPK8 proteins is enhanced by HDAC6 in CRT-MG human astroglioma cells suggesting that HDAC6 is responsible for HIV-1 Tat-induced activation of MAPKs PubMed
    tat HIV-1 Tat-induced increase in expression of ICAM1 is enhanced by HDAC6 in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat-induced increase in expression of CCL2, CXCL8 and CXCL10 is enhanced by HDAC6 in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat increases HDAC6 mRNA and protein expression levels in time- and dose-dependent manner and correlates with a reduced level of acetylated alpha-tubulin in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat and HDAC6 interact in the cytoplasm in a microtubule-dependent manner, which leads to deacetylate Tat at position Lys28 and to inhibit Tat-mediated transactivation PubMed
    Vif vif HIV-1 Vif interacts with endogeneous non-degraded APOBEC3G (and HDAC6) when overexpressed in CEM.NKR.CCR5 cells as demonstrated by co-IP using cell lysates treated with Rnase A (suggesting interaction is direct protein-protein and not tethered by RNA) PubMed
    vif HIV-1 degradation is mediated by HDAC6 overexpression in HEK293T cells and is independent of the APOBEC3G-Vif interaction PubMed
    vif HIV-1 Vif-mediated APOBEC3G ubiquitination and proteasome degradation is inhibited by HDAC6 PubMed
    vif HIV-1 Vif complexes with HDAC6 and APOBEC3G to form a ternary complex as demonstrated by co-IP assay using HEK293T cells lysates PubMed
    vif HIV-1 Vif binds HDAC6 as demonstrated by GST-Vif, HA-HDAC6 pull-down assay PubMed
    vif HIV-1 Vif protein expression is decreased by overexpression of HDAC6 in HEK293T cells without affecting endogeneous CBFB protein levels and this decrease is dependent on the C-terminal Buz domain of HDAC6 protein PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16239

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables acetylspermidine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables misfolded protein binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tau protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tau protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables tau protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin deacetylase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables tubulin deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tubulin deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables tubulin deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tubulin deacetylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aggresome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonal transport of mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to heat TAS
    Traceable Author Statement
    more info
     
    involved_in cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to misfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to parathyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to topologically incorrect protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly TAS
    Traceable Author Statement
    more info
     
    involved_in cilium disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cilium disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in erythrocyte enucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of aggrephagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of axon extension involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hydrogen peroxide metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of oxidoreductase activity IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of protein acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in polyamine deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in polyubiquitinated misfolded protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cholangiocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of tubulin deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deacetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of androgen receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of autophagy of mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of establishment of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule-based movement IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to dexamethasone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to growth factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to misfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in spermidine deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tubulin deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tubulin deacetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in type 2 mitophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in aggresome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in multivesicular body TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone deacetylase 6
    Names
    alpha-tubulin deacetylase HDAC6
    protein deacetylase HDAC6
    protein phosphatase 1, regulatory subunit 90
    tubulin-lysine deacetylase HDAC6
    NP_001308154.1
    NP_001308155.1
    NP_001308156.1
    NP_001308157.1
    NP_001308158.1
    NP_001308159.1
    NP_001308160.1
    NP_006035.2
    XP_047297659.1
    XP_047297660.1
    XP_047297661.1
    XP_047297662.1
    XP_047297663.1
    XP_054182248.1
    XP_054182249.1
    XP_054182250.1
    XP_054182251.1
    XP_054182252.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012560.2 RefSeqGene

      Range
      5671..28580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321225.2NP_001308154.1  histone deacetylase 6 isoform a

      Status: REVIEWED

      Source sequence(s)
      AK302926, AL137696, DC402494
      UniProtKB/TrEMBL
      A0A8V8TKY7, B4DZH6
      Related
      ENST00000697246.1
      Conserved Domains (3) summary
      cd10003
      Location:499849
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:113449
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:11471209
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. NM_001321226.2NP_001308155.1  histone deacetylase 6 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC231533
      Consensus CDS
      CCDS14306.1
      UniProtKB/Swiss-Prot
      O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7
      UniProtKB/TrEMBL
      A0A8V8TKY7
      Related
      ENSP00000402751.2, ENST00000443563.6
      Conserved Domains (4) summary
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam05109
      Location:8381071
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    3. NM_001321227.2NP_001308156.1  histone deacetylase 6 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC231533
      Consensus CDS
      CCDS14306.1
      UniProtKB/Swiss-Prot
      O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7
      UniProtKB/TrEMBL
      A0A8V8TKY7
      Related
      ENSP00000496013.1, ENST00000644068.1
      Conserved Domains (4) summary
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam05109
      Location:8381071
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    4. NM_001321228.2NP_001308157.1  histone deacetylase 6 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC231533
      Consensus CDS
      CCDS14306.1
      UniProtKB/Swiss-Prot
      O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7
      UniProtKB/TrEMBL
      A0A8V8TKY7
      Related
      ENSP00000496046.1, ENST00000643374.2
      Conserved Domains (4) summary
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam05109
      Location:8381071
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    5. NM_001321229.1NP_001308158.1  histone deacetylase 6 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC231533
      Consensus CDS
      CCDS14306.1
      UniProtKB/Swiss-Prot
      O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7
      UniProtKB/TrEMBL
      A0A8V8TKY7
      Related
      ENSP00000365795.3, ENST00000376610.7
      Conserved Domains (4) summary
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam05109
      Location:8381071
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    6. NM_001321230.2NP_001308159.1  histone deacetylase 6 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC231533, BC005872, BC011498
      Consensus CDS
      CCDS87740.1
      UniProtKB/TrEMBL
      A0A2R8YD35, C9J172, C9JEF4, E9PEH1, Q9BRX7
      Related
      ENSP00000496727.1, ENST00000462730.5
      Conserved Domains (1) summary
      cl17011
      Location:99145
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    7. NM_001321231.2NP_001308160.1  histone deacetylase 6 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC231533, BC005872
      Consensus CDS
      CCDS87740.1
      UniProtKB/TrEMBL
      A0A2R8YD35, C9J172, C9JEF4, E9PEH1, Q9BRX7
      Related
      ENSP00000494447.1, ENST00000465269.6
      Conserved Domains (1) summary
      cl17011
      Location:99145
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    8. NM_006044.4NP_006035.2  histone deacetylase 6 isoform b

      See identical proteins and their annotated locations for NP_006035.2

      Status: REVIEWED

      Source sequence(s)
      AC231533, AJ011972, AL137696, DC377684
      Consensus CDS
      CCDS14306.1
      UniProtKB/Swiss-Prot
      O94975, Q6NT75, Q7L3E5, Q96CY0, Q9UBN7
      UniProtKB/TrEMBL
      A0A8V8TKY7
      Related
      ENSP00000334061.5, ENST00000334136.11
      Conserved Domains (4) summary
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam05109
      Location:8381071
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RNA

    1. NR_135591.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC231533
      Related
      ENST00000697890.1
    2. NR_135592.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC231533, AK295884, BC005872
    3. NR_135593.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC231533, BC005872, DA191923

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      48801398..48824982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441703.1XP_047297659.1  histone deacetylase 6 isoform X1

    2. XM_047441704.1XP_047297660.1  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      B4DZH6
    3. XM_047441707.1XP_047297663.1  histone deacetylase 6 isoform X4

      Related
      ENSP00000495932.2, ENST00000480525.6
    4. XM_047441705.1XP_047297661.1  histone deacetylase 6 isoform X3

      Related
      ENSP00000513468.1, ENST00000697886.1
    5. XM_047441706.1XP_047297662.1  histone deacetylase 6 isoform X3

    RNA

    1. XR_007068179.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      48211870..48235478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326274.1XP_054182249.1  histone deacetylase 6 isoform X2

      UniProtKB/TrEMBL
      B4DZH6
    2. XM_054326273.1XP_054182248.1  histone deacetylase 6 isoform X1

    3. XM_054326277.1XP_054182252.1  histone deacetylase 6 isoform X4

    4. XM_054326275.1XP_054182250.1  histone deacetylase 6 isoform X3

    5. XM_054326276.1XP_054182251.1  histone deacetylase 6 isoform X3

    RNA

    1. XR_008485443.1 RNA Sequence