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    KIF14 kinesin family member 14 [ Homo sapiens (human) ]

    Gene ID: 9928, updated on 15-Jan-2024

    Summary

    Official Symbol
    KIF14provided by HGNC
    Official Full Name
    kinesin family member 14provided by HGNC
    Primary source
    HGNC:HGNC:19181
    See related
    Ensembl:ENSG00000118193 MIM:611279; AllianceGenome:HGNC:19181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKS12; MCPH20
    Summary
    This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Broad expression in bone marrow (RPKM 2.3), lymph node (RPKM 1.7) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIF14 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200551497..200620751, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (199808434..199877845, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200520625..200589879, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900414 Neighboring gene uncharacterized LOC124904480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1671 Neighboring gene uncharacterized LOC107985459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1673 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200589147-200589648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200607918-200608633 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:200608609-200609808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1675 Neighboring gene DEAD-box helicase 59 Neighboring gene DDX59 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1677 Neighboring gene MPRA-validated peak646 silencer Neighboring gene calmodulin regulated spectrin associated protein family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200735945-200736445

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0042, MGC142302

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables plus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell proliferation in forebrain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cerebellar Purkinje cell layer structural organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cerebellar cortex development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cerebellar granular layer structural organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cerebral cortex development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hippocampus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in olfactory bulb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of Rap protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF14
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042074.1 RefSeqGene

      Range
      4984..74235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001305792.1NP_001292721.1  kinesin-like protein KIF14 isoform 2

      See identical proteins and their annotated locations for NP_001292721.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL445483, BC098582, BC113742, BC144068, BE644769, BQ425495, CN307042, CR748178, D26361
      UniProtKB/Swiss-Prot
      Q15058
      Conserved Domains (5) summary
      smart00129
      Location:1217
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:312409
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl22853
      Location:1217
      Motor_domain; Myosin and Kinesin motor domain
      pfam11068
      Location:471531
      YlqD; YlqD protein
      pfam16183
      Location:214332
      Kinesin_assoc; Kinesin-associated
    2. NM_014875.3NP_055690.1  kinesin-like protein KIF14 isoform 1

      See identical proteins and their annotated locations for NP_055690.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL445483, BC098582, D26361
      Consensus CDS
      CCDS30963.1
      UniProtKB/Swiss-Prot
      Q14CI8, Q15058, Q4G0A5, Q5T1W3
      Related
      ENSP00000356319.4, ENST00000367350.5
      Conserved Domains (5) summary
      smart00129
      Location:358708
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:803900
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:357708
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9621022
      YlqD; YlqD protein
      pfam16183
      Location:705823
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      200551497..200620751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436198.1XP_047292154.1  kinesin-like protein KIF14 isoform X5

    2. XM_047436190.1XP_047292146.1  kinesin-like protein KIF14 isoform X2

    3. XM_011510232.3XP_011508534.1  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_011508534.1

      UniProtKB/Swiss-Prot
      Q14CI8, Q15058, Q4G0A5, Q5T1W3
      Related
      ENSP00000483069.1, ENST00000614960.4
      Conserved Domains (5) summary
      smart00129
      Location:358708
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:803900
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:357708
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9621022
      YlqD; YlqD protein
      pfam16183
      Location:705823
      Kinesin_assoc; Kinesin-associated
    4. XM_017003007.2XP_016858496.1  kinesin-like protein KIF14 isoform X7

      Conserved Domains (3) summary
      cd00060
      Location:614711
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR02168
      Location:733884
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01365
      Location:168519
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    5. XM_047436199.1XP_047292155.1  kinesin-like protein KIF14 isoform X6

    6. XM_047436195.1XP_047292151.1  kinesin-like protein KIF14 isoform X4

    7. XM_017003006.2XP_016858495.1  kinesin-like protein KIF14 isoform X3

    8. XM_011510235.3XP_011508537.1  kinesin-like protein KIF14 isoform X5

      Conserved Domains (5) summary
      smart00129
      Location:234584
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:679776
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:233584
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:838898
      YlqD; YlqD protein
      pfam16183
      Location:581699
      Kinesin_assoc; Kinesin-associated
    9. XM_011510233.3XP_011508535.1  kinesin-like protein KIF14 isoform X2

      Conserved Domains (5) summary
      smart00129
      Location:330680
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:775872
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:329680
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:934994
      YlqD; YlqD protein
      pfam16183
      Location:677795
      Kinesin_assoc; Kinesin-associated
    10. XM_047436181.1XP_047292137.1  kinesin-like protein KIF14 isoform X2

    11. XM_011510231.3XP_011508533.1  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_011508533.1

      UniProtKB/Swiss-Prot
      Q14CI8, Q15058, Q4G0A5, Q5T1W3
      Conserved Domains (5) summary
      smart00129
      Location:358708
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:803900
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:357708
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9621022
      YlqD; YlqD protein
      pfam16183
      Location:705823
      Kinesin_assoc; Kinesin-associated
    12. XM_047436197.1XP_047292153.1  kinesin-like protein KIF14 isoform X5

    13. XM_047436184.1XP_047292140.1  kinesin-like protein KIF14 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      199808434..199877845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339956.1XP_054195931.1  kinesin-like protein KIF14 isoform X1

      UniProtKB/TrEMBL
      A0A384P5W4
    2. XM_054339960.1XP_054195935.1  kinesin-like protein KIF14 isoform X2

    3. XM_054339964.1XP_054195939.1  kinesin-like protein KIF14 isoform X5

    4. XM_054339967.1XP_054195942.1  kinesin-like protein KIF14 isoform X7

    5. XM_054339966.1XP_054195941.1  kinesin-like protein KIF14 isoform X6

    6. XM_054339962.1XP_054195937.1  kinesin-like protein KIF14 isoform X4

    7. XM_054339961.1XP_054195936.1  kinesin-like protein KIF14 isoform X3

    8. XM_054339963.1XP_054195938.1  kinesin-like protein KIF14 isoform X5

    9. XM_054339957.1XP_054195932.1  kinesin-like protein KIF14 isoform X2

    10. XM_054339958.1XP_054195933.1  kinesin-like protein KIF14 isoform X2

    11. XM_054339955.1XP_054195930.1  kinesin-like protein KIF14 isoform X1

      UniProtKB/TrEMBL
      A0A384P5W4
    12. XM_054339965.1XP_054195940.1  kinesin-like protein KIF14 isoform X5

    13. XM_054339959.1XP_054195934.1  kinesin-like protein KIF14 isoform X2