U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    SEC61A1 SEC61 translocon subunit alpha 1 [ Homo sapiens (human) ]

    Gene ID: 29927, updated on 1-Mar-2024

    Summary

    Official Symbol
    SEC61A1provided by HGNC
    Official Full Name
    SEC61 translocon subunit alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:18276
    See related
    Ensembl:ENSG00000058262 MIM:609213; AllianceGenome:HGNC:18276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNFJ4; SEC61; ADTKD5; CVID15; HSEC61; SEC61A
    Summary
    The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 81.0), placenta (RPKM 70.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SEC61A1 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (128051641..128071683)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (130786219..130806258)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127770484..127790526)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986129 Neighboring gene uncharacterized LOC124909427 Neighboring gene kelch repeat and BTB domain containing 12 Neighboring gene RNA, 5S ribosomal pseudogene 139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127730388-127730888 Neighboring gene uncharacterized LOC102723759 Neighboring gene Sharpr-MPRA regulatory region 3038 Neighboring gene CRISPRi-FlowFISH-validated RPN1 regulatory element 1 Neighboring gene Sharpr-MPRA regulatory regions 9818 and 11773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14701 Neighboring gene RUVBL1 antisense RNA 1 Neighboring gene RuvB like AAA ATPase 1 Neighboring gene RNA, U2 small nuclear 37, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify Sec61 alpha 1 subunit (SEC61A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env HIV-1 gp120 is identified to have a physical interaction with Sec61 alpha 1 subunit (SEC61A1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with Sec61 alpha 1 subunit (SEC61A1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify Sec61 alpha 1 subunit (SEC61A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify Sec61 alpha 1 subunit (SEC61A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify Sec61 alpha 1 subunit (SEC61A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein transport protein Sec61 subunit alpha isoform 1
    Names
    SEC61 translocon alpha 1 subunit
    Sec61 alpha 1 subunit
    Sec61 alpha-1
    protein transport protein SEC61 alpha subunit
    protein transport protein Sec61 subunit alpha
    sec61 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052786.1 RefSeqGene

      Range
      5069..24315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001400328.1NP_001387257.1  protein transport protein Sec61 subunit alpha isoform 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011311
      Consensus CDS
      CCDS93366.1
      UniProtKB/TrEMBL
      A0A8V8TMZ5, B4DR61
      Related
      ENSP00000418493.1, ENST00000464451.5
    2. NM_001400329.1NP_001387258.1  protein transport protein Sec61 subunit alpha isoform 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC011311
      Consensus CDS
      CCDS93367.1
      UniProtKB/TrEMBL
      A0A8V8TMZ5, C9JXC6
      Related
      ENSP00000419172.2, ENST00000481210.6
    3. NM_013336.4NP_037468.1  protein transport protein Sec61 subunit alpha isoform 1 isoform 1

      See identical proteins and their annotated locations for NP_037468.1

      Status: REVIEWED

      Source sequence(s)
      AF084458, AK027423, AK027452
      Consensus CDS
      CCDS3046.1
      UniProtKB/Swiss-Prot
      P38378, P57726, P61619, Q5JPF8, Q8N0Z4, Q8N3U3, Q8NC71, Q9BU16, Q9Y2R3
      UniProtKB/TrEMBL
      A0A8V8TMZ5, B3KNF6, D3DNB2
      Related
      ENSP00000243253.3, ENST00000243253.8
      Conserved Domains (1) summary
      PTZ00219
      Location:1471
      PTZ00219; Sec61 alpha subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      128051641..128071683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      130786219..130806258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)