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    PAP1 phosphatidic acid phosphatase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814646, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAP1
    Official Full Name
    phosphatidic acid phosphatase 1
    Primary source
    TAIR:AT2G01180
    Locus tag
    AT2G01180
    See related
    Araport:AT2G01180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATLPP1; ATPAP1; F10A8.6; F10A8_6; LIPID PHOSPHATE PHOSPHATASE 1; LPP1; phosphatidic acid phosphatase 1
    Summary
    Encodes phosphatidate phosphatase. Up-regulated by genotoxic stress (gamma ray or UV-B) and elicitor treatments with mastoparan and harpin. Expressed in roots and leaves.
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    Genomic context

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    See PAP1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (106621..108829, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene bidirectional amino acid transporter 1 Neighboring gene uncharacterized protein Neighboring gene Octicosapeptide/Phox/Bem1p family protein Neighboring gene indole-3-acetic acid inducible 32 Neighboring gene Leucine-rich repeat protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide Identification of PAP1 Direct Targets in Regulating Seed Anthocyanin Biosynthesis in Arabidopsis. Guo Y, et al. Int J Mol Sci, 2023 Nov 7. PMID 38003239, Free PMC Article
    2. Lipid phosphate phosphatases in Arabidopsis. Regulation of the AtLPP1 gene in response to stress. Pierrugues O, et al. J Biol Chem, 2001 Jun 8. PMID 11278556
    3. The plasmodesmal protein PDLP1 localises to haustoria-associated membranes during downy mildew infection and regulates callose deposition. Caillaud MC, et al. PLoS Pathog, 2014 Oct. PMID 25393742, Free PMC Article
    4. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-Wide Identification of PAP1 Direct Targets in Regulating Seed Anthocyanin Biosynthesis in Arabidopsis.
      Title: Genome-Wide Identification of PAP1 Direct Targets in Regulating Seed Anthocyanin Biosynthesis in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335038.1
    NM_001335041.1
    NM_001335042.1
    NM_001335043.1
    NM_126179.5
    NM_201660.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid metabolic process NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within response to UV-B IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidic acid phosphatase 1
    NP_001318171.1
    • phosphatidic acid phosphatase 1 (PAP1); FUNCTIONS IN: phosphatidate phosphatase activity; INVOLVED IN: phospholipid metabolic process, response to stress; LOCATED IN: plasma membrane, integral to plasma membrane; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidic acid phosphatase/chloroperoxidase, N-terminal (InterPro:IPR016118), Phosphatidic acid phosphatase type 2/haloperoxidase (InterPro:IPR000326); BEST Arabidopsis thaliana protein match is: lipid phosphate phosphatase 3 (TAIR:AT3G02600.1); Has 2118 Blast hits to 2110 proteins in 392 species: Archae - 9; Bacteria - 357; Metazoa - 920; Fungi - 399; Plants - 198; Viruses - 3; Other Eukaryotes - 232 (source: NCBI BLink).
    NP_973389.1
    • phosphatidic acid phosphatase 1 (PAP1); FUNCTIONS IN: phosphatidate phosphatase activity; INVOLVED IN: phospholipid metabolic process, response to stress; LOCATED IN: plasma membrane, integral to plasma membrane; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidic acid phosphatase/chloroperoxidase, N-terminal (InterPro:IPR016118), Phosphatidic acid phosphatase type 2/haloperoxidase (InterPro:IPR000326); BEST Arabidopsis thaliana protein match is: lipid phosphate phosphatase 3 (TAIR:AT3G02600.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      106621..108829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335040.1 → NP_001323950.1  phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EC91, Q8H0G3, Q8LDP8, Q945N3, Q94LY6, Q9ZU49
      UniProtKB/TrEMBL
      A0A5S9WW89, A0A654EQX5
      Conserved Domains (1) summary
      PLN02715
      Location:1 → 327
      PLN02715; lipid phosphate phosphatase

    2. NM_001335039.1 → NP_001323948.1  phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYQ5

    3. NM_001335038.1 → NP_001318171.1  phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EC91, Q8H0G3, Q8LDP8, Q945N3, Q94LY6, Q9ZU49
      UniProtKB/TrEMBL
      A0A5S9WW89, A0A654EQX5
      Conserved Domains (1) summary
      PLN02715
      Location:1 → 327
      PLN02715; lipid phosphate phosphatase

    4. NM_001335041.1 → NP_001323949.1  phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VSS9
      Conserved Domains (1) summary
      PLN02715
      Location:1 → 302
      PLN02715; lipid phosphate phosphatase

    5. NM_001335042.1 → NP_001323952.1  phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYJ4

    6. NM_001335043.1 → NP_001323951.1  phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYQ5

    7. NM_126179.5 → NP_565255.1  phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EC91, Q8H0G3, Q8LDP8, Q945N3, Q94LY6, Q9ZU49
      UniProtKB/TrEMBL
      A0A5S9WW89, A0A654EQX5
      Conserved Domains (1) summary
      PLN02715
      Location:1 → 327
      PLN02715; lipid phosphate phosphatase

    8. NM_201660.2 → NP_973389.1  phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973389.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VSS9
      Conserved Domains (1) summary
      PLN02715
      Location:1 → 302
      PLN02715; lipid phosphate phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZU49.2

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