IL22RA1 interleukin 22 receptor subunit alpha 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL22RA1provided by HGNC
Official Full Name: interleukin 22 receptor subunit alpha 1provided by HGNC
Primary source: HGNC:HGNC:13700
See related: Ensembl:ENSG00000142677 MIM:605457; AllianceGenome:HGNC:13700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL22R; CRF2-9; IL22R1
Summary: The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
Expression: Biased expression in pancreas (RPKM 15.5), skin (RPKM 14.3) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (24119771..24143140, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (23957480..23980846, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (24446261..24469630, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis.
Title: Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis.
Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
Title: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
Title: Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
Title: Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection.
Title: Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection.
Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
Title: Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
Increased expression of interleukin-22 and its receptor is relevant to poor prognosis in laryngeal squamous cell carcinoma: A case control trial.
Title: Increased expression of interleukin-22 and its receptor is relevant to poor prognosis in laryngeal squamous cell carcinoma: A case control trial.
Targeting IL-22 and IL-22R protects against experimental osteoarthritis.
Title: Targeting IL-22 and IL-22R protects against experimental osteoarthritis.
High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer.
Title: High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer.
Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis.
Title: Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of interleukin 22 receptor, alpha 1 (IL22RA1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interferon receptor activity	TAS Traceable Author Statement more info	PubMed
enables interleukin-20 binding	IEA Inferred from Electronic Annotation more info
enables interleukin-22 receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in interleukin-22-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-22 receptor subunit alpha-1

Names: IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; interleukin 22 receptor, alpha 1; zcytoR11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021258.4 → NP_067081.2 interleukin-22 receptor subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_067081.2

Status: REVIEWED

Source sequence(s)

AK313971, BC029273

Consensus CDS

CCDS247.1

UniProtKB/Swiss-Prot

A8K839, B2R9Y9, Q8N6P7, Q9HB22

UniProtKB/TrEMBL

B4E2V9

Related

ENSP00000270800.1, ENST00000270800.2

Conserved Domains (3) summary

PHA03247
Location:305 → 529

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:293 → 401

PRK10263; DNA translocase FtsK; Provisional

pfam01108
Location:4 → 107

Tissue_fac; Tissue factor