TRIM3 tripartite motif containing 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM3provided by HGNC
Official Full Name: tripartite motif containing 3provided by HGNC
Primary source: HGNC:HGNC:10064
See related: Ensembl:ENSG00000110171 MIM:605493; AllianceGenome:HGNC:10064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BERP; HAC1; RNF22; RNF97
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (6448613..6474459, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (6507075..6532930, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (6469843..6495689, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling.
Title: Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling.
Advances in the antitumor mechanisms of tripartite motif-containing protein 3.
Title: Advances in the antitumor mechanisms of tripartite motif-containing protein 3.
TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.
Title: TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.
Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
Title: Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
TRIM3 Inhibits H2O2-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination.
Title: TRIM3 Inhibits H(2)O(2)-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination.
TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression.
Title: TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression.
Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.
Title: Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.
TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.
Title: TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.
miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3.
Title: miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3.
Foxo3a exerted inhibitory effects on LPS-induced proliferation and inflammation through increasing TRIM3 transcription.
Title: Forkhead box o3a suppresses lipopolysaccharide-stimulated proliferation and inflammation in fibroblast-like synoviocytes through regulating tripartite motif-containing protein 3.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2266E (e-PCR)
- UniSTS:46848

RH12618 (e-PCR)
- UniSTS:89873

RH91168 (e-PCR)
- UniSTS:85551

D11S4905 (e-PCR)
- UniSTS:76599

SHGC-30684 (e-PCR)
- UniSTS:6728

RH44846 (e-PCR)
- UniSTS:5208

D11S2391 (e-PCR)
- UniSTS:50314

STS-Z40796 (e-PCR)
- UniSTS:31171

RH47384 (e-PCR)
- UniSTS:60909

RH71141 (e-PCR)
- UniSTS:60910

SGC34546 (e-PCR)
- UniSTS:60911

WI-22461 (e-PCR)
- UniSTS:48639

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 3 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tripartite motif-containing protein 3

Names: RING finger protein 97; brain expressed ring finger; brain-expressed RING finger protein; ring finger protein 22; tripartite motif protein TRIM3

NP_001234935.1

EC 2.3.2.27

NP_001234936.1

EC 2.3.2.27

NP_006449.2

EC 2.3.2.27

NP_150594.2

EC 2.3.2.27

XP_016872587.1

EC 2.3.2.27

XP_024304096.1

EC 2.3.2.27

XP_047282213.1

EC 2.3.2.27

XP_047282214.1

EC 2.3.2.27

XP_047282215.1

EC 2.3.2.27

XP_047282217.1

EC 2.3.2.27

XP_047282218.1

EC 2.3.2.27

XP_054223451.1

EC 2.3.2.27

XP_054223452.1

EC 2.3.2.27

XP_054223453.1

EC 2.3.2.27

XP_054223454.1

EC 2.3.2.27

XP_054223455.1

EC 2.3.2.27

XP_054223456.1

EC 2.3.2.27

XP_054223457.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001248006.2 → NP_001234935.1 tripartite motif-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_001234935.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains a different 5' UTR, compared to variant 1. Variants 1, 2, and 4 encode the same protein (isoform 1).

Source sequence(s)

AC084337

Consensus CDS

CCDS7764.1

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

UniProtKB/TrEMBL

B7Z5Y8

Related

ENSP00000433102.1, ENST00000525074.5

Conserved Domains (5) summary

smart00502
Location:158 → 284

BBC; B-Box C-terminal domain

smart00336
Location:110 → 151

BBOX; B-Box-type zinc finger

smart00557
Location:322 → 419

IG_FLMN; Filamin-type immunoglobulin domains

cd14960
Location:471 → 744

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16768
Location:19 → 63

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
NM_001248007.2 → NP_001234936.1 tripartite motif-containing protein 3 isoform 2

See identical proteins and their annotated locations for NP_001234936.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks several exons, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AK291396, AK298843, AK299586, AL122053, BC096827

Consensus CDS

CCDS58115.1

UniProtKB/Swiss-Prot

O75382

UniProtKB/TrEMBL

B7Z5Y8

Related

ENSP00000445460.1, ENST00000536344.5

Conserved Domains (4) summary

smart00502
Location:39 → 165

BBC; B-Box C-terminal domain

smart00557
Location:203 → 300

IG_FLMN; Filamin-type immunoglobulin domains

cd14960
Location:352 → 625

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cl00034
Location:2 → 34

Bbox_SF; B-box-type zinc finger superfamily
NM_006458.4 → NP_006449.2 tripartite motif-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_006449.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 4 encode the same protein (isoform 1).

Source sequence(s)

AK291396, AK299586, AL122053, BC096827, BI916995

Consensus CDS

CCDS7764.1

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

UniProtKB/TrEMBL

B7Z5Y8

Related

ENSP00000352508.3, ENST00000359518.7

Conserved Domains (5) summary

smart00502
Location:158 → 284

BBC; B-Box C-terminal domain

smart00336
Location:110 → 151

BBOX; B-Box-type zinc finger

smart00557
Location:322 → 419

IG_FLMN; Filamin-type immunoglobulin domains

cd14960
Location:471 → 744

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16768
Location:19 → 63

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
NM_033278.4 → NP_150594.2 tripartite motif-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_150594.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform 1).

Source sequence(s)

AL122053, BC096827, BM758857, DA089323, DA347370, DB344600

Consensus CDS

CCDS7764.1

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

UniProtKB/TrEMBL

B7Z5Y8

Related

ENSP00000340797.3, ENST00000345851.8

Conserved Domains (5) summary

smart00502
Location:158 → 284

BBC; B-Box C-terminal domain

smart00336
Location:110 → 151

BBOX; B-Box-type zinc finger

smart00557
Location:322 → 419

IG_FLMN; Filamin-type immunoglobulin domains

cd14960
Location:471 → 744

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16768
Location:19 → 63

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

6448613..6474459 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426261.1 → XP_047282217.1 tripartite motif-containing protein 3 isoform X4
XM_024448328.2 → XP_024304096.1 tripartite motif-containing protein 3 isoform X3

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

UniProtKB/TrEMBL

B7Z5Y8

Conserved Domains (5) summary

smart00502
Location:158 → 284

BBC; B-Box C-terminal domain

smart00336
Location:110 → 151

BBOX; B-Box-type zinc finger

smart00557
Location:322 → 419

IG_FLMN; Filamin-type immunoglobulin domains

cd14960
Location:471 → 744

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16768
Location:19 → 63

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
XM_017017098.3 → XP_016872587.1 tripartite motif-containing protein 3 isoform X3

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

UniProtKB/TrEMBL

B7Z5Y8

Conserved Domains (5) summary

smart00502
Location:158 → 284

BBC; B-Box C-terminal domain

smart00336
Location:110 → 151

BBOX; B-Box-type zinc finger

smart00557
Location:322 → 419

IG_FLMN; Filamin-type immunoglobulin domains

cd14960
Location:471 → 744

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16768
Location:19 → 63

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
XM_047426258.1 → XP_047282214.1 tripartite motif-containing protein 3 isoform X2
XM_047426257.1 → XP_047282213.1 tripartite motif-containing protein 3 isoform X1
XM_047426259.1 → XP_047282215.1 tripartite motif-containing protein 3 isoform X3

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
XM_047426262.1 → XP_047282218.1 tripartite motif-containing protein 3 isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

6507075..6532930 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367481.1 → XP_054223456.1 tripartite motif-containing protein 3 isoform X4
XM_054367478.1 → XP_054223453.1 tripartite motif-containing protein 3 isoform X3

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
XM_054367479.1 → XP_054223454.1 tripartite motif-containing protein 3 isoform X3

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
XM_054367477.1 → XP_054223452.1 tripartite motif-containing protein 3 isoform X2
XM_054367476.1 → XP_054223451.1 tripartite motif-containing protein 3 isoform X1
XM_054367480.1 → XP_054223455.1 tripartite motif-containing protein 3 isoform X3

UniProtKB/Swiss-Prot

B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
XM_054367482.1 → XP_054223457.1 tripartite motif-containing protein 3 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033279.1: Suppressed sequence

Description

NM_033279.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.