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    elnb elastin b [ Danio rerio (zebrafish) ]

    Gene ID: 558461, updated on 28-Oct-2024

    Summary

    Official Symbol
    elnbprovided by ZNC
    Official Full Name
    elastin bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061212-2
    See related
    Ensembl:ENSDARG00000069017 AllianceGenome:ZFIN:ZDB-GENE-061212-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eln2
    Summary
    Predicted to be an extracellular matrix structural constituent. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Is expressed in cranium; heart; swim bladder; and ventral aorta. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; aortic disease (multiple); autoimmune disease (multiple); cutis laxa (multiple); and retinal disease (multiple). Orthologous to human ELN (elastin). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See elnb in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (40836373..40880394, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (40816450..40857305, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene zgc:162239 Neighboring gene LIM domain kinase 1b Neighboring gene Yip1 domain family, member 5 Neighboring gene potassium channel tetramerization domain containing 16b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    elastin b
    Names
    tropoelastin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048064.2NP_001041529.2  elastin b precursor

      Status: VALIDATED

      Source sequence(s)
      BX649570, CU302322
      UniProtKB/TrEMBL
      A0A8M1NAS7
      Related
      ENSDARP00000123914.1, ENSDART00000137696.4
      Conserved Domains (1) summary
      cl01807
      Location:12781341
      DUF1517; Protein of unknown function (DUF1517)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      40836373..40880394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352794.3XP_017208283.1  elastin b isoform X5

      UniProtKB/TrEMBL
      A0A8M6YV34
    2. XM_068215896.1XP_068071997.1  elastin b isoform X2

    3. XM_068215898.1XP_068071999.1  elastin b isoform X7

    4. XM_021468860.2XP_021324535.1  elastin b isoform X6

      UniProtKB/TrEMBL
      A0A8M9PTX8
      Conserved Domains (2) summary
      pfam05642
      Location:470530
      Sporozoite_P67; Sporozoite P67 surface antigen
      cl01807
      Location:12781341
      DUF1517; Protein of unknown function (DUF1517)
    5. XM_017352791.3XP_017208280.1  elastin b isoform X3

      UniProtKB/TrEMBL
      A0A8M6YUG6
    6. XM_017352793.3XP_017208282.1  elastin b isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z2Z8
    7. XM_017352790.3XP_017208279.1  elastin b isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z3N0