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    grap2b GRB2 related adaptor protein 2b [ Danio rerio (zebrafish) ]

    Gene ID: 393651, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grap2bprovided by ZNC
    Official Full Name
    GRB2 related adaptor protein 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1485
    See related
    Ensembl:ENSDARG00000101169 AllianceGenome:ZFIN:ZDB-GENE-040426-1485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:65942
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human GRAP2 (GRB2 related adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See grap2b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (427317..442276, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (404610..419585, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene cytohesin 4b Neighboring gene family with sequence similarity 83 member Fb Neighboring gene voltage-dependent T-type calcium channel subunit alpha-1I-like Neighboring gene voltage-dependent T-type calcium channel subunit alpha-1I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Macrophage-specific gene functions in Spi1-directed innate immunity. Zakrzewska A, et al. Blood, 2010 Jul 22. PMID 20424185
    2. CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns. Stergas HR, et al. FEBS Lett, 2024 Feb. PMID 38058169
    3. Single-cell transcriptome analysis of fish immune cells provides insight into the evolution of vertebrate immune cell types. Carmona SJ, et al. Genome Res, 2017 Mar. PMID 28087841, Free PMC Article
    4. Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Demin KA, et al. Sci Rep, 2020 Nov 17. PMID 33203921, Free PMC Article
    5. Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Chestnut B, et al. Dev Dyn, 2020 Feb. PMID 31705559, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC65942

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GRB2-related adapter protein 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200678.2 → NP_956972.1  GRB2-related adapter protein 2b

      See identical proteins and their annotated locations for NP_956972.1

      Status: VALIDATED

      Source sequence(s)
      CU659674, EH590682
      UniProtKB/TrEMBL
      A0A8M1PEV1, Q6PE32
      Related
      ENSDARP00000133722.1, ENSDART00000169789.2
      Conserved Domains (2) summary
      cd09941
      Location:54 → 147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cl17036
      Location:197 → 248
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      427317..442276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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