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    CCNG1 cyclin G1 [ Homo sapiens (human) ]

    Gene ID: 900, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CCNG1provided by HGNC
    Official Full Name
    cyclin G1provided by HGNC
    Primary source
    HGNC:HGNC:1592
    See related
    Ensembl:ENSG00000113328 MIM:601578; AllianceGenome:HGNC:1592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCNG
    Summary
    The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum (RPKM 74.2), small intestine (RPKM 61.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCNG1 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (163437571..163457640)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (163972739..163983375)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (162864577..162875205)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L57 pseudogene 6 Neighboring gene uncharacterized LOC105377700 Neighboring gene NANOG hESC enhancer GRCh37_chr5:162605640-162606379 Neighboring gene uncharacterized LOC124901125 Neighboring gene MPRA-validated peak5562 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:162756879-162757856 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:162757857-162758834 Neighboring gene NANOG hESC enhancer GRCh37_chr5:162800374-162800875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16589 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:162864697-162865274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16590 Neighboring gene NudC domain containing 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:162929934-162930742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:162932358-162933164 Neighboring gene HMMR antisense RNA 1 Neighboring gene hyaluronan mediated motility receptor Neighboring gene methionine adenosyltransferase 2 non-catalytic beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The role of progesterone and its receptor on cyclin G1 expression in endometrial carcinoma cells. Liu F, et al. Reprod Sci, 2012 Nov. PMID 22649121
    2. Effects of expression of exogenous cyclin G1 on proliferation of human endometrial carcinoma cells. Liu F, et al. Chin J Physiol, 2013 Apr 30. PMID 23589924
    3. Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. Reimer CL, et al. J Biol Chem, 1999 Apr 16. PMID 10196184
    4. The negative role of cyclin G in ATM-dependent p53 activation. Ohtsuka T, et al. Oncogene, 2004 Jul 8. PMID 15077171
    5. Influence of Confounding Factors on Radiation Dose Estimation Using In Vivo Validated Transcriptional Biomarkers. Cruz-Garcia L, et al. Health Phys, 2018 Jul. PMID 29787434, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1.
      Title: PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1.
    2. Long noncoding RNA OIP5AS1 facilitates the progression of ovarian cancer via the miR1283p/CCNG1 axis.
      Title: Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis.
    3. Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis.
      Title: Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis.
    4. MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression.
      Title: MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression.
    5. MicroRNA-23a inhibits the growth of papillary thyroid carcinoma via regulating cyclin G1.
      Title: MicroRNA-23a inhibits the growth of papillary thyroid carcinoma via regulating cyclin G1.
    6. Methylation-associated miR-9 down-regulation is probably one of the key mechanisms for paclitaxel resistance in EOC cells, via targeting CCNG1.
      Title: Methylation-associated Has-miR-9 deregulation in paclitaxel- resistant epithelial ovarian carcinoma.
    7. Our findings indicate that CCNG1 overexpression, which is associated with poor clinical prognosis of high-grade serous ovarian cancer(HGSOC), can promote metastasis and chemotherapy resistance via the P53mt-Notch3 pathway. Our data also suggest that CCNG1 inhibitors represent a novel approach to increase chemotherapy efficacy in HGSOC and potentially improve patient outcomes.
      Title: CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression.
    8. Cyclin G1 (CG1), an atypical cyclin, promoted G2-M arrest in proximal tubular cell and up-regulated target of rapamycin (TOR)-autophagy spatial coupling compartment formation.
      Title: Cyclin G1 and TASCC regulate kidney epithelial cell G(2)-M arrest and fibrotic maladaptive repair.
    9. our findings revealed that the C/EBPbeta-LINC01133 axis performs an oncogenic function in pancreatic ductal adenocarcinoma by activating CCNG1
      Title: The C/EBPβ-LINC01133 axis promotes cell proliferation in pancreatic ductal adenocarcinoma through upregulation of CCNG1.
    10. miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous carcinoma cells.
      Title: miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to gravity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in syncytium formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-G1
    Names
    cyclin-G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364015.1 → NP_001350944.1  cyclin-G1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC112205
      Consensus CDS
      CCDS4360.1
      UniProtKB/Swiss-Prot
      B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32
      Conserved Domains (1) summary
      cd20583
      Location:51 → 148
      CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins

    2. NM_001364018.1 → NP_001350947.1  cyclin-G1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC112205
      Conserved Domains (1) summary
      pfam00134
      Location:20 → 149
      Cyclin_N; Cyclin, N-terminal domain

    3. NM_001364019.1 → NP_001350948.1  cyclin-G1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC112205
      Conserved Domains (1) summary
      pfam00134
      Location:20 → 149
      Cyclin_N; Cyclin, N-terminal domain

    4. NM_001364020.1 → NP_001350949.1  cyclin-G1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC112205
      Conserved Domains (1) summary
      pfam00134
      Location:20 → 149
      Cyclin_N; Cyclin, N-terminal domain

    5. NM_001364021.1 → NP_001350950.1  cyclin-G1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC112205
      Conserved Domains (1) summary
      cl00050
      Location:30 → 91
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    6. NM_001364022.1 → NP_001350951.1  cyclin-G1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC112205
      Consensus CDS
      CCDS93817.1
      UniProtKB/TrEMBL
      E7ERZ1
      Related
      ENSP00000424315.1, ENST00000512163.5

    7. NM_001364023.1 → NP_001350952.1  cyclin-G1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC112205
      Consensus CDS
      CCDS93817.1
      UniProtKB/TrEMBL
      E7ERZ1

    8. NM_004060.4 → NP_004051.1  cyclin-G1 isoform a

      See identical proteins and their annotated locations for NP_004051.1

      Status: REVIEWED

      Source sequence(s)
      BC000196, BX644635
      Consensus CDS
      CCDS4360.1
      UniProtKB/Swiss-Prot
      B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32
      Related
      ENSP00000344635.2, ENST00000340828.7
      Conserved Domains (1) summary
      cd20583
      Location:51 → 148
      CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins

    9. NM_199246.2 → NP_954854.1  cyclin-G1 isoform a

      See identical proteins and their annotated locations for NP_954854.1

      Status: REVIEWED

      Source sequence(s)
      BC000196, BM479568
      Consensus CDS
      CCDS4360.1
      UniProtKB/Swiss-Prot
      B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32
      Conserved Domains (1) summary
      cd20583
      Location:51 → 148
      CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins

    RNA

    1. NR_157051.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112205, BX538035

    2. NR_157052.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112205

    3. NR_157053.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112205

    4. NR_157054.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112205

    5. NR_157055.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112205

    6. NR_157056.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112205

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      163437571..163457640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417862.1 → XP_047273818.1  cyclin-G1 isoform X1

    RNA

    1. XR_007058657.1 RNA Sequence

    2. XR_007058655.1 RNA Sequence

    3. XR_007058656.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      163972739..163983375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353746.1 → XP_054209721.1  cyclin-G1 isoform X1

    RNA

    1. XR_008487192.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51959.2 GenPept UniProtKB/Swiss-Prot:P51959

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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