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    STYX serine/threonine/tyrosine interacting protein [ Homo sapiens (human) ]

    Gene ID: 6815, updated on 2-Nov-2024

    Summary

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    Official Symbol
    STYXprovided by HGNC
    Official Full Name
    serine/threonine/tyrosine interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:11447
    See related
    Ensembl:ENSG00000198252 MIM:615814; AllianceGenome:HGNC:11447
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STYX in Genome Data Viewer
    Location:
    14q22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (52730166..52774989)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (46937959..46982783)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53196884..53241707)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:53130319-53130927 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:53161801-53162302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5747 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5748 Neighboring gene Sharpr-MPRA regulatory region 400 Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:53218646-53218797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8397 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr14:53257919-53258432 and GRCh37_chr14:53258433-53258947 Neighboring gene uncharacterized LOC105370500 Neighboring gene glucosamine-phosphate N-acetyltransferase 1 Neighboring gene COP9 signalosome subunit 9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. STYX: a versatile pseudophosphatase. Reiterer V, et al. Biochem Soc Trans, 2017 Apr 15. PMID 28408485
    2. STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch-mTOR signaling pathway. Liu L, et al. Biosci Rep, 2020 Apr 30. PMID 32239181, Free PMC Article
    3. A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. Wishart MJ, et al. J Biol Chem, 1995 Nov 10. PMID 7592916
    4. Pseudophosphatase STYX promotes tumor growth and metastasis by inhibiting FBXW7 function in colorectal cancer. He D, et al. Cancer Lett, 2019 Jul 10. PMID 30981757
    5. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. Dayton MA, et al. Recept Signal Transduct, 1997. PMID 9633825

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch-mTOR signaling pathway.
      Title: STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch-mTOR signaling pathway.
    2. STYX bound to the F-box and WD repeat domain-containing7 (FBXW7) protein and inhibited its function. Co-regulation of STYX and FBXW7 expression reversed the biological changes mediated by regulation of STYX expression alone in CRC cells.
      Title: Pseudophosphatase STYX promotes tumor growth and metastasis by inhibiting FBXW7 function in colorectal cancer.
    3. The authors show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex.
      Title: The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
    4. Results suggest that STYX is a pseudophosphatase that uses the 'competitor' and 'anchor' mode of action to exert its biologic roles. [review]
      Title: STYX: a versatile pseudophosphatase.
    5. results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration
      Title: Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Identification of potentially damaging amino acid substitutions leading to human male infertility.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42934

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables F-box domain binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pseudophosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine/tyrosine-interacting protein
    Names
    inactive tyrosine-protein phosphatase STYX
    phosphoserine/threonine/tyrosine interaction protein
    protein tyrosine phosphatase-like protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030377.1 RefSeqGene

      Range
      5002..49825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130701.2 → NP_001124173.1  serine/threonine/tyrosine-interacting protein

      See identical proteins and their annotated locations for NP_001124173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses different splice sites in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL139317, AL832591, BQ772275, DB498442
      Consensus CDS
      CCDS9711.1
      UniProtKB/Swiss-Prot
      B9EJG0, Q8WUJ0, Q99850
      Related
      ENSP00000403214.2, ENST00000442123.6
      Conserved Domains (1) summary
      cd14522
      Location:25 → 175
      DSP_STYX; dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein

    2. NM_145251.4 → NP_660294.1  serine/threonine/tyrosine-interacting protein

      See identical proteins and their annotated locations for NP_660294.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the more frequently occurring transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK098195, AL139317, BC020265, BQ772275, DB498442
      Consensus CDS
      CCDS9711.1
      UniProtKB/Swiss-Prot
      B9EJG0, Q8WUJ0, Q99850
      Related
      ENSP00000346599.4, ENST00000354586.5
      Conserved Domains (1) summary
      cd14522
      Location:25 → 175
      DSP_STYX; dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      52730166..52774989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537108.2 → XP_011535410.1  serine/threonine/tyrosine-interacting protein isoform X1

      Conserved Domains (1) summary
      cd00127
      Location:4 → 147
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    2. XM_047431731.1 → XP_047287687.1  serine/threonine/tyrosine-interacting protein isoform X2

    3. XM_011537109.3 → XP_011535411.1  serine/threonine/tyrosine-interacting protein isoform X3

      Conserved Domains (1) summary
      cl21483
      Location:2 → 60
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      46937959..46982783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376650.1 → XP_054232625.1  serine/threonine/tyrosine-interacting protein isoform X1

    2. XM_054376651.1 → XP_054232626.1  serine/threonine/tyrosine-interacting protein isoform X2

    3. XM_054376652.1 → XP_054232627.1  serine/threonine/tyrosine-interacting protein isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WUJ0.1 GenPept UniProtKB/Swiss-Prot:Q8WUJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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