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    hmx3a H6 family homeobox 3a [ Danio rerio (zebrafish) ]

    Gene ID: 60310, updated on 28-Oct-2024

    Summary

    Official Symbol
    hmx3aprovided by ZNC
    Official Full Name
    H6 family homeobox 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001020-1
    See related
    Ensembl:ENSDARG00000070955 AllianceGenome:ZFIN:ZDB-GENE-001020-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hmx3; Nkx5-1; nkx5.1; zgc:109845
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within inner ear development; posterior lateral line neuromast primordium migration; and spinal cord development. Predicted to be active in nucleus. Is expressed in several structures, including dorsolateral placode; nervous system; neural tube; neuroblast (sensu Vertebrata); and otic vesicle. Orthologous to human HMX3 (H6 family homeobox 3). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See hmx3a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (21790606..21793050, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (21770770..21773274, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488094 Neighboring gene G protein-coupled receptor 26 Neighboring gene H6 family homeobox 2 Neighboring gene IKAROS family zinc finger 5 Neighboring gene interferon induced protein 44e

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homeobox protein HMX3
    Names
    H6 family homeobox 3
    homeo box (H6 family) 3
    homeobox protein H6 family member 3
    homeobox protein Nkx-5.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131634.2NP_571709.2  homeobox protein HMX3

      Status: VALIDATED

      Source sequence(s)
      AL773596, EH585322
      UniProtKB/Swiss-Prot
      A9Y2A8, Q504H8, Q9DFB1
      UniProtKB/TrEMBL
      A0A8N7UZL9, F1QMB1
      Related
      ENSDARP00000095383.4, ENSDART00000104612.5
      Conserved Domains (1) summary
      pfam00046
      Location:173226
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      21790606..21793050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158695.5XP_005158752.1  homeobox protein HMX3 isoform X1

      UniProtKB/Swiss-Prot
      A9Y2A8, Q504H8, Q9DFB1
      UniProtKB/TrEMBL
      A0A8M2B544
      Conserved Domains (1) summary
      pfam00046
      Location:172225
      Homeobox; Homeobox domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394986.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      38140..40584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)