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    IGF2 insulin like growth factor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710802, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IGF2provided by VGNC
    Official Full Name
    insulin like growth factor 2provided by VGNC
    Primary source
    VGNC:VGNC:101281
    See related
    Ensembl:ENSMMUG00000047449
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IGF2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (2192527..2219265, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (1954752..1981645, complement)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-675 Neighboring gene H19, imprinted maternally expressed transcript (non-protein coding) Neighboring gene uncharacterized LOC114672210 Neighboring gene insulin Neighboring gene tyrosine hydroxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells. Mitalipov S, et al. Stem Cells, 2007 Mar. PMID 17170068
    2. IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey. Ghosh D, et al. Reproduction, 2011 Apr. PMID 21292726
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. abnormal hypermethylation within the IGF2/H19 IC in all analyzed embryonic stem cell lines lines
      Title: Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells.
    2. A functional network involving VEGF, IGF2, and MMP9 in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
      Title: IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      2192527..2219265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015113346.2 → XP_014968832.2  insulin-like growth factor II isoform X2

      UniProtKB/TrEMBL
      A0A5F8AD35
      Related
      ENSMMUP00000075297.1, ENSMMUT00000106459.1
      Conserved Domains (2) summary
      cd04368
      Location:92 → 155
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:176 → 230
      IGF2_C; Insulin-like growth factor II E-peptide

    2. XM_028833047.1 → XP_028688880.1  insulin-like growth factor II isoform X1

      Conserved Domains (2) summary
      cd04368
      Location:92 → 158
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:179 → 233
      IGF2_C; Insulin-like growth factor II E-peptide

    3. XM_015113350.2 → XP_014968836.2  insulin-like growth factor II isoform X5

      UniProtKB/TrEMBL
      A0A1D5R7J7, G7NBL8
      Conserved Domains (2) summary
      cd04368
      Location:28 → 91
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:112 → 166
      IGF2_C; Insulin-like growth factor II E-peptide

    4. XM_015113347.2 → XP_014968833.2  insulin-like growth factor II isoform X3

      Conserved Domains (3) summary
      cd04368
      Location:84 → 150
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:171 → 225
      IGF2_C; Insulin-like growth factor II E-peptide
      cl00015
      Location:4 → 51
      nt_trans; nucleotidyl transferase superfamily

    5. XM_015113349.2 → XP_014968835.2  insulin-like growth factor II isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZM98, G7NBL8
      Related
      ENSMMUP00000065740.1, ENSMMUT00000080772.1
      Conserved Domains (3) summary
      cd04368
      Location:84 → 147
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:168 → 222
      IGF2_C; Insulin-like growth factor II E-peptide
      cl00015
      Location:4 → 51
      nt_trans; nucleotidyl transferase superfamily

    6. XM_028833048.1 → XP_028688881.1  insulin-like growth factor II isoform X5

      UniProtKB/TrEMBL
      A0A1D5R7J7, G7NBL8
      Conserved Domains (2) summary
      cd04368
      Location:28 → 91
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:112 → 166
      IGF2_C; Insulin-like growth factor II E-peptide

    7. XM_015113351.2 → XP_014968837.2  insulin-like growth factor II isoform X5

      UniProtKB/TrEMBL
      A0A1D5R7J7, G7NBL8
      Related
      ENSMMUP00000056286.2, ENSMMUT00000075671.2
      Conserved Domains (2) summary
      cd04368
      Location:28 → 91
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:112 → 166
      IGF2_C; Insulin-like growth factor II E-peptide

    8. XM_015113352.2 → XP_014968838.2  insulin-like growth factor II isoform X5

      UniProtKB/TrEMBL
      A0A1D5R7J7, G7NBL8
      Conserved Domains (2) summary
      cd04368
      Location:28 → 91
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:112 → 166
      IGF2_C; Insulin-like growth factor II E-peptide

    9. XM_015113353.2 → XP_014968839.2  insulin-like growth factor II isoform X5

      UniProtKB/TrEMBL
      A0A1D5R7J7, G7NBL8
      Conserved Domains (2) summary
      cd04368
      Location:28 → 91
      IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
      pfam08365
      Location:112 → 166
      IGF2_C; Insulin-like growth factor II E-peptide
    Nucleotide Protein
    Heading Accession and Version

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