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    elavl3 ELAV like neuron-specific RNA binding protein 3 [ Danio rerio (zebrafish) ]

    Gene ID: 30732, updated on 2-Nov-2024

    Summary

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    Official Symbol
    elavl3provided by ZNC
    Official Full Name
    ELAV like neuron-specific RNA binding protein 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-76
    See related
    Ensembl:ENSDARG00000014420 AllianceGenome:ZFIN:ZDB-GENE-980526-76
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    HuC; elrc; zHuC; id:ibd1248; wu:fb77b03
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within regulation of neurogenesis. Predicted to be part of ribonucleoprotein complex. Is expressed in several structures, including nervous system; neural plate; neural tube; neuronal stem cell; and presumptive structure. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See elavl3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (46801258..46817868, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (48847856..48865537, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:dkey-248g21.1 Neighboring gene phosphodiesterase 4A, cAMP-specific Neighboring gene PRKCSH beta subunit of glucosidase II Neighboring gene uncharacterized LOC103910324 Neighboring gene potassium sodium-activated channel subfamily T member 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. All-optical imaging and manipulation of whole-brain neuronal activities in behaving larval zebrafish. Jiao ZF, et al. Biomed Opt Express, 2018 Dec 1. PMID 31065420, Free PMC Article
    2. PyZebrascope: An Open-Source Platform for Brain-Wide Neural Activity Imaging in Zebrafish. Barbara R, et al. Front Cell Dev Biol, 2022. PMID 35663407, Free PMC Article
    3. Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons. Won YJ, et al. J Neurophysiol, 2011 Jan. PMID 20962070, Free PMC Article
    4. Prolonged, brain-wide expression of nuclear-localized GCaMP3 for functional circuit mapping. Kim CK, et al. Front Neural Circuits, 2014. PMID 25505384, Free PMC Article
    5. Differential impact of dose-range glyphosate on locomotor behavior, neuronal activity, glio-cerebrovascular structures, and transcript regulations in zebrafish larvae. Forner-Piquer I, et al. Chemosphere, 2021 Mar. PMID 33359984

    See all (346) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ELAV-like protein 3
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
    elav-related C
    elavC
    embryonic lethal, abnormal vision-related C
    etID309927.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131449.1 → NP_571524.1  ELAV-like protein 3

      See identical proteins and their annotated locations for NP_571524.1

      Status: PROVISIONAL

      Source sequence(s)
      U62018
      UniProtKB/TrEMBL
      P79736
      Related
      ENSDARP00000012109.7, ENSDART00000013717.9
      Conserved Domains (3) summary
      cd12650
      Location:37 → 114
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      TIGR01661
      Location:35 → 344
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:261 → 345
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      46801258..46817868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164219.5 → XP_005164276.1  ELAV-like protein 3 isoform X3

      See identical proteins and their annotated locations for XP_005164276.1

      UniProtKB/TrEMBL
      A0A8M2BBG3, Q6P105
      Related
      ENSDARP00000030680.6, ENSDART00000028610.8
      Conserved Domains (1) summary
      TIGR01661
      Location:35 → 358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. XM_017353190.3 → XP_017208679.1  ELAV-like protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8M6Z446

    3. XM_005164220.5 → XP_005164277.1  ELAV-like protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0R4IC33, A0A8M2BBP9
      Related
      ENSDARP00000130425.2, ENSDART00000166505.3
      Conserved Domains (1) summary
      TIGR01661
      Location:35 → 357
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    4. XM_005164218.5 → XP_005164275.1  ELAV-like protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BBS5
      Conserved Domains (4) summary
      cd12650
      Location:37 → 114
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12655
      Location:281 → 365
      RRM3_HuC; RNA recognition motif 3 in vertebrate Hu-antigen C (HuC)
      TIGR01661
      Location:35 → 364
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:119 → 208
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_017353191.3 → XP_017208680.1  ELAV-like protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8M6YUY6
      Conserved Domains (1) summary
      cl25887
      Location:35 → 345
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    6. XM_017353188.3 → XP_017208677.1  ELAV-like protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M6YXB4

    7. XM_009299733.4 → XP_009298008.1  ELAV-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AYA7
      Conserved Domains (4) summary
      cd12650
      Location:37 → 114
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12655
      Location:282 → 366
      RRM3_HuC; RNA recognition motif 3 in vertebrate Hu-antigen C (HuC)
      TIGR01661
      Location:35 → 365
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:119 → 209
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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