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    mhc2a major histocompatibility complex class II integral membrane alpha chain gene [ Danio rerio (zebrafish) ]

    Gene ID: 30783, updated on 17-Aug-2024

    Summary

    Official Symbol
    mhc2aprovided by ZNC
    Official Full Name
    major histocompatibility complex class II integral membrane alpha chain geneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    a4
    Annotation information
    not in current annotation release
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    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    major histocompatibility complex class II integral membrane alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131490.1NP_571565.1  major histocompatibility complex class II integral membrane alpha chain precursor

      See identical proteins and their annotated locations for NP_571565.1

      Status: PROVISIONAL

      Source sequence(s)
      L19451
      UniProtKB/TrEMBL
      Q31362
      Conserved Domains (2) summary
      pfam00993
      Location:30107
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cl11960
      Location:111204
      Ig; Immunoglobulin domain