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    sod-4 Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn] [ Caenorhabditis elegans ]

    Gene ID: 176336, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sod-4
    Official Full Name
    Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]
    Primary source
    WormBase:WBGene00004933
    Locus tag
    CELE_F55H2.1
    See related
    AllianceGenome:WB:WBGene00004933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables superoxide dismutase activity. Involved in superoxide metabolic process. Located in extracellular space and membrane. Is expressed in intestine; nervous system; rectal gland cell; and somatic gonad. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sod-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (9497019..9500202, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Beta-1,4-mannosyltransferase bre-3 Neighboring gene Neuropeptide-like peptide 36 Neighboring gene Aspartate--tRNA ligase, cytoplasmic Neighboring gene RNA polymerase-associated protein CTR9 Neighboring gene pseudo Neighboring gene V-type proton ATPase subunit D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toxicity of Three Optical Brighteners: Potential Pharmacological Targets and Effects on Caenorhabditis elegans. Castro-Sierra I, et al. Toxics, 2024 Jan 9. PMID 38251007, Free PMC Article
    2. Bioprocessing in microgravity: free flow electrophoresis of C. elegans DNA. Kobayashi H, et al. J Biotechnol, 1996 Jun 27. PMID 8987575
    3. Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Doonan R, et al. Genes Dev, 2008 Dec 1. PMID 19056880, Free PMC Article
    4. Pollution by metals and toxicity assessment using Caenorhabditis elegans in sediments from the Magdalena River, Colombia. Tejeda-Benitez L, et al. Environ Pollut, 2016 May. PMID 26851980
    5. Toxicity of atrazine- and glyphosate-based formulations on Caenorhabditis elegans. García-Espiñeira M, et al. Ecotoxicol Environ Saf, 2018 Jul 30. PMID 29550685

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide dismutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in superoxide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]
    NP_001255002.1
    • Confirmed by transcript evidence
    NP_001255003.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9497019..9500202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268073.4 → NP_001255002.1  Superoxide dismutase [Cu-Zn] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61260, P34461
      UniProtKB/TrEMBL
      G5ECR5
      Conserved Domains (1) summary
      cd00305
      Location:41 → 170
      Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...

    2. NM_001268074.5 → NP_001255003.1  Extracellular superoxide dismutase [Cu-Zn] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255003.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34461
      Conserved Domains (1) summary
      cd00305
      Location:41 → 170
      Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
    Nucleotide Protein
    Heading Accession and Version

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