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    PLA2G15 phospholipase A2 group XV [ Homo sapiens (human) ]

    Gene ID: 23659, updated on 14-Nov-2024

    Summary

    Official Symbol
    PLA2G15provided by HGNC
    Official Full Name
    phospholipase A2 group XVprovided by HGNC
    Primary source
    HGNC:HGNC:17163
    See related
    Ensembl:ENSG00000103066 MIM:609362; AllianceGenome:HGNC:17163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACS; LLPL; LPLA2; LYPLA3; GXVPLA2
    Summary
    Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 17.1), heart (RPKM 11.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PLA2G15 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (68245373..68261058)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74041120..74056809)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68279276..68294961)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11007 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68270229-68270817 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68270818-68271405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68271406-68271994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68271995-68272581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68278082-68278620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68279742-68280242 Neighboring gene microRNA 6773 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene uncharacterized LOC124903704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7645 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:68298967-68300166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11009 Neighboring gene Sharpr-MPRA regulatory region 10574 Neighboring gene solute carrier family 7 member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11010 Neighboring gene RNA, U6 small nuclear 1262, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • DKFZp564A0122

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables O-acyltransferase activity  
    enables O-acyltransferase activity PubMed 
    enables O-acyltransferase activity  
    enables acylglycerol O-acyltransferase activity  
    enables calcium-dependent phospholipase A2 activity  
    enables calcium-independent phospholipase A2 activity  
    enables calcium-independent phospholipase A2 activity PubMed 
    enables calcium-independent phospholipase A2 activity  
    enables calcium-independent phospholipase A2 activity  
    enables lysophospholipase activity  
    enables phosphatidylserine 1-acylhydrolase activity  
    enables phospholipase A1 activity PubMed 
    enables phospholipase A1 activity  
    enables phospholipid binding PubMed 
    enables protein binding PubMed 
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in intracellular membrane-bounded organelle  
    is_active_in lysosome  
    located_in lysosome  
    located_in lysosome PubMed 
    located_in membrane  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    lysosomal phospholipase A and acyltransferase
    Names
    1-O-acylceramide synthase
    LCAT-like lysophospholipase
    group XV phospholipase A2
    lysophospholipase 3 (lysosomal phospholipase A2)
    lysosomal phospholipase A2
    NP_001350480.1
    NP_036452.1
    XP_011521281.1
    XP_011521282.3
    XP_047289843.1
    XP_054235960.1
    XP_054235961.1
    XP_054235962.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363551.2NP_001350480.1  lysosomal phospholipase A and acyltransferase isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC020978, AK296263
      Consensus CDS
      CCDS92182.1
      UniProtKB/TrEMBL
      B4DJW4, H3BPT3
      Related
      ENSP00000457034.1, ENST00000566188.5
      Conserved Domains (1) summary
      cl21494
      Location:74167
      Abhydrolase; alpha/beta hydrolases
    2. NM_012320.4NP_036452.1  lysosomal phospholipase A and acyltransferase isoform 1 precursor

      See identical proteins and their annotated locations for NP_036452.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK074828, BC062605
      Consensus CDS
      CCDS10864.1
      UniProtKB/Swiss-Prot
      B3KMF3, B4DUD1, Q53GZ1, Q8NCC3, Q9NPQ6, Q9UG04, Q9Y2B3
      Related
      ENSP00000219345.5, ENST00000219345.10
      Conserved Domains (1) summary
      cl21494
      Location:74396
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      68245373..68261058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522979.3XP_011521281.1  lysosomal phospholipase A and acyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011521281.1

      Conserved Domains (1) summary
      cl21494
      Location:74428
      Abhydrolase; alpha/beta hydrolases
    2. XM_011522980.4XP_011521282.3  lysosomal phospholipase A and acyltransferase isoform X2

      Related
      ENSP00000455461.2, ENST00000564827.6
    3. XM_047433887.1XP_047289843.1  lysosomal phospholipase A and acyltransferase isoform X3

      Related
      ENSP00000394197.2, ENST00000413021.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      74041120..74056809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379985.1XP_054235960.1  lysosomal phospholipase A and acyltransferase isoform X1

    2. XM_054379986.1XP_054235961.1  lysosomal phospholipase A and acyltransferase isoform X2

    3. XM_054379987.1XP_054235962.1  lysosomal phospholipase A and acyltransferase isoform X3

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