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    ZNF358 zinc finger protein 358 [ Homo sapiens (human) ]

    Gene ID: 140467, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF358provided by HGNC
    Official Full Name
    zinc finger protein 358provided by HGNC
    Primary source
    HGNC:HGNC:16838
    See related
    Ensembl:ENSG00000198816 MIM:619496; AllianceGenome:HGNC:16838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFEND
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic forelimb morphogenesis; neural tube development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 21.7), ovary (RPKM 18.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF358 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7513880..7521025)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7514603..7521761)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7580989..7585911)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7541732-7542367 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7548591-7549112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9983 Neighboring gene Sharpr-MPRA regulatory region 6634 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9984 Neighboring gene Sharpr-MPRA regulatory region 11228 Neighboring gene uncharacterized LOC105372261 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9985 Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13887 Neighboring gene mucolipin TRP cation channel 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7614843-7615534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7615535-7616226 Neighboring gene patatin like phospholipase domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization and in silico mapping of a novel murine zinc finger transcription factor. Wride MA, et al. Gene, 2002 May 1. PMID 12036583
    2. Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV. Bassi MT, et al. Am J Hum Genet, 2000 Nov. PMID 11013137, Free PMC Article
    3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
    4. The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis. Vaughan N, et al. Sci Rep, 2022 Aug 1. PMID 35915203, Free PMC Article
    5. EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation. Wang L, et al. Nat Commun, 2022 Jan 10. PMID 35013218, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10390

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic forelimb morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neural tube development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 358

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018083.5 → NP_060553.4  zinc finger protein 358

      See identical proteins and their annotated locations for NP_060553.4

      Status: VALIDATED

      Source sequence(s)
      AC008878, AK001252, BC003585, BI601846
      Consensus CDS
      CCDS32890.2
      UniProtKB/Swiss-Prot
      Q9BTM7, Q9NW07
      Related
      ENSP00000472305.1, ENST00000597229.2
      Conserved Domains (6) summary
      cd11674
      Location:108 → 174
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:35 → 339
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:166 → 190
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:292 → 370
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      7513880..7521025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438181.1 → XP_047294137.1  zinc finger protein 358 isoform X1

    2. XM_005272460.4 → XP_005272517.1  zinc finger protein 358 isoform X2

      See identical proteins and their annotated locations for XP_005272517.1

      UniProtKB/Swiss-Prot
      Q9BTM7, Q9NW07
      Conserved Domains (6) summary
      cd11674
      Location:108 → 174
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:35 → 339
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:166 → 190
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:292 → 370
      zf-C2H2_8; C2H2-type zinc ribbon

    3. XM_011527695.1 → XP_011525997.1  zinc finger protein 358 isoform X2

      See identical proteins and their annotated locations for XP_011525997.1

      UniProtKB/Swiss-Prot
      Q9BTM7, Q9NW07
      Conserved Domains (6) summary
      cd11674
      Location:108 → 174
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:35 → 339
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:166 → 190
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:292 → 370
      zf-C2H2_8; C2H2-type zinc ribbon

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      7514603..7521761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319835.1 → XP_054175810.1  zinc finger protein 358 isoform X1

    2. XM_054319836.1 → XP_054175811.1  zinc finger protein 358 isoform X2

      UniProtKB/Swiss-Prot
      Q9BTM7, Q9NW07

    3. XM_054319837.1 → XP_054175812.1  zinc finger protein 358 isoform X2

      UniProtKB/Swiss-Prot
      Q9BTM7, Q9NW07
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NW07.2 GenPept UniProtKB/Swiss-Prot:Q9NW07

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