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    Smtnl2 smoothelin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 276829, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Smtnl2provided by MGI
    Official Full Name
    smoothelin-like 2provided by MGI
    Primary source
    MGI:MGI:2442764
    See related
    Ensembl:ENSMUSG00000045667 AllianceGenome:MGI:2442764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130058I21Rik
    Summary
    Predicted to be involved in actin cytoskeleton organization. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in several structures, including adipose tissue; femur; heart; lung; and metanephros. Orthologous to human SMTNL2 (smoothelin like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 9.3), mammary gland adult (RPKM 6.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Smtnl2 in Genome Data Viewer
    Location:
    11 B4; 11 44.15 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72279989..72302539, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72389163..72411713, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tektin 1 Neighboring gene predicted gene, 34317 Neighboring gene microRNA 6338 Neighboring gene STARR-seq mESC enhancer starr_29906 Neighboring gene STARR-positive B cell enhancer ABC_E10683 Neighboring gene STARR-positive B cell enhancer ABC_E8422 Neighboring gene gamma-glutamyltransferase 6 Neighboring gene MYB binding protein (P160) 1a Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cells. Wu D, et al. Mol Cell Endocrinol, 2022 Jul 1. PMID 35551947
    2. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595
    3. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. Goldbraikh D, et al. EMBO Rep, 2020 Apr 3. PMID 32133736, Free PMC Article
    4. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato M, et al. Mech Dev, 2004 Jun. PMID 15172686
    5. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cells.
      Title: Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47155

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of filamentous actin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    smoothelin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177776.3 → NP_808444.1  smoothelin-like protein 2

      See identical proteins and their annotated locations for NP_808444.1

      Status: PROVISIONAL

      Source sequence(s)
      AL662812
      Consensus CDS
      CCDS24985.1
      UniProtKB/Swiss-Prot
      Q8CI12
      UniProtKB/TrEMBL
      Q5F247
      Related
      ENSMUSP00000059043.7, ENSMUST00000050226.7
      Conserved Domains (2) summary
      cd00014
      Location:349 → 453
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl01090
      Location:56 → 89
      SlyX; SlyX

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72279989..72302539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156740.1 → XP_036012633.1  smoothelin-like protein 2 isoform X1

      Conserved Domains (1) summary
      cd21261
      Location:244 → 350
      CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2

    2. XM_036156742.1 → XP_036012635.1  smoothelin-like protein 2 isoform X4

      Conserved Domains (1) summary
      cd21261
      Location:226 → 332
      CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2

    3. XM_006533470.3 → XP_006533533.1  smoothelin-like protein 2 isoform X5

      Conserved Domains (1) summary
      pfam00307
      Location:220 → 325
      CH; Calponin homology (CH) domain

    4. XM_036156743.1 → XP_036012636.1  smoothelin-like protein 2 isoform X6

      Conserved Domains (1) summary
      cd21261
      Location:160 → 266
      CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2

    5. XM_036156741.1 → XP_036012634.1  smoothelin-like protein 2 isoform X3

      Conserved Domains (1) summary
      cd21261
      Location:230 → 336
      CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2

    6. XM_006533469.4 → XP_006533532.1  smoothelin-like protein 2 isoform X2

      Conserved Domains (1) summary
      pfam00307
      Location:243 → 348
      CH; Calponin homology (CH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI12.1 GenPept UniProtKB/Swiss-Prot:Q8CI12

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