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    ZSCAN25 zinc finger and SCAN domain containing 25 [ Homo sapiens (human) ]

    Gene ID: 221785, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZSCAN25provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 25provided by HGNC
    Primary source
    HGNC:HGNC:21961
    See related
    Ensembl:ENSG00000197037 AllianceGenome:HGNC:21961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF498
    Summary
    This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in small intestine (RPKM 5.1), duodenum (RPKM 3.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99616946..99738035)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100851926..100993657)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99214569..99270165)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26326 Neighboring gene zinc finger protein 655 Neighboring gene transmembrane protein 225B Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99213715-99214694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99227460-99228106 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99236540-99236705 Neighboring gene ADP ribosylation factor 6 pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 5 Neighboring gene CYP3A7-CYP3A51P readthrough Neighboring gene CYP3A5 promoter Neighboring gene cytochrome P450 family 3 subfamily A member 51, pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene CYP3A7 5' regulatory region Neighboring gene enhancer in intron 10 of CYP3A4 Neighboring gene cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 Neighboring gene cytochrome P450 family 3 subfamily A member 4 Neighboring gene CYP3A4 5' regulatory region

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation. Zhang X, et al. J Exp Clin Cancer Res, 2022 Feb 28. PMID 35227287, Free PMC Article
    2. Sequence diversity and haplotype structure at the human CYP3A cluster. Thompson EE, et al. Pharmacogenomics J, 2006 Mar-Apr. PMID 16314882
    3. Zinc finger proteins: new insights into structural and functional diversity. Laity JH, et al. Curr Opin Struct Biol, 2001 Feb. PMID 11179890
    4. NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA. Wei X, et al. PLoS Pathog, 2019 Nov. PMID 31751430, Free PMC Article
    5. An atlas of genetic influences on human blood metabolites. Shin SY, et al. Nat Genet, 2014 Jun. PMID 24816252, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome.
      Title: ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome.
    2. ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation.
      Title: ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 25
    Names
    zinc finger protein 498

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001350979.2 → NP_001337908.1  zinc finger and SCAN domain-containing protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longest isoform (a).
      Source sequence(s)
      AC005020
      Consensus CDS
      CCDS5671.2
      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
      Related
      ENSP00000334800.3, ENST00000334715.7
      Conserved Domains (4) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:324 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:38 → 136
      SCAN; SCAN oligomerization domain

    2. NM_001350980.2 → NP_001337909.1  zinc finger and SCAN domain-containing protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes the longest isoform (a).
      Source sequence(s)
      AC005020
      Consensus CDS
      CCDS5671.2
      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
      Conserved Domains (4) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:324 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:38 → 136
      SCAN; SCAN oligomerization domain

    3. NM_001350981.2 → NP_001337910.1  zinc finger and SCAN domain-containing protein 25 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform b.
      Source sequence(s)
      AC005020
      UniProtKB/TrEMBL
      B3KPY4
      Conserved Domains (4) summary
      cd07765
      Location:67 → 95
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:160 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:336 → 361
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001350982.2 → NP_001337911.1  zinc finger and SCAN domain-containing protein 25 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform b.
      Source sequence(s)
      AC005020
      UniProtKB/TrEMBL
      B3KPY4
      Conserved Domains (4) summary
      cd07765
      Location:67 → 95
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:160 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:336 → 361
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001350983.2 → NP_001337912.1  zinc finger and SCAN domain-containing protein 25 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform b.
      Source sequence(s)
      AC005020
      UniProtKB/TrEMBL
      B3KPY4
      Conserved Domains (4) summary
      cd07765
      Location:67 → 95
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:160 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:336 → 361
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001350984.2 → NP_001337913.1  zinc finger and SCAN domain-containing protein 25 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 8, represents the longest transcript and encodes isoform c.
      Source sequence(s)
      AC005020
      Conserved Domains (2) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      pfam02023
      Location:38 → 123
      SCAN; SCAN domain

    7. NM_001350985.2 → NP_001337914.1  zinc finger and SCAN domain-containing protein 25 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform c.
      Source sequence(s)
      AC005020
      Conserved Domains (2) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      pfam02023
      Location:38 → 123
      SCAN; SCAN domain

    8. NM_001350986.2 → NP_001337915.1  zinc finger and SCAN domain-containing protein 25 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC005020
      Conserved Domains (1) summary
      pfam02023
      Location:38 → 123
      SCAN; SCAN domain

    9. NM_145115.3 → NP_660090.2  zinc finger and SCAN domain-containing protein 25 isoform a

      See identical proteins and their annotated locations for NP_660090.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2 and 3, encodes the longest isoform (a).
      Source sequence(s)
      AC005020, AW195325, BX648158
      Consensus CDS
      CCDS5671.2
      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
      Related
      ENSP00000377708.2, ENST00000394152.7
      Conserved Domains (4) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:324 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:38 → 136
      SCAN; SCAN oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      99616946..99738035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420018.1 → XP_047275974.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    2. XM_047420016.1 → XP_047275972.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    3. XM_011515909.3 → XP_011514211.1  zinc finger and SCAN domain-containing protein 25 isoform X2

      Conserved Domains (2) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      pfam02023
      Location:38 → 123
      SCAN; SCAN domain

    4. XM_047420019.1 → XP_047275975.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    5. XM_047420017.1 → XP_047275973.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    6. XM_011515910.3 → XP_011514212.1  zinc finger and SCAN domain-containing protein 25 isoform X3

      Conserved Domains (2) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      pfam02023
      Location:38 → 123
      SCAN; SCAN domain

    7. XM_047420020.1 → XP_047275976.1  zinc finger and SCAN domain-containing protein 25 isoform X3

    8. XM_047420011.1 → XP_047275967.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    9. XM_047420014.1 → XP_047275970.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    10. XM_011515907.3 → XP_011514209.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011514209.1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
      Conserved Domains (4) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:324 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:38 → 136
      SCAN; SCAN oligomerization domain

    11. XM_047420013.1 → XP_047275969.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    12. XM_047420015.1 → XP_047275971.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    13. XM_011515905.3 → XP_011514207.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011514207.1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3
      Conserved Domains (4) summary
      cd07765
      Location:231 → 259
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:324 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:38 → 136
      SCAN; SCAN oligomerization domain

    14. XM_047420012.1 → XP_047275968.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    RNA

    1. XR_927402.3 RNA Sequence

    2. XR_007059989.1 RNA Sequence

    3. XR_007059990.1 RNA Sequence

    4. XR_007059988.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      100851926..100993657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357521.1 → XP_054213496.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    2. XM_054357525.1 → XP_054213500.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    3. XM_054357524.1 → XP_054213499.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    4. XM_054357529.1 → XP_054213504.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    5. XM_054357526.1 → XP_054213501.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    6. XM_054357527.1 → XP_054213502.1  zinc finger and SCAN domain-containing protein 25 isoform X3

    7. XM_054357530.1 → XP_054213505.1  zinc finger and SCAN domain-containing protein 25 isoform X3

    8. XM_054357522.1 → XP_054213497.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    9. XM_054357518.1 → XP_054213493.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    10. XM_054357520.1 → XP_054213495.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    11. XM_054357523.1 → XP_054213498.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    12. XM_054357517.1 → XP_054213492.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    13. XM_054357519.1 → XP_054213494.1  zinc finger and SCAN domain-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      A4D290, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6NSZ9, Q6ZML3

    14. XM_054357528.1 → XP_054213503.1  zinc finger and SCAN domain-containing protein 25 isoform X2

    RNA

    1. XR_008487539.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NSZ9.3 GenPept UniProtKB/Swiss-Prot:Q6NSZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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