RBPMS RNA binding protein, mRNA processing factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBPMSprovided by HGNC
Official Full Name: RNA binding protein, mRNA processing factorprovided by HGNC
Primary source: HGNC:HGNC:19097
See related: Ensembl:ENSG00000157110 MIM:601558; AllianceGenome:HGNC:19097
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HERMES
Summary: This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Expression: Ubiquitous expression in prostate (RPKM 14.5), ovary (RPKM 13.7) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (30384541..30572256)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (30663428..30851701)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (30242057..30429773)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.
Title: RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.
Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators.
Title: Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators.
SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation.
Title: SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation.
mRNA translational specialization by RBPMS presets the competence for cardiac commitment in hESCs.
Title: mRNA translational specialization by RBPMS presets the competence for cardiac commitment in hESCs.
Increased Expression of the RBPMS Splice Variants Inhibits Cell Proliferation in Ovarian Cancer Cells.
Title: Increased Expression of the RBPMS Splice Variants Inhibits Cell Proliferation in Ovarian Cancer Cells.
Loss of RBPMS in ovarian cancer compromises the efficacy of EGFR inhibitor gefitinib through activating HER2/AKT/mTOR/P70S6K signaling.
Title: Loss of RBPMS in ovarian cancer compromises the efficacy of EGFR inhibitor gefitinib through activating HER2/AKT/mTOR/P70S6K signaling.
Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells.
Title: Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells.
the key role of miR-21-3p in CRC
Title: Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal cancer HCT116 cells.
RBPMS silencing confers resistance to MM cells.
Title: Dysregulation of EZH2/miR-138 axis contributes to drug resistance in multiple myeloma by downregulating RBPMS.
The possible involvement of the GC box 1 at position - 54 in transcriptional regulation of Rbpms was corroborated by EMSA, which showed formation of a DNA-protein complex in the presence of the oligonucleotide corresponding to this Sp1-binding site.
Title: RNA-binding protein Rbpms is represented in human retinas by isoforms A and C and its transcriptional regulation involves Sp1-binding site.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rbpms (e-PCR), detects polymorphism
- UniSTS:479243

D8S2279 (e-PCR)
- UniSTS:473907

G32178 (e-PCR)
- UniSTS:43572

RH45543 (e-PCR)
- UniSTS:63305

D8S2215 (e-PCR)
- UniSTS:473933

SHGC-30104 (e-PCR)
- UniSTS:82786

SHGC-34085 (e-PCR)
- UniSTS:36201

D8S1445 (e-PCR)
- UniSTS:151728

D8S339 (e-PCR), detects polymorphism
- UniSTS:147929

RH68904 (e-PCR)
- UniSTS:5884

RH103464 (e-PCR)
- UniSTS:97789

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA CDS binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA intronic binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA processing	TAS Traceable Author Statement more info	PubMed
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA-binding protein with multiple splicing

Names: RNA binding protein with multiple splicing; heart and RRM expressed sequence

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029534.2 RefSeqGene

Range

5002..192717

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001008710.3 → NP_001008710.1 RNA-binding protein with multiple splicing isoform A

See identical proteins and their annotated locations for NP_001008710.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform A. Variants 1 and 4 encode the same isoform.

Source sequence(s)

BC003608, BX097929, CN360712, CX165198, CX781149, D84107

Consensus CDS

CCDS6077.1

UniProtKB/Swiss-Prot

D3DSU9, Q92516, Q92517, Q92518, Q93062, Q96J26

UniProtKB/TrEMBL

Q569H2

Related

ENSP00000380486.4, ENST00000397323.9

Conserved Domains (2) summary

TIGR01628
Location:64 → 165

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
NM_001008711.3 → NP_001008711.1 RNA-binding protein with multiple splicing isoform B

See identical proteins and their annotated locations for NP_001008711.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (B) has a longer and distinct C-terminus, compared to isoform A.

Source sequence(s)

BC003608, BX097929, CN360712, CX165198, CX781149, D84108

Consensus CDS

CCDS34875.1

UniProtKB/TrEMBL

Q569H2

Related

ENSP00000287771.5, ENST00000287771.9

Conserved Domains (2) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

cl25887
Location:26 → 200

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
NM_001008712.3 → NP_001008712.1 RNA-binding protein with multiple splicing isoform C

See identical proteins and their annotated locations for NP_001008712.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (C) has a longer and distinct C-terminus, compared to isoform A.

Source sequence(s)

AI025136, BC003608, CX165198

Consensus CDS

CCDS34876.1

UniProtKB/TrEMBL

Q569H2

Related

ENSP00000340176.4, ENST00000339877.8

Conserved Domains (2) summary

TIGR01628
Location:64 → 187

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
NM_006867.4 → NP_006858.1 RNA-binding protein with multiple splicing isoform A

See identical proteins and their annotated locations for NP_006858.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) includes an alternate exon in the 3' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (A).

Source sequence(s)

BC003608, BX097929, CA425568, CN360712, CX165198, CX781149, D84107

Consensus CDS

CCDS6077.1

UniProtKB/Swiss-Prot

D3DSU9, Q92516, Q92517, Q92518, Q93062, Q96J26

UniProtKB/TrEMBL

Q569H2

Related

ENSP00000318102.4, ENST00000320203.8

Conserved Domains (2) summary

TIGR01628
Location:64 → 165

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

30384541..30572256

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017012981.3 → XP_016868470.1 RNA-binding protein with multiple splicing isoform X3
XM_017012987.3 → XP_016868476.1 RNA-binding protein with multiple splicing isoform X8
XM_047421276.1 → XP_047277232.1 RNA-binding protein with multiple splicing isoform X2
XM_047421278.1 → XP_047277234.1 RNA-binding protein with multiple splicing isoform X12
XM_047421281.1 → XP_047277237.1 RNA-binding protein with multiple splicing isoform X18
XM_047421277.1 → XP_047277233.1 RNA-binding protein with multiple splicing isoform X10
XM_017012982.2 → XP_016868471.1 RNA-binding protein with multiple splicing isoform X4

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_017012980.3 → XP_016868469.1 RNA-binding protein with multiple splicing isoform X1
XM_017012990.3 → XP_016868479.1 RNA-binding protein with multiple splicing isoform X13
XM_024447054.2 → XP_024302822.1 RNA-binding protein with multiple splicing isoform X6

Conserved Domains (2) summary

cl17169
Location:14 → 40

RRM_SF; RNA recognition motif (RRM) superfamily

cl27087
Location:40 → 131

SPOR; Sporulation related domain
XM_017012989.3 → XP_016868478.1 RNA-binding protein with multiple splicing isoform X11

UniProtKB/TrEMBL

Q569H2

Conserved Domains (1) summary

cl17169
Location:23 → 98

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017012988.3 → XP_016868477.1 RNA-binding protein with multiple splicing isoform X9

UniProtKB/TrEMBL

Q569H2

Conserved Domains (2) summary

TIGR01628
Location:64 → 165

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cl17169
Location:23 → 98

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017012992.3 → XP_016868481.1 RNA-binding protein with multiple splicing isoform X17

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_047421279.1 → XP_047277235.1 RNA-binding protein with multiple splicing isoform X14
XM_017012984.2 → XP_016868473.1 RNA-binding protein with multiple splicing isoform X5

UniProtKB/TrEMBL

B4E3T4

Related

ENSP00000428675.1, ENST00000517860.5

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_017012985.3 → XP_016868474.1 RNA-binding protein with multiple splicing isoform X7
XM_047421280.1 → XP_047277236.1 RNA-binding protein with multiple splicing isoform X16
XM_024447055.2 → XP_024302823.1 RNA-binding protein with multiple splicing isoform X15

Conserved Domains (1) summary

cl17169
Location:5 → 38

RRM_SF; RNA recognition motif (RRM) superfamily

RNA

XR_007060693.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

30663428..30851701

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054359616.1 → XP_054215591.1 RNA-binding protein with multiple splicing isoform X3
XM_054359621.1 → XP_054215596.1 RNA-binding protein with multiple splicing isoform X8
XM_054359615.1 → XP_054215590.1 RNA-binding protein with multiple splicing isoform X2
XM_054359625.1 → XP_054215600.1 RNA-binding protein with multiple splicing isoform X12
XM_054359623.1 → XP_054215598.1 RNA-binding protein with multiple splicing isoform X10
XM_054359617.1 → XP_054215592.1 RNA-binding protein with multiple splicing isoform X4
XM_054359614.1 → XP_054215589.1 RNA-binding protein with multiple splicing isoform X1
XM_054359626.1 → XP_054215601.1 RNA-binding protein with multiple splicing isoform X13
XM_054359624.1 → XP_054215599.1 RNA-binding protein with multiple splicing isoform X11
XM_054359622.1 → XP_054215597.1 RNA-binding protein with multiple splicing isoform X9
XM_054359630.1 → XP_054215605.1 RNA-binding protein with multiple splicing isoform X17
XM_054359619.1 → XP_054215594.1 RNA-binding protein with multiple splicing isoform X5

UniProtKB/TrEMBL

B4E3T4
XM_054359618.1 → XP_054215593.1 RNA-binding protein with multiple splicing isoform X19
XM_054359627.1 → XP_054215602.1 RNA-binding protein with multiple splicing isoform X20
XM_054359628.1 → XP_054215603.1 RNA-binding protein with multiple splicing isoform X15
XM_054359620.1 → XP_054215595.1 RNA-binding protein with multiple splicing isoform X7
XM_054359629.1 → XP_054215604.1 RNA-binding protein with multiple splicing isoform X16