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    Armc8 armadillo repeat containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 74125, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Armc8provided by MGI
    Official Full Name
    armadillo repeat containing 8provided by MGI
    Primary source
    MGI:MGI:1921375
    See related
    Ensembl:ENSMUSG00000032468 AllianceGenome:MGI:1921375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gid5; HSPC056; 1200015K23Rik
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of GID complex. Orthologous to human ARMC8 (armadillo repeat containing 8). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.3), whole brain E14.5 (RPKM 9.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Armc8 in Genome Data Viewer
    Location:
    9 E3.3; 9 51.74 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99360438..99451471, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99478385..99568907, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene muscle and microspikes RAS Neighboring gene predicted gene, 53543 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene STARR-seq mESC enhancer starr_25026 Neighboring gene NME/NM23 family member 9 Neighboring gene STARR-positive B cell enhancer ABC_E6796 Neighboring gene debranching RNA lariats 1 Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteasome-dependent degradation of alpha-catenin is regulated by interaction with ARMc8alpha. Suzuki T, et al. Biochem J, 2008 May 1. PMID 18215130
    2. Loss of the tumor suppressor BAP1 causes myeloid transformation. Dey A, et al. Science, 2012 Sep 21. PMID 22878500, Free PMC Article
    3. Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Newton K, et al. Proc Natl Acad Sci U S A, 2018 Oct 30. PMID 30322923, Free PMC Article
    4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166138.1 → NP_001159610.1  armadillo repeat-containing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_001159610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK004793, AK078280, AK083094, BC038866
      Consensus CDS
      CCDS81059.1
      UniProtKB/Swiss-Prot
      Q9DBR3
      Related
      ENSMUSP00000139973.2, ENSMUST00000185524.7
      Conserved Domains (2) summary
      cd00020
      Location:57 → 172
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    2. NM_028768.3 → NP_083044.2  armadillo repeat-containing protein 8 isoform 1

      See identical proteins and their annotated locations for NP_083044.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC156497, AK004793
      Consensus CDS
      CCDS23434.1
      UniProtKB/Swiss-Prot
      Q8BGV2, Q8BUP3, Q9DBR3
      UniProtKB/TrEMBL
      G3X920
      Related
      ENSMUSP00000035043.6, ENSMUST00000035043.12
      Conserved Domains (3) summary
      cd00020
      Location:57 → 172
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00044
      Location:553 → 583
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      99360438..99451471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155355.1 → XP_036011248.1  armadillo repeat-containing protein 8 isoform X4

      UniProtKB/Swiss-Prot
      Q8BGV2, Q8BUP3, Q9DBR3
      Conserved Domains (4) summary
      COG5064
      Location:49 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:307 → 601
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:486 → 516
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    2. XM_006511515.5 → XP_006511578.1  armadillo repeat-containing protein 8 isoform X5

      UniProtKB/Swiss-Prot
      Q8BGV2, Q8BUP3, Q9DBR3
      Conserved Domains (3) summary
      COG5064
      Location:49 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:381 → 584
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    3. XM_006511513.5 → XP_006511576.1  armadillo repeat-containing protein 8 isoform X3

      UniProtKB/Swiss-Prot
      Q8BGV2, Q8BUP3, Q9DBR3
      Conserved Domains (3) summary
      COG5064
      Location:49 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:378 → 613
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    4. XM_006511511.5 → XP_006511574.1  armadillo repeat-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q8BGV2, Q8BUP3, Q9DBR3
      Conserved Domains (3) summary
      COG5064
      Location:49 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:374 → 539
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    5. XM_006511512.4 → XP_006511575.1  armadillo repeat-containing protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q8BGV2, Q8BUP3, Q9DBR3
      Conserved Domains (4) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:332 → 626
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:511 → 541
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBR3.2 GenPept UniProtKB/Swiss-Prot:Q9DBR3

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