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    dsx transcription factor doublesex [ Bombyx mori (domestic silkworm) ]

    Gene ID: 692415, updated on 12-Oct-2024

    Summary

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    Gene symbol
    dsx
    Gene description
    transcription factor doublesex
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bombyx mori
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
    Also known as
    dsx1; dsx2; dsx3; dsx4; dsx5; Bmdsx; dsxf1; dsxf2; dsxf3; dsxf4; dsxf5; dsxf6; dsxf7; dsxf8; dsxf9; dsxm1; dsxm2; dsxm3; dsxm4; dsxm5; dsxm6; dsxm7; dsxf10; dsx-dsr3; dsx-dsr4; dsx-dsr5; dsx-dsr7
    Orthologs
    fruit fly all
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    Genomic context

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    See dsx in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 25 NC_085131.1 (10593002..10796765, complement)
    103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 25 NC_051382.1 (10580656..10778265, complement)

    Chromosome 25 - NC_085131.1Genomic Context describing neighboring genes Neighboring gene homeobox protein prospero Neighboring gene uncharacterized LOC134201433 Neighboring gene Uxt prefoldin-like subunit Neighboring gene pickpocket protein 28 Neighboring gene NAD-dependent deacetylase sirtuin 2 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenic Expression of the piRNA-Resistant Masculinizer Gene Induces Female-Specific Lethality and Partial Female-to-Male Sex Reversal in the Silkworm, Bombyx mori. Sakai H, et al. PLoS Genet, 2016 Aug. PMID 27579676, Free PMC Article
    2. The mechanism of sex-specific splicing at the doublesex gene is different between Drosophila melanogaster and Bombyx mori. Suzuki MG, et al. Insect Biochem Mol Biol, 2001 Nov 1. PMID 11583933
    3. Novel female-specific splice form of dsx in the silkworm, Bombyx mori. Shukla JN, et al. Genetica, 2011 Jan. PMID 20714790
    4. Novel female-specific trans-spliced and alternative splice forms of dsx in the silkworm Bombyx mori. Duan J, et al. Biochem Biophys Res Commun, 2013 Feb 15. PMID 23261436
    5. New insights into the genomic organization and splicing of the doublesex gene, a terminal regulator of sexual differentiation in the silkworm Bombyx mori. Duan J, et al. PLoS One, 2013. PMID 24244545, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fatty Acid Desaturase Bmdesat5, Suppressed in the Salivary Glands by Domestication, is Involved in Regulation of Food Intake in Silkworms.
      Title: Fatty Acid Desaturase Bmdesat5, Suppressed in the Salivary Glands by Domestication, is Involved in Regulation of Food Intake in Silkworms.
    2. Role of small nucleolar RNAs in alternative splicing of the doublesex gene in the silkworm, Bombyx mori.
      Title: Role of small nucleolar RNAs in alternative splicing of the doublesex gene in the silkworm, Bombyx mori.
    3. Transgenic and knockout analyses of Masculinizer and doublesex illuminated the unique functions of doublesex in germ cell sexual development of the silkworm, Bombyx mori.
      Title: Transgenic and knockout analyses of Masculinizer and doublesex illuminated the unique functions of doublesex in germ cell sexual development of the silkworm, Bombyx mori.
    4. Identification and characterization of sexually dimorphic neurons that express the sex-determining gene doublesex in the brain of silkmoth Bombyx mori.
      Title: Identification and characterization of sexually dimorphic neurons that express the sex-determining gene doublesex in the brain of silkmoth Bombyx mori.
    5. Results suggest that the antisense lncRNA Bmdsx-AS1 was involved in alternative splicing of Bmdsx in the silkworm.
      Title: An antisense lncRNA functions in alternative splicing of Bmdsx in the silkworm, Bombyx mori.
    6. knockdown of EPPase and one isoform of EcR (EcR-A) resulted in decreased expression of Bombyx doublesex (Bmdsx), a master regulatory gene for sexual differentiation of the silkworm in both male and female embryos.
      Title: Involvement of Ecdysone Signaling in the Expression of the doublesex Gene during Embryonic Development in the Silkworm, Bombyx mori.
    7. A new regulatory mechanism of doublesex alternative splicing in the silkworm.
      Title: Alternative splicing regulation of doublesex gene by RNA-binding proteins in the silkworm Bombyx mori.
    8. C-terminus of DSX(F5) splice form functioned as a regulatory domain during regulation of downstream target gene expression and the sexual development of somatic cells .
      Title: The C-terminus of DSX(F5) protein acts as a novel regulatory domain in Bombyx mori.
    9. Disruptions of dsx gene function produced either male-specific sexually-dimorphic defects or intersexual phenotypes; these results differ from those observed in other insects, including Drosophila melanogaster.
      Title: Sexually dimorphic traits in the silkworm, Bombyx mori, are regulated by doublesex.
    10. One of the Masc-R strains weakly expressed Masc-R in various tissues. Females heterozygous for the transgene expressed male-specific isoform of the Bombyx homolog of insulin-like growth factor II mRNA-binding protein (ImpM) and Bmdsx
      Title: Transgenic Expression of the piRNA-Resistant Masculinizer Gene Induces Female-Specific Lethality and Partial Female-to-Male Sex Reversal in the Silkworm, Bombyx mori.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    doublesex; transcription factor doublesex
    Names
    doublesex 5
    doublesex F1
    doublesex F2
    doublesex F3
    doublesex F5
    doublesex M1
    doublesex M3
    nonfunctional doublesex 2
    nonfunctional doublesex F4
    nonfunctional doublesex M2
    nonfunctional doublesex M4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043406.1 → NP_001036871.1  transcription factor doublesex isoform F

      See identical proteins and their annotated locations for NP_001036871.1

      Status: PROVISIONAL

      Source sequence(s)
      AB048543
      UniProtKB/TrEMBL
      Q9GV03, S5U9X4
      Conserved Domains (2) summary
      pfam00751
      Location:32 → 77
      DM; DM DNA binding domain
      pfam08828
      Location:171 → 230
      DSX_dimer; Doublesex dimerization domain

    2. NM_001111345.1 → NP_001104815.1  transcription factor doublesex isoform M

      See identical proteins and their annotated locations for NP_001104815.1

      Status: PROVISIONAL

      Source sequence(s)
      AB048544
      UniProtKB/TrEMBL
      Q9GR94, Q9GV02
      Conserved Domains (2) summary
      pfam00751
      Location:32 → 77
      DM; DM DNA binding domain
      pfam08828
      Location:171 → 227
      DSX_dimer; Doublesex dimerization domain

    RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM3026992v2 Primary Assembly

    Genomic

    1. NC_085131.1 Reference ASM3026992v2 Primary Assembly

      Range
      10593002..10796765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_062675972.1 → XP_062531956.1  doublesex isoform X4

      UniProtKB/TrEMBL
      S5U9Y1

    2. XM_012688769.4 → XP_012544223.1  doublesex isoform X6

      See identical proteins and their annotated locations for XP_012544223.1

      UniProtKB/TrEMBL
      Q9GR95, S5U9X4
      Conserved Domains (2) summary
      pfam00751
      Location:32 → 77
      DM; DM DNA binding domain
      pfam08828
      Location:171 → 230
      DSX_dimer; Doublesex dimerization domain

    3. XM_012688778.4 → XP_012544232.1  doublesex isoform X7

      See identical proteins and their annotated locations for XP_012544232.1

      UniProtKB/TrEMBL
      S5TJ21, S5U9X4
      Conserved Domains (2) summary
      pfam00751
      Location:32 → 77
      DM; DM DNA binding domain
      pfam08828
      Location:171 → 230
      DSX_dimer; Doublesex dimerization domain

    4. XM_012688749.4 → XP_012544203.1  doublesex isoform X1

      See identical proteins and their annotated locations for XP_012544203.1

      UniProtKB/TrEMBL
      S5TSF6, S5U957
      Conserved Domains (2) summary
      pfam00751
      Location:32 → 77
      DM; DM DNA binding domain
      pfam08828
      Location:198 → 254
      DSX_dimer; Doublesex dimerization domain

    5. XM_038020188.2 → XP_037876116.1  doublesex isoform X2

      UniProtKB/TrEMBL
      A0A8R2M6Y2
      Conserved Domains (2) summary
      pfam08828
      Location:199 → 257
      DSX_dimer; Doublesex dimerization domain
      pfam00751
      Location:32 → 77
      DM; DM DNA binding domain

    6. XM_062675970.1 → XP_062531954.1  doublesex isoform X2

      UniProtKB/TrEMBL
      A0A8R2M6Y2

    7. XM_012688790.4 → XP_012544244.1  doublesex isoform X9

      See identical proteins and their annotated locations for XP_012544244.1

      UniProtKB/TrEMBL
      S5TJ17, S5U9X4
      Conserved Domains (2) summary
      pfam00751
      Location:32 → 77
      DM; DM DNA binding domain
      pfam08828
      Location:171 → 230
      DSX_dimer; Doublesex dimerization domain

    8. XM_012688757.4 → XP_012544211.1  doublesex isoform X5

      See identical proteins and their annotated locations for XP_012544211.1

      UniProtKB/TrEMBL
      S5TSE9, S5U9X4
      Conserved Domains (2) summary
      pfam00751
      Location:32 → 77
      DM; DM DNA binding domain
      pfam08828
      Location:198 → 257
      DSX_dimer; Doublesex dimerization domain

    9. XM_062675971.1 → XP_062531955.1  doublesex isoform X3

    10. XM_062675974.1 → XP_062531958.1  doublesex isoform X8

    11. XM_062675973.1 → XP_062531957.1  doublesex isoform X8

    Nucleotide Protein
    Heading Accession and Version

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