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    C2cd5 C2 calcium-dependent domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362461, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C2cd5provided by RGD
    Official Full Name
    C2 calcium-dependent domain containing 5provided by RGD
    Primary source
    RGD:1304592
    See related
    EnsemblRapid:ENSRNOG00000014382 AllianceGenome:RGD:1304592
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304592
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; positive regulation of protein targeting to membrane; and positive regulation of transport. Predicted to act upstream of or within positive regulation of D-glucose import and vesicle fusion. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic vesicle membrane; and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human C2CD5 (C2 calcium dependent domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 106.0), Thymus (RPKM 98.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C2cd5 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177700515..177790576, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175969544..176055597, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (177245868..177331910, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Neighboring gene uncharacterized LOC134486862 Neighboring gene ethanolamine kinase 1 Neighboring gene uncharacterized LOC134486689

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Xie X, et al. Cell Metab, 2011 Sep 7. PMID 21907143, Free PMC Article
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of D-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C2 domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134581.1 → NP_001128053.1  C2 domain-containing protein 5

      See identical proteins and their annotated locations for NP_001128053.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A0A0G2K543, A6IMW8
      Related
      ENSRNOP00000059174.3, ENSRNOT00000065387.4
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      177700515..177790576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237639.5 → XP_006237701.1  C2 domain-containing protein 5 isoform X36

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    2. XM_006237638.5 → XP_006237700.1  C2 domain-containing protein 5 isoform X31

      UniProtKB/TrEMBL
      A0A0G2K543, A0A8I5ZNZ8
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    3. XM_006237636.5 → XP_006237698.1  C2 domain-containing protein 5 isoform X24

      UniProtKB/TrEMBL
      A0A0G2K543, D4A5B3
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    4. XM_063286381.1 → XP_063142451.1  C2 domain-containing protein 5 isoform X21

    5. XM_063286379.1 → XP_063142449.1  C2 domain-containing protein 5 isoform X20

      Related
      ENSRNOP00000104219.1, ENSRNOT00000155885.1

    6. XM_039107923.2 → XP_038963851.1  C2 domain-containing protein 5 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K543
      Related
      ENSRNOP00000105208.1, ENSRNOT00000122861.1
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    7. XM_017592715.3 → XP_017448204.1  C2 domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K543

    8. XM_006237640.5 → XP_006237702.1  C2 domain-containing protein 5 isoform X37

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    9. XM_039107934.2 → XP_038963862.1  C2 domain-containing protein 5 isoform X28

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    10. XM_006237637.5 → XP_006237699.1  C2 domain-containing protein 5 isoform X25

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    11. XM_039107937.2 → XP_038963865.1  C2 domain-containing protein 5 isoform X33

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    12. XM_039107933.2 → XP_038963861.1  C2 domain-containing protein 5 isoform X27

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    13. XM_006237634.5 → XP_006237696.1  C2 domain-containing protein 5 isoform X19

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    14. XM_063286383.1 → XP_063142453.1  C2 domain-containing protein 5 isoform X35

      UniProtKB/TrEMBL
      A0A8I6AAM3

    15. XM_039107936.2 → XP_038963864.1  C2 domain-containing protein 5 isoform X30

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    16. XM_017592723.3 → XP_017448212.1  C2 domain-containing protein 5 isoform X23

      UniProtKB/TrEMBL
      A0A0G2K543, A0A8I6GFP7

    17. XM_039107932.2 → XP_038963860.1  C2 domain-containing protein 5 isoform X26

      UniProtKB/TrEMBL
      A0A0G2K543
      Related
      ENSRNOP00000088901.2, ENSRNOT00000114647.2
      Conserved Domains (1) summary
      cd08688
      Location:5 → 114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    18. XM_017592722.3 → XP_017448211.1  C2 domain-containing protein 5 isoform X15

      UniProtKB/TrEMBL
      A0A0G2K543
      Related
      ENSRNOP00000087996.2, ENSRNOT00000111414.2

    19. XM_039107938.2 → XP_038963866.1  C2 domain-containing protein 5 isoform X34

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    20. XM_039107935.2 → XP_038963863.1  C2 domain-containing protein 5 isoform X29

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    21. XM_039107929.2 → XP_038963857.1  C2 domain-containing protein 5 isoform X22

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    22. XM_039107927.2 → XP_038963855.1  C2 domain-containing protein 5 isoform X14

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    23. XM_063286378.1 → XP_063142448.1  C2 domain-containing protein 5 isoform X18

    24. XM_039107925.2 → XP_038963853.1  C2 domain-containing protein 5 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    25. XM_063286377.1 → XP_063142447.1  C2 domain-containing protein 5 isoform X17

    26. XM_039107921.2 → XP_038963849.1  C2 domain-containing protein 5 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    27. XM_039107918.2 → XP_038963846.1  C2 domain-containing protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    28. XM_063286376.1 → XP_063142446.1  C2 domain-containing protein 5 isoform X13

    29. XM_063286375.1 → XP_063142445.1  C2 domain-containing protein 5 isoform X10

    30. XM_039107920.2 → XP_038963848.1  C2 domain-containing protein 5 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    31. XM_039107924.2 → XP_038963852.1  C2 domain-containing protein 5 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    32. XM_039107919.2 → XP_038963847.1  C2 domain-containing protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    33. XM_039107922.2 → XP_038963850.1  C2 domain-containing protein 5 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    34. XM_039107916.2 → XP_038963844.1  C2 domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    35. XM_063286382.1 → XP_063142452.1  C2 domain-containing protein 5 isoform X32

    36. XM_039107928.2 → XP_038963856.1  C2 domain-containing protein 5 isoform X16

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    37. XM_039107926.2 → XP_038963854.1  C2 domain-containing protein 5 isoform X12

      UniProtKB/TrEMBL
      A0A0G2K543
      Conserved Domains (1) summary
      cd08688
      Location:5 → 118
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    38. XM_039107941.2 → XP_038963869.1  C2 domain-containing protein 5 isoform X40

    39. XM_039107940.2 → XP_038963868.1  C2 domain-containing protein 5 isoform X39

    40. XM_017592725.3 → XP_017448214.1  C2 domain-containing protein 5 isoform X38

    41. XM_039107942.2 → XP_038963870.1  C2 domain-containing protein 5 isoform X41

    42. XM_039107943.2 → XP_038963871.1  C2 domain-containing protein 5 isoform X42

    RNA

    1. XR_010065681.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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