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    cut9 anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541592, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cut9
    Official Full Name
    anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6
    Primary source
    PomBase:SPAC6F12.15c
    Locus tag
    SPOM_SPAC6F12.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    apc6; dre1
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    Genomic context

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    See cut9 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (1342057..1344785, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene geranyltranstransferase Fps1 Neighboring gene anaphase-promoting complex TPR lobe subcomplex subunit Apc8 Neighboring gene ncRNA Neighboring gene TRAMP complex ATP-dependent RNA helicase subunit Mtr4 Neighboring gene ncRNA Neighboring gene cleavage and polyadenylation specificity factor complex subunit Rna14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis. Tatebayashi K, et al. Genetics, 1998 Jan. PMID 9475720, Free PMC Article
    2. Cut2 proteolysis required for sister-chromatid seperation in fission yeast. Funabiki H, et al. Nature, 1996 May 30. PMID 8632802
    3. The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27. Zhang Z, et al. EMBO J, 2010 Nov 3. PMID 20924356, Free PMC Article
    4. The role of the destruction box and its neighbouring lysine residues in cyclin B for anaphase ubiquitin-dependent proteolysis in fission yeast: defining the D-box receptor. Yamano H, et al. EMBO J, 1998 Oct 1. PMID 9755167, Free PMC Article
    5. APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation. Blanco MA, et al. EMBO J, 2000 Aug 1. PMID 10921876, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1342057..1344785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018731.3 → NP_593301.1  anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593301.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14231, P41889
      Conserved Domains (5) summary
      sd00006
      Location:475 → 503
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:516 → 545
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:96 → 176
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13181
      Location:200 → 232
      TPR_8; Tetratricopeptide repeat
      pfam13414
      Location:516 → 581
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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