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    slc14a2 solute carrier family 14 member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 326634, updated on 2-Nov-2024

    Summary

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    Official Symbol
    slc14a2provided by ZNC
    Official Full Name
    solute carrier family 14 member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4833
    See related
    Ensembl:ENSDARG00000051914 AllianceGenome:ZFIN:ZDB-GENE-030131-4833
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    UT; fe01a06; wu:fe01a06; zgc:136632
    Summary
    Predicted to enable urea transmembrane transporter activity. Acts upstream of or within urea transport. Predicted to be located in plasma membrane. Is expressed in several structures, including EVL; digestive system; gill; muscle; and pronephros. Orthologous to several human genes including SLC14A1 (solute carrier family 14 member 1 (Kidd blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See slc14a2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (52168042..52177824)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (51521469..51531231)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-198e13.3 Neighboring gene uncharacterized LOC137495633 Neighboring gene SET binding protein 1 Neighboring gene leucyl/cystinyl aminopeptidase Neighboring gene endoplasmic reticulum aminopeptidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The responses of zebrafish (Danio rerio) to high external ammonia and urea transporter inhibition: nitrogen excretion and expression of rhesus glycoproteins and urea transporter proteins. Braun MH, et al. J Exp Biol, 2009 Dec. PMID 19915127
    2. Nitrogenous Waste Handling by Larval Zebrafish Danio rerio in Alkaline Water. Kumai Y, et al. Physiol Biochem Zool, 2015 Mar-Apr. PMID 25730269
    3. Nitrogen excretion in developing zebrafish (Danio rerio): a role for Rh proteins and urea transporters. Braun MH, et al. Am J Physiol Renal Physiol, 2009 May. PMID 19279128
    4. Role of the cardiovascular system in ammonia excretion in early life stages of zebrafish (Danio rerio). Wang Y, et al. Am J Physiol Regul Integr Comp Physiol, 2021 Sep 1. PMID 34318705
    5. The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos. Fu J, et al. Ecotoxicol Environ Saf, 2020 Feb. PMID 31830605

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of UT caused urea excretion to decrease by approximately 90%
      Title: Nitrogen excretion in developing zebrafish (Danio rerio): a role for Rh proteins and urea transporters.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables urea transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in urea transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within urea transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within urea transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    urea transporter 2
    Names
    solute carrier family 14 (urea transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020519.1 → NP_001018355.1  urea transporter 2

      See identical proteins and their annotated locations for NP_001018355.1

      Status: PROVISIONAL

      Source sequence(s)
      AY788989
      UniProtKB/TrEMBL
      A4FUM6, Q533H0
      Related
      ENSDARP00000135209.1, ENSDART00000162256.2
      Conserved Domains (1) summary
      pfam03253
      Location:98 → 392
      UT; Urea transporter

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      52168042..52177824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476011.2 → XP_021331686.1  urea transporter 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q878
      Conserved Domains (1) summary
      pfam03253
      Location:58 → 353
      UT; Urea transporter
    Nucleotide Protein Strain
    Heading Accession and Version

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