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    ndrg3b ndrg family member 3b [ Danio rerio (zebrafish) ]

    Gene ID: 327395, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ndrg3bprovided by ZNC
    Official Full Name
    ndrg family member 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5606
    See related
    Ensembl:ENSDARG00000010052 AllianceGenome:ZFIN:ZDB-GENE-030131-5606
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NDRG3; fi05h10; zgc:55301; wu:fi05h10
    Summary
    Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in immature eye; nervous system; otic vesicle; pectoral fin bud; and thymus. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndrg3b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (14832540..14990834, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (15076463..15234839, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene exosome component 10 Neighboring gene Src like adaptor 2b Neighboring gene PHD finger protein 20, b Neighboring gene Rho GTPase activating protein 46b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. Le N, et al. FASEB J, 2021 Nov. PMID 34665878, Free PMC Article
    2. N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. Park JS, et al. Elife, 2022 Oct 10. PMID 36214665, Free PMC Article
    3. A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination. Yan YL, et al. Genetics, 2019 Oct. PMID 31399485, Free PMC Article
    4. Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish. Li RA, et al. Blood, 2016 Dec 29. PMID 27827822
    5. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein NDRG3b
    Names
    N-myc downstream regulated 3
    N-myc downstream regulated family member 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199797.1 → NP_956091.1  protein NDRG3b

      See identical proteins and their annotated locations for NP_956091.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044139
      UniProtKB/TrEMBL
      Q803Y9
      Related
      ENSDARP00000007759.7, ENSDART00000010258.10
      Conserved Domains (2) summary
      COG0596
      Location:42 → 312
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      14832540..14990834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161986.3 → XP_005162043.1  protein NDRG3b isoform X5

      UniProtKB/TrEMBL
      A0A8M2B8X2, F1Q947
      Related
      ENSDARP00000148335.1, ENSDART00000179831.1
      Conserved Domains (2) summary
      COG0596
      Location:42 → 312
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    2. XM_009296689.2 → XP_009294964.1  protein NDRG3b isoform X2

      UniProtKB/TrEMBL
      A0A8M3ANG1
      Conserved Domains (2) summary
      COG0596
      Location:42 → 312
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    3. XM_017353522.2 → XP_017209011.1  protein NDRG3b isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z4D4

    4. XM_009296691.3 → XP_009294966.1  protein NDRG3b isoform X1

      UniProtKB/TrEMBL
      A0A8M3AV52
      Conserved Domains (2) summary
      COG0596
      Location:42 → 312
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:32 → 316
      Ndr; Ndr family

    5. XM_068216683.1 → XP_068072784.1  protein NDRG3b isoform X1

    6. XM_068216684.1 → XP_068072785.1  protein NDRG3b isoform X6

    7. XM_009296690.3 → XP_009294965.1  protein NDRG3b isoform X4

      UniProtKB/TrEMBL
      A0A8M3AY71
      Conserved Domains (2) summary
      COG0596
      Location:28 → 298
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:18 → 302
      Ndr; Ndr family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395136.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      296448..417152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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