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    ubap1 ubiquitin associated protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393183, updated on 12-Sep-2024

    Summary

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    Official Symbol
    ubap1provided by ZNC
    Official Full Name
    ubiquitin associated protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-950
    See related
    Ensembl:ENSDARG00000058746 AllianceGenome:ZFIN:ZDB-GENE-040426-950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    UBAP-1; zgc:56228
    Summary
    Predicted to enable ubiquitin binding activity. Acts upstream of or within axon extension. Predicted to be located in cytosol and endosome. Predicted to be part of ESCRT I complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia. Orthologous to human UBAP1 (ubiquitin associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See ubap1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (11865957..11881908)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11773329..11789280)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2R 2 Neighboring gene uncharacterized LOC137488785 Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene ubiquitin associated protein 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Stop-gain mutations in UBAP1 cause pure autosomal-dominant spastic paraplegia. Lin X, et al. Brain, 2019 Aug 1. PMID 31203368
    2. Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. Seiler C, et al. PLoS One, 2015. PMID 26161877, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56228

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328344.1 → NP_001315273.1  ubiquitin-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      CU694487, EH488960
      UniProtKB/Swiss-Prot
      F6P6X0, Q7ZV44
      Related
      ENSDARP00000076116.5, ENSDART00000081676.6
      Conserved Domains (5) summary
      PHA03247
      Location:120 → 332
      PHA03247; large tegument protein UL36; Provisional
      cd14315
      Location:339 → 381
      UBA1_UBAP1; UBA1 domain found in vertebrate ubiquitin-associated protein 1 (UBAP-1)
      cd14316
      Location:411 → 447
      UBA2_UBAP1_like; UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins
      TIGR00601
      Location:273 → 380
      rad23; UV excision repair protein Rad23
      pfam10240
      Location:12 → 61
      DUF2464; Multivesicular body subunit 12

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      11865957..11881908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200214.1: Suppressed sequence

      Description
      NM_200214.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F6P6X0.1 GenPept UniProtKB/Swiss-Prot:F6P6X0

    Gene LinkOut

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