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    mc2r melanocortin 2 receptor [ Danio rerio (zebrafish) ]

    Gene ID: 353152, updated on 28-Oct-2024

    Summary

    Official Symbol
    mc2rprovided by ZNC
    Official Full Name
    melanocortin 2 receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030502-2
    See related
    Ensembl:ENSDARG00000054949 AllianceGenome:ZFIN:ZDB-GENE-030502-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Enables corticotropin receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; adrenal gland development; and multicellular organismal response to stress. Located in cytoplasm and plasma membrane. Is expressed in adipose tissue; integument; pleuroperitoneal region; and steroid hormone secreting cell. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See mc2r in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30576087..30577001)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30615870..30619133)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene lamin A Neighboring gene melanocortin 5b receptor Neighboring gene family with sequence similarity 210 member Ab

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables corticotropin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables melanocortin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adrenocorticotropic hormone receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180971.1NP_851302.1  adrenocorticotropic hormone receptor

      See identical proteins and their annotated locations for NP_851302.1

      Status: PROVISIONAL

      Source sequence(s)
      AY161848
      UniProtKB/TrEMBL
      Q7ZTA2
      Related
      ENSDARP00000071699.2, ENSDART00000077231.3
      Conserved Domains (2) summary
      pfam00001
      Location:35276
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:36172
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      30576087..30577001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)