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    tra2b transformer 2 beta homolog [ Danio rerio (zebrafish) ]

    Gene ID: 394172, updated on 28-Oct-2024

    Summary

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    Official Symbol
    tra2bprovided by ZNC
    Official Full Name
    transformer 2 beta homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1094
    See related
    Ensembl:ENSDARG00000002168 AllianceGenome:ZFIN:ZDB-GENE-040426-1094
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sfrs10; zgc:56612
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in brain. Orthologous to human TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tra2b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (12579077..12594751, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (12607874..12623574, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 41aa Neighboring gene insulin-like growth factor 2 mRNA binding protein 2a Neighboring gene thrombospondin-type laminin G domain and EAR repeats b Neighboring gene small ubiquitin like modifier 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts. Moussavi Nik SH, et al. BMC Res Notes, 2014 Oct 31. PMID 25359609, Free PMC Article
    2. Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS. Bourefis AR, et al. Neurobiol Dis, 2020 Aug. PMID 32380281
    3. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Zhang Y, et al. Cell Rep, 2017 Jan 10. PMID 28076796, Free PMC Article
    4. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56612

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transformer-2 protein homolog beta
    Names
    splicing factor, arginine/serine-rich, 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201197.1 → NP_957491.1  transformer-2 protein homolog beta

      See identical proteins and their annotated locations for NP_957491.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049051
      UniProtKB/TrEMBL
      Q7ZUG9
      Related
      ENSDARP00000016139.6, ENSDART00000021266.7
      Conserved Domains (2) summary
      COG0724
      Location:118 → 199
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12641
      Location:114 → 202
      RRM_TRA2B; RNA recognition motif in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      12579077..12594751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167474.5 → XP_005167531.1  transformer-2 protein homolog beta isoform X1

      See identical proteins and their annotated locations for XP_005167531.1

      UniProtKB/TrEMBL
      A0A8M2BEY8
      Conserved Domains (2) summary
      COG0724
      Location:13 → 94
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12641
      Location:9 → 97
      RRM_TRA2B; RNA recognition motif in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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