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    MRPL25 mitochondrial 54S ribosomal protein YmL25 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852967, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MRPL25
    Official Full Name
    mitochondrial 54S ribosomal protein YmL25
    Primary source
    SGD:S000003308
    Locus tag
    YGR076C
    See related
    AllianceGenome:SGD:S000003308; FungiDB:YGR076C; VEuPathDB:YGR076C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AFO1; mL59; YMR26
    Summary
    A structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MRPL25 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (637104..637577, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Upf3p Neighboring gene mRNA splicing protein SMD1 Neighboring gene U4/U6-U5 snRNP complex subunit PRP38 Neighboring gene Pex8p Neighboring gene tubulin-binding prefolding complex subunit PAC10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and analysis of YMR26, the nuclear gene for a mitochondrial ribosomal protein in Saccharomyces cerevisiae. Kang W, et al. Mol Gen Genet, 1991 Mar. PMID 2017142
    2. Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory Deficient afo1(-) Yeast Suppressed by a Dominant Mutation in ATP3. Li J, et al. G3 (Bethesda), 2020 Dec 3. PMID 33093184, Free PMC Article
    3. Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. Rinnerthaler M, et al. Proc Natl Acad Sci U S A, 2012 May 29. PMID 22586098, Free PMC Article
    4. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Heeren G, et al. Aging (Albany NY), 2009 Jul 13. PMID 20157544, Free PMC Article
    5. Truncation of the Mrp20 protein reveals new ribosome-assembly subcomplex in mitochondria. Kaur J, et al. EMBO Rep, 2011 Sep 1. PMID 21779004, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AFO1/MRPL25 function establishes a new connection between mitochondria, metabolism and aging.
      Title: The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial 54S ribosomal protein YmL25
    NP_011590.1
    • Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      637104..637577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181205.1 → NP_011590.1  TPA: mitochondrial 54S ribosomal protein YmL25 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011590.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUK8, P23369
      UniProtKB/TrEMBL
      A6ZV58, B3LIF0, C7GXQ5, C8Z8X0, G2WEG0, N1P5S8
      Conserved Domains (1) summary
      pfam18126
      Location:13 → 138
      Mitoc_mL59; Mitochondrial ribosomal protein mL59
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23369.2

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