kif4 kinesin family member 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif4provided by ZNC
Official Full Name: kinesin family member 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1545
See related: Ensembl:ENSDARG00000005462 AllianceGenome:ZFIN:ZDB-GENE-040426-1545
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66125
Summary: Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in mitotic spindle organization. Predicted to act upstream of or within microtubule-based movement. Predicted to be located in microtubule. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to human KIF4A (kinesin family member 4A) and KIF4B (kinesin family member 4B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (44737594..44772729, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (44713348..44748483, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200823.1 → NP_957117.1 kinesin family member 4

See identical proteins and their annotated locations for NP_957117.1

Status: PROVISIONAL

Source sequence(s)

BC060673

UniProtKB/TrEMBL

Q6P9P4

Related

ENSDARP00000012856.7, ENSDART00000026178.8

Conserved Domains (5) summary

smart00129
Location:10 → 345

KISc; Kinesin motor, catalytic domain. ATPase

cd01372
Location:9 → 339

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam03638
Location:1100 → 1136

TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

pfam11917
Location:938 → 1082

DUF3435; Protein of unknown function (DUF3435)

pfam16716
Location:568 → 644

BST2; Bone marrow stromal antigen 2