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    erlec1 endoplasmic reticulum lectin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 368331, updated on 28-Oct-2024

    Summary

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    Official Symbol
    erlec1provided by ZNC
    Official Full Name
    endoplasmic reticulum lectin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030521-15
    See related
    Ensembl:ENSDARG00000086309 AllianceGenome:ZFIN:ZDB-GENE-030521-15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb309; zgc:55819; wu:fi15g10
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to be involved in retrograde protein transport, ER to cytosol. Predicted to act upstream of or within ERAD pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Is expressed in several structures, including anterior axial hypoblast; axial mesoderm; axis; hatching gland; and otic placode. Orthologous to human ERLEC1 (endoplasmic reticulum lectin 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See erlec1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (35750708..35760917, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (35624876..35635085, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 4a Neighboring gene G protein-coupled receptor 75 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene potassium channel, subfamily K, member 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish. Fung C, et al. Int J Mol Sci, 2023 Jan 27. PMID 36768797, Free PMC Article
    2. Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians. Maugars G, et al. PLoS One, 2015. PMID 26271038, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum lectin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199432.1 → NP_955464.1  endoplasmic reticulum lectin 1 precursor

      See identical proteins and their annotated locations for NP_955464.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044498
      UniProtKB/TrEMBL
      Q803G0
      Related
      ENSDARP00000105173.2, ENSDART00000127476.3
      Conserved Domains (2) summary
      pfam07915
      Location:341 → 420
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:413 → 466
      PRKCSH; Glucosidase II beta subunit-like protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      35750708..35760917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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