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    rars1 arginyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 337070, updated on 28-Oct-2024

    Summary

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    Official Symbol
    rars1provided by ZNC
    Official Full Name
    arginyl-tRNA synthetase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9014
    See related
    Ensembl:ENSDARG00000054530 AllianceGenome:ZFIN:ZDB-GENE-030131-9014
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rars; zgc:56050; zgc:86730; wu:fa96g09
    Summary
    Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in cytoplasm. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin bud; and swim bladder. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rars1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (35327374..35378321)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (35292884..35343831)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-23e4.3 Neighboring gene interleukin 12B, b Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene uncharacterized LOC137488839 Neighboring gene sarcoglycan, delta (dystrophin-associated glycoprotein)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Giong HK, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872004
    2. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. Waldron AL, et al. PLoS One, 2017. PMID 28934368, Free PMC Article
    3. Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish. Lin SJ, et al. Genet Med, 2021 Oct. PMID 34172899, Free PMC Article
    4. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC86730

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within arginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arginine--tRNA ligase, cytoplasmic
    NP_956342.1
    XP_017208243.1
    XP_068071909.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200048.1 → NP_956342.1  arginine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_956342.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045884
      UniProtKB/TrEMBL
      Q7ZVF4
      Related
      ENSDARP00000107383.2, ENSDART00000130626.4
      Conserved Domains (5) summary
      cd00671
      Location:194 → 458
      ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
      smart01016
      Location:79 → 167
      Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
      PLN02286
      Location:79 → 661
      PLN02286; arginine-tRNA ligase
      cl12020
      Location:497 → 661
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
      cl19252
      Location:5 → 58
      MreC; rod shape-determining protein MreC

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      35327374..35378321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215808.1 → XP_068071909.1  arginine--tRNA ligase, cytoplasmic isoform X1

    2. XM_017352754.3 → XP_017208243.1  arginine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z3L7

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395096.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      307711..339966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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