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    ptpn11b protein tyrosine phosphatase non-receptor type 11b [ Danio rerio (zebrafish) ]

    Gene ID: 393426, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ptpn11bprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 11bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1158
    See related
    Ensembl:ENSDARG00000012340 AllianceGenome:ZFIN:ZDB-GENE-040426-1158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63553
    Summary
    Enables phosphatase activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be located in cytoplasm. Is expressed in head. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ptpn11b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (23918421..23998914)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (23991870..24069461)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489184 Neighboring gene hairy-related 9 Neighboring gene agrin Neighboring gene uncharacterized LOC137489125 Neighboring gene ring finger protein 223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Distinct and overlapping functions of ptpn11 genes in Zebrafish development. Bonetti M, et al. PLoS One, 2014. PMID 24736444, Free PMC Article
    2. Shp2-Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration. Hale AJ, et al. Mol Cell Biol, 2018 Feb 15. PMID 29203641, Free PMC Article
    3. Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects. Solman M, et al. Elife, 2022 May 10. PMID 35535491, Free PMC Article
    4. Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources. Andersen JN, et al. Methods, 2005 Jan. PMID 15588990
    5. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63553

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 11b
    Names
    protein tyrosine phosphatase, non-receptor type 11, b
    protein-tyrosine phosphatase SHP-2b
    shp3 protein
    NP_956748.1
    XP_005162214.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200454.1 → NP_956748.1  tyrosine-protein phosphatase non-receptor type 11b

      See identical proteins and their annotated locations for NP_956748.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055139
      UniProtKB/TrEMBL
      Q7SY37
      Related
      ENSDARP00000046950.7, ENSDART00000046951.9
      Conserved Domains (4) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      smart00194
      Location:246 → 519
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:276 → 519
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      23918421..23998914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162157.5 → XP_005162214.1  tyrosine-protein phosphatase non-receptor type 11b isoform X1

      See identical proteins and their annotated locations for XP_005162214.1

      UniProtKB/TrEMBL
      S6CMQ2
      Conserved Domains (4) summary
      cd09931
      Location:109 → 216
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:3 → 101
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      smart00194
      Location:244 → 517
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:274 → 517
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395150.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      254224..315534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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