klhl18 kelch-like family member 18 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klhl18provided by ZNC
Official Full Name: kelch-like family member 18provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5785
See related: Ensembl:ENSDARG00000004306 AllianceGenome:ZFIN:ZDB-GENE-030131-5785
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55359; wu:fi18c08
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (32743807..32756448)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (32760589..32773230)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kelch-like protein 18

Names: kelch-like 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199830.1 → NP_956124.1 kelch-like protein 18

See identical proteins and their annotated locations for NP_956124.1

Status: PROVISIONAL

Source sequence(s)

BC045319

UniProtKB/TrEMBL

Q7ZW26

Related

ENSDARP00000025821.8, ENSDART00000022909.9

Conserved Domains (6) summary

smart00612
Location:339 → 385

Kelch; Kelch domain

PHA03098
Location:36 → 507

PHA03098; kelch-like protein; Provisional

sd00038
Location:328 → 371

Kelch; KELCH repeat [structural motif]

pfam00651
Location:30 → 134

BTB; BTB/POZ domain

pfam01344
Location:515 → 559

Kelch_1; Kelch motif

pfam07707
Location:142 → 244

BACK; BTB And C-terminal Kelch