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    ace2 angiotensin I converting enzyme 2 [ Danio rerio (zebrafish) ]

    Gene ID: 492331, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ace2provided by ZNC
    Official Full Name
    angiotensin I converting enzyme 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-6
    See related
    Ensembl:ENSDARG00000016918 AllianceGenome:ZFIN:ZDB-GENE-041114-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92514
    Summary
    Predicted to enable carboxypeptidase activity and metallopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in several cellular components, including apical plasma membrane; cilium; and extracellular region. Predicted to be active in extracellular space and plasma membrane. Is expressed in brain; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ace2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (29981678..29996360, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (29734494..29749183, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene pirin Neighboring gene zgc:113276 Neighboring gene si:ch73-226l13.2 Neighboring gene interleukin-1 family member A Neighboring gene Nance-Horan syndrome b (congenital cataracts and dental anomalies) Neighboring gene si:ch211-161f7.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus). Chou CF, et al. Gene, 2006 Aug 1. PMID 16781089, Free PMC Article
    2. Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish. Kraus A, et al. Brain Behav Immun, 2022 May. PMID 35307504, Free PMC Article
    3. Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health? Ventura Fernandes BH, et al. Sci Total Environ, 2022 Mar 20. PMID 34942250, Free PMC Article
    4. Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease. Keskus AG, et al. Genome, 2022 Feb. PMID 34606733
    5. Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system. Prokop JW, et al. Gen Comp Endocrinol, 2015 May 1. PMID 25260253, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease.
      Title: Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiotensin-converting enzyme 2
    Names
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
    NP_001007298.1
    XP_005169416.1
    XP_005169417.1
    XP_068080258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007297.1 → NP_001007298.1  angiotensin-converting enzyme 2 precursor

      See identical proteins and their annotated locations for NP_001007298.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085667
      UniProtKB/TrEMBL
      A0A8M1N359, Q5U380
      Conserved Domains (2) summary
      cd06461
      Location:27 → 598
      M2_ACE; Peptidase family M2 Angiotensin converting enzyme (ACE)
      pfam16959
      Location:630 → 783
      Collectrin; Renal amino acid transporter

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      29981678..29996360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169360.5 → XP_005169417.1  angiotensin-converting enzyme 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BGN5
      Conserved Domains (2) summary
      cd06461
      Location:27 → 598
      M2_ACE; Peptidase family M2 Angiotensin converting enzyme (ACE)
      pfam16959
      Location:619 → 770
      Collectrin; Renal amino acid transporter

    2. XM_005169359.5 → XP_005169416.1  angiotensin-converting enzyme 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGQ7, E7F9E5
      Related
      ENSDARP00000106752.2, ENSDART00000126110.4
      Conserved Domains (2) summary
      cd06461
      Location:27 → 598
      M2_ACE; Peptidase family M2 Angiotensin converting enzyme (ACE)
      pfam16959
      Location:630 → 781
      Collectrin; Renal amino acid transporter

    3. XM_068224157.1 → XP_068080258.1  angiotensin-converting enzyme 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version

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