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    uxs1 UDP-glucuronate decarboxylase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 192315, updated on 2-Nov-2024

    Summary

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    Official Symbol
    uxs1provided by ZNC
    Official Full Name
    UDP-glucuronate decarboxylase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-37
    See related
    Ensembl:ENSDARG00000056102 AllianceGenome:ZFIN:ZDB-GENE-020419-37
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj36b08; CHUNP6891; zgc:91980; wu:fj36b08
    Summary
    Enables UDP-glucuronate decarboxylase activity. Acts upstream of or within several processes, including cartilage development; extracellular matrix organization; and proteoglycan biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including cartilage element; head; mesenchyme; perichondrium; and yolk syncytial layer. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See uxs1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (6255933..6370693)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (6277948..6392708)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch73-390b10.2 Neighboring gene ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a Neighboring gene teleost multiple tissue opsin 2b Neighboring gene ECRG4 augurin precursor a Neighboring gene NCK adaptor protein 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. de Andrea CE, et al. J Pathol, 2011 Jun. PMID 21506131
    2. Cartilage ultrastructure in proteoglycan-deficient zebrafish mutants brings to light new candidate genes for human skeletal disorders. Wiweger MI, et al. J Pathol, 2011 Mar. PMID 21294126
    3. UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Eames BF, et al. Dev Biol, 2010 May 15. PMID 20226781, Free PMC Article
    4. On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. Holmborn K, et al. J Biol Chem, 2012 Sep 28. PMID 22869369, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucuronate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-D-xylose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronic acid decarboxylase 1
    Names
    UXS-1
    NP_775349.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173242.2 → NP_775349.2  UDP-glucuronic acid decarboxylase 1

      See identical proteins and their annotated locations for NP_775349.2

      Status: VALIDATED

      Source sequence(s)
      CU639407, CU855778, FP102050
      UniProtKB/Swiss-Prot
      Q6GMI9, Q8JHG1
      Related
      ENSDARP00000072986.5, ENSDART00000078525.6
      Conserved Domains (3) summary
      cd05230
      Location:87 → 389
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      COG0451
      Location:87 → 394
      WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
      pfam11803
      Location:2 → 76
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      6255933..6370693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GMI9.2 GenPept UniProtKB/Swiss-Prot:Q6GMI9

    Gene LinkOut

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