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    TGFB1 transforming growth factor beta 1 [ Homo sapiens (human) ]

    Gene ID: 7040, updated on 4-Jan-2025

    Summary

    Official Symbol
    TGFB1provided by HGNC
    Official Full Name
    transforming growth factor beta 1provided by HGNC
    Primary source
    HGNC:HGNC:11766
    See related
    Ensembl:ENSG00000105329 MIM:190180; AllianceGenome:HGNC:11766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
    Expression
    Broad expression in spleen (RPKM 38.0), bone marrow (RPKM 32.1) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TGFB1 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41330323..41353922, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44151181..44174790, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41836228..41859827, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene uncharacterized LOC105372401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41825837-41826574 Neighboring gene coiled-coil domain containing 97 Neighboring gene Sharpr-MPRA regulatory regions 2264 and 10656 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41828472-41828958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41829057-41829826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41830597-41831366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41831367-41832136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41833547-41834068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41860203-41860704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14679 Neighboring gene B9 domain containing 2 Neighboring gene transmembrane protein 91 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10665 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41885758-41885931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41889835-41890334 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41892254-41892432 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41903234-41903906 Neighboring gene exosome component 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication is restricted by TGFB1 and SMAD2 in Langerhans cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Recombinant HIV-1 Env (gp120) induces high levels of TGFB1 mRNA expression in CD34+ hematopoietic progenitor cells PubMed
    env HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells PubMed
    env Inactivated HIV or gp120 increases HCV replication and enhances HCV-regulated transforming growth factor (TGF)-beta1 expression PubMed
    env HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300 PubMed
    env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
    env HIV-1 gp120-mediated suppression of CD34+ cell growth is entirely due to an upregulation of endogenous TGF-beta 1 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 induces TGF-beta production in human PBMC PubMed
    env HIV-1 gp160 and serum-free macrophage supernatant (MSP) enhance synthesis of type IV collagen by mesangial cells; anti-TGF-beta antibodies attenuate this gp160/MSP-induced collagen synthesis PubMed
    Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta PubMed
    tat HIV-1 Tat protein permits the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production PubMed
    tat HIV-1 Tat binds to GLI2 and GLI2 binds to the human TGFB1 promoter, suggesting a potential mechanism for TGFB1 induction in HIV-1 infection PubMed
    tat HIV-1 Tat and TGF-beta secretion enhance parasite entry in human macrophages by upregulating surface expression of CD91/LRP-1 PubMed
    tat TGF-beta inhibits/down-modulates HIV-1 Tat-induced IL-8 production PubMed
    tat HIV-1 Tat upregulation of TGF-beta 1 is likely involved in the regulation of MCP-1 transcription by Tat and the interactions of Tat with Smad-3 and Smad-4, two transcription factors whose activities are induced by the TGF-beta 1 pathway PubMed
    tat HIV-1 Tat upregulates TGF-beta 1 expression in a manner involving IL-6, an effect mediated by Tat amino acids 1-48 and potentially associated with immunosuppression, nephropathy, hematopoietic suppression and glomerulosclerosis PubMed
    Vpr vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed
    Vpu vpu Antibodies against TGF-beta or a TGF-beta receptor inhibitor SB431452 reverse Vpu-mediated profibrogenic activation of LX2 cells, suggesting that TGF-beta mediates these effects PubMed
    vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed
    capsid gag Treatment of monocyte-derived dendritic cells with TGF-beta1 significantly enhances their ability to capture HIV-1 particles measured by p24 levels in cells PubMed
    gag Transforming growth factor-beta1 is involved in the enhanced expression of HIV-1 by nicotine, as measured by p24 antigen levels in culture supernatants PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables cytokine activity PubMed 
    enables deubiquitinase activator activity PubMed 
    enables enzyme binding PubMed 
    enables growth factor activity PubMed 
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein serine/threonine kinase activator activity PubMed 
    enables protein-containing complex binding  
    enables type I transforming growth factor beta receptor binding PubMed 
    enables type I transforming growth factor beta receptor binding PubMed 
    enables type II transforming growth factor beta receptor binding PubMed 
    enables type II transforming growth factor beta receptor binding PubMed 
    enables type II transforming growth factor beta receptor binding PubMed 
    enables type III transforming growth factor beta receptor binding PubMed 
    enables type III transforming growth factor beta receptor binding PubMed 
    Items 1 - 25 of 210
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process PubMed 
    involved_in Langerhans cell differentiation  
    involved_in Notch signaling pathway  
    involved_in T cell homeostasis  
    involved_in T cell proliferation  
    involved_in adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains  
    involved_in aortic valve morphogenesis PubMed 
    NOT involved_in apoptotic process PubMed 
    involved_in branch elongation involved in mammary gland duct branching  
    involved_in bronchiole development  
    involved_in canonical Wnt signaling pathway  
    involved_in cell morphogenesis  
    involved_in cell-cell junction organization PubMed 
    involved_in cellular response to acetaldehyde  
    involved_in cellular response to dexamethasone stimulus  
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to insulin-like growth factor stimulus  
    involved_in cellular response to ionizing radiation  
    involved_in cellular response to low-density lipoprotein particle stimulus PubMed 
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to virus  
    involved_in chondrocyte differentiation PubMed 
    involved_in columnar/cuboidal epithelial cell maturation  
    involved_in connective tissue replacement involved in inflammatory response wound healing PubMed 
    involved_in defense response to fungus  
    involved_in digestive tract development  
    involved_in embryonic liver development  
    involved_in endoderm development  
    involved_in epithelial cell proliferation  
    acts_upstream_of epithelial to mesenchymal transition PubMed 
    acts_upstream_of_or_within epithelial to mesenchymal transition PubMed 
    involved_in epithelial to mesenchymal transition PubMed 
    involved_in epithelial to mesenchymal transition PubMed 
    involved_in extracellular matrix assembly PubMed 
    involved_in extrinsic apoptotic signaling pathway PubMed 
    involved_in face morphogenesis  
    involved_in female pregnancy  
    involved_in frontal suture morphogenesis  
    involved_in gene expression  
    involved_in germ cell migration  
    involved_in heart development  
    involved_in heart valve morphogenesis  
    involved_in hematopoietic progenitor cell differentiation PubMed 
    involved_in hyaluronan catabolic process PubMed 
    involved_in inner ear development  
    involved_in intracellular calcium ion homeostasis  
    involved_in lens fiber cell differentiation  
    involved_in liver regeneration  
    involved_in lung alveolus development  
    involved_in lymph node development  
    involved_in macrophage derived foam cell differentiation PubMed 
    involved_in mammary gland branching involved in thelarche  
    involved_in membrane protein intracellular domain proteolysis PubMed 
    involved_in muscle cell cellular homeostasis  
    involved_in myelination  
    involved_in myofibroblast differentiation PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of T cell proliferation  
    involved_in negative regulation of biomineral tissue development PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration PubMed 
    involved_in negative regulation of cell cycle PubMed 
    involved_in negative regulation of cell differentiation PubMed 
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cell-cell adhesion mediated by cadherin PubMed 
    involved_in negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of extracellular matrix disassembly PubMed 
    involved_in negative regulation of fat cell differentiation PubMed 
    acts_upstream_of_or_within negative regulation of gene expression PubMed 
    involved_in negative regulation of gene expression PubMed 
    acts_upstream_of negative regulation of gene expression PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of gene expression  
    acts_upstream_of negative regulation of gene expression PubMed 
    involved_in negative regulation of hyaluronan biosynthetic process PubMed 
    involved_in negative regulation of interleukin-17 production  
    involved_in negative regulation of macrophage cytokine production PubMed 
    involved_in negative regulation of miRNA transcription PubMed 
    acts_upstream_of negative regulation of miRNA transcription PubMed 
    involved_in negative regulation of myoblast differentiation PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target PubMed 
    involved_in negative regulation of neuroblast proliferation  
    involved_in negative regulation of ossification  
    involved_in negative regulation of phagocytosis  
    involved_in negative regulation of protein localization to plasma membrane PubMed 
    involved_in negative regulation of release of sequestered calcium ion into cytosol  
    involved_in negative regulation of skeletal muscle tissue development PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in neural tube closure  
    involved_in neural tube development  
    involved_in neuron apoptotic process  
    involved_in odontoblast differentiation  
    involved_in odontogenesis of dentin-containing tooth  
    involved_in oligodendrocyte development  
    involved_in osteoclast differentiation  
    involved_in phosphate-containing compound metabolic process PubMed 
    involved_in phospholipid homeostasis  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration PubMed 
    involved_in positive regulation of branching involved in ureteric bud morphogenesis  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway PubMed 
    acts_upstream_of positive regulation of canonical Wnt signaling pathway PubMed 
    involved_in positive regulation of cardiac muscle cell differentiation PubMed 
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production PubMed 
    involved_in positive regulation of chemotaxis PubMed 
    involved_in positive regulation of collagen biosynthetic process PubMed 
    involved_in positive regulation of collagen biosynthetic process PubMed 
    involved_in positive regulation of collagen biosynthetic process PubMed 
    involved_in positive regulation of endothelial cell apoptotic process PubMed 
    acts_upstream_of positive regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of exit from mitosis  
    acts_upstream_of positive regulation of extracellular matrix assembly PubMed 
    involved_in positive regulation of extracellular matrix assembly PubMed 
    involved_in positive regulation of extracellular matrix assembly PubMed 
    involved_in positive regulation of fibroblast migration PubMed 
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    acts_upstream_of positive regulation of gene expression PubMed 
    involved_in positive regulation of inflammatory response PubMed 
    involved_in positive regulation of interleukin-17 production PubMed 
    acts_upstream_of positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of interleukin-6 production PubMed 
    acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes PubMed 
    involved_in positive regulation of mesenchymal stem cell proliferation PubMed 
    involved_in positive regulation of miRNA transcription PubMed 
    involved_in positive regulation of microglia differentiation  
    involved_in positive regulation of mononuclear cell migration  
    involved_in positive regulation of odontogenesis  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of primary miRNA processing PubMed 
    involved_in positive regulation of protein import into nucleus PubMed 
    involved_in positive regulation of protein localization to nucleus PubMed 
    involved_in positive regulation of protein metabolic process PubMed 
    involved_in positive regulation of protein secretion PubMed 
    involved_in positive regulation of protein-containing complex assembly PubMed 
    involved_in positive regulation of receptor signaling pathway via STAT PubMed 
    involved_in positive regulation of regulatory T cell differentiation  
    involved_in positive regulation of smooth muscle cell differentiation  
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of superoxide anion generation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of tumor necrosis factor production PubMed 
    involved_in positive regulation of vascular endothelial growth factor production PubMed 
    involved_in positive regulation of vascular permeability PubMed 
    involved_in positive regulation of vasculature development PubMed 
    involved_in protein export from nucleus PubMed 
    involved_in receptor catabolic process PubMed 
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of blood vessel remodeling PubMed 
    involved_in regulation of blood vessel remodeling PubMed 
    involved_in regulation of branching involved in mammary gland duct morphogenesis  
    involved_in regulation of cartilage development  
    involved_in regulation of cell migration PubMed 
    involved_in regulation of cell population proliferation  
    involved_in regulation of enamel mineralization  
    NOT involved_in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  
    involved_in regulation of interleukin-23 production  
    NOT involved_in regulation of miRNA transcription PubMed 
    involved_in regulation of protein import into nucleus  
    involved_in regulation of sodium ion transport  
    involved_in regulation of striated muscle tissue development  
    involved_in regulatory T cell differentiation PubMed 
    involved_in response to cholesterol PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to immobilization stress  
    involved_in response to laminar fluid shear stress  
    involved_in response to progesterone PubMed 
    involved_in response to salt  
    involved_in response to vitamin D  
    involved_in response to wounding PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in retina vasculature development in camera-type eye  
    involved_in salivary gland morphogenesis PubMed 
    acts_upstream_of sprouting angiogenesis PubMed 
    involved_in stem cell proliferation  
    involved_in surfactant homeostasis  
    involved_in tolerance induction to self antigen  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in ureteric bud development  
    involved_in vasculogenesis  
    involved_in ventricular cardiac muscle tissue morphogenesis  
    Items 1 - 25 of 210
    Component Evidence Code Pubs
    located_in Golgi lumen  
    located_in axon  
    located_in blood microparticle PubMed 
    located_in cell surface PubMed 
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytoplasm PubMed 
    located_in extracellular matrix  
    located_in extracellular region  
    is_active_in extracellular space  
    is_active_in extracellular space PubMed 
    located_in extracellular space PubMed 
    colocalizes_with microvillus PubMed 
    located_in neuronal cell body  
    located_in nucleus PubMed 
    located_in plasma membrane  
    located_in platelet alpha granule lumen  

    General protein information

    Preferred Names
    transforming growth factor beta-1 proprotein
    Names
    TGF-beta-1
    latency-associated peptide
    prepro-transforming growth factor beta-1
    transforming growth factor beta1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013364.1 RefSeqGene

      Range
      5005..28604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000660.7NP_000651.3  transforming growth factor beta-1 proprotein preproprotein

      See identical proteins and their annotated locations for NP_000651.3

      Status: REVIEWED

      Source sequence(s)
      AC011462, BC000125, BM692012, X02812
      Consensus CDS
      CCDS33031.1
      UniProtKB/Swiss-Prot
      A8K792, P01137, Q9UCG4
      UniProtKB/TrEMBL
      A0A499FJK2
      Related
      ENSP00000221930.4, ENST00000221930.6
      Conserved Domains (2) summary
      cd19384
      Location:292390
      TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
      pfam00688
      Location:30261
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41330323..41353922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527242.3XP_011525544.1  transforming growth factor beta-1 proprotein isoform X1

      See identical proteins and their annotated locations for XP_011525544.1

      Conserved Domains (2) summary
      cd19384
      Location:293391
      TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
      pfam00688
      Location:30262
      TGFb_propeptide; TGF-beta propeptide

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44151181..44174790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321897.1XP_054177872.1  transforming growth factor beta-1 proprotein isoform X1

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