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    ist1 IST1 factor associated with ESCRT-III [ Danio rerio (zebrafish) ]

    Gene ID: 321460, updated on 12-Sep-2024

    Summary

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    Official Symbol
    ist1provided by ZNC
    Official Full Name
    IST1 factor associated with ESCRT-IIIprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-179
    See related
    Ensembl:ENSDARG00000051888 AllianceGenome:ZFIN:ZDB-GENE-030131-179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb16b04; zgc:55671; wu:fb16b04; wu:fi89e07
    Summary
    Acts upstream of or within axon extension and endosome organization. Predicted to be located in nuclear envelope. Is expressed in female organism. Orthologous to human IST1 (IST1 factor associated with ESCRT-III). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See ist1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (56472562..56484798)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (56171151..56183387)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100536797 Neighboring gene solute carrier family 22 member 31 Neighboring gene polycystic kidney disease 1-like 3 Neighboring gene dihydroorotate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. Allison R, et al. J Cell Biol, 2013 Aug 5. PMID 23897888, Free PMC Article
    2. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IST1 homolog
    Names
    KIAA0174-like protein
    increased sodium tolerance 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328509.1 → NP_001315438.1  IST1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR382281, CR848662, EH443906
      UniProtKB/TrEMBL
      A0A8M1P500, F1R0S8
      Related
      ENSDARP00000116734.1, ENSDART00000135259.3
      Conserved Domains (1) summary
      pfam03398
      Location:13 → 176
      Ist1; Regulator of Vps4 activity in the MVB pathway

    2. NM_212585.2 → NP_997750.1  IST1 homolog isoform 1

      See identical proteins and their annotated locations for NP_997750.1

      Status: VALIDATED

      Source sequence(s)
      CR382281, CR848662, EH443906, EH504842
      UniProtKB/TrEMBL
      A0A8M1PH49, Q7ZVT1
      Related
      ENSDARP00000068086.5, ENSDART00000073596.7
      Conserved Domains (1) summary
      pfam03398
      Location:13 → 176
      Ist1; Regulator of Vps4 activity in the MVB pathway

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      56472562..56484798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477395.2 → XP_021333070.1  IST1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M1PH49, Q7ZVT1
      Conserved Domains (1) summary
      pfam03398
      Location:13 → 176
      Ist1; Regulator of Vps4 activity in the MVB pathway
    Nucleotide Protein Strain
    Heading Accession and Version

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